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Review Open Access

Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)

  • Authors:
    • Prakriti Sen
    • Pooja Ganguly
    • Niladri Ganguly
  • View Affiliations / Copyright

    Affiliations: Cancer Biology Laboratory, School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751024, India
    Copyright: © Sen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 11-22
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    Published online on: October 30, 2017
       https://doi.org/10.3892/ol.2017.7292
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Abstract

Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection. The early oncoproteins E6 and E7 are important in this cellular transformation process. Epigenetic mechanisms have long been known to result in decisive alterations in DNA, leading to alterations in DNA‑protein interactions, alterations in chromatin structure and compaction and significant alterations in gene expression. The enzymes responsible for these epigenetic modifications are DNA methyl transferases (DNMTs), histone acetylases and deacetylases. Epigenetics has an important role in cancer development by modifying the cellular micro environment. In this review, the authors discuss the role of HPV oncoproteins E6 and E7 in modulating the epigenetic mechanisms inside the host cell. The oncoproteins induce the expression of DNMTs which lead to aberrant DNA methylations and disruption of the normal epigenetic processes. The E7 oncoprotein may additionally directly bind and induce methyl transferase activity of the enzyme. These modulations lead to altered gene expression levels, particularly the genes involved in apoptosis, cell cycle and cell adhesion. In addition, the present review discusses how epigenetic mechanisms may be targeted for possible therapeutic interventions for HPV mediated cervical cancer.
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1 

Bhat S, Kabekkodu SP, Noronha A and Satyamoorthy K: Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer. Biochimie. 121:298–311. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Panatto D, Amicizia D, Bragazzi NL, Rizzitelli E, Tramalloni D, Valle I and Gasparini R: Chapter Eight-Human Papillomavirus Vaccine: State of the Art and Future Perspectives. Adv Protein Chemistry Structural Biol. 101:231–322. 2015. View Article : Google Scholar

3 

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Pharmaceuticals: A Review of human carcinogens. IARC monographs on the evaluation of carcinogenic risks to humans. 100A:(IARC Monographs). 1–401. 2012.

4 

D'Andrilli G: Advances in cervical cancer and ongoing clinical trialsGynecological Cancers. Giordano A and Macaluso M: Springer International Publishing; Cham: pp. 51–64. 2016

5 

Zhao S: Specific Type Epigenetic Changes in Cervical CancersCancer Epigenetics, Methods in Molecular Biology (Methods and Protocols). 1238. Verma M: Humana Press; New York, NY: pp. 733–749. 2015

6 

Langsfeld E and Laimins LA: Human papillomaviruses: Research priorities for the next decade. Trends Cancer. 2:234–240. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hu H, Shu M, He L, Yu X, Liu X, Lu Y, Chen Y, Miao X and Chen X: Epigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer. Br J Cancer. 116:658–668. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Sova P, Feng Q, Geiss G, Wood T, Strauss R, Rudolf V, Lieber A and Kiviat N: Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Cancer Epidemiol Biomarkers Prev. 15:114–123. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Schneider A, Terry MB, Mansukhani M and Murty VV: Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: Its relationship to clinical outcome. Mol Cancer. 2:242003. View Article : Google Scholar : PubMed/NCBI

10 

Feng Q, Balasubramanian A, Hawes SE, Toure P, Sow PS, Dem A, Dembele B, Critchlow CW, Xi L, Lu H, et al: Detection of hypermethylated genes in women with and without cervical neoplasia. J Natl Cancer Inst. 97:273–282. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Steenbergen RD, Kramer D, Braakhuis BJ, Stern PL, Verheijen RH, Meijer CJ and Snijders PJ: TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia. J Natl Cancer Inst. 96:294–305. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Lu Q, Ma D and Zhao S: DNA methylation changes in cervical cancers. Methods Mol Biol. 863:155–176. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Trang P, Weidhaas JB and Slack FJ: MicroRNAs and cancerThe Molecular Basis of Human Cancer. Coleman WB and Tsongalis GJ: 2nd. Springer; New York, New York, NY: pp. 277–286. 2017, View Article : Google Scholar

14 

Leung TW, Liu SS, Leung RC, Chu MM, Cheung AN and Ngan HY: HPV 16 E2 binding sites 1 and 2 become more methylated than E2 binding site 4 during cervical carcinogenesis. J Med Virol. 87:1022–1033. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Doeberitz MVK and Vinokurova S: Compounds and methods associated with differential methylation of human papilloma virus genomes in epithelial cells. US Patent 12/740,986. Filed October 31, 2008; issued September 29. 2015.

16 

Kan YY, Liou YL, Wang HJ, Chen CY, Sung LC, Chang CF and Liao CI: PAX1 methylation as a potential biomarker for cervical cancer screening. Int J Gynecol Cancer. 24:928–934. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Jha AK, Nikbakht M, Jain V, Sehgal A, Capalash N and Kaur J: Promoter hypermethylation of p73 and p53 genes in cervical cancer patients among north Indian population. Mol Biol Rep. 39:9145–9157. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, Delbecque K, Kridelka F, Fuks F, Ennaji MM and Delvenne P: Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis. PLoS One. 7:e427042012. View Article : Google Scholar : PubMed/NCBI

19 

Missaoui N, Hmissa S, Trabelsi A, Traoré C, Mokni M, Dante R and Frappart L: Promoter hypermethylation of CDH13, DAPK1 and TWIST1 genes in precancerous and cancerous lesions of the uterine cervix. Pathol Res Pract. 207:37–42. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Yang HJ: Aberrant DNA methylation in cervical carcinogenesis. Chin J Cancer. 32:42–48. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Liz J and Esteller M: lncRNAs and microRNAs with a role in cancer development. Biochim Biophys Acta. 1859:169–176. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wang JT, Ding L, Jiang SW, Hao J, Zhao WM, Zhou Q, Yang ZK and Zhang L: Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization. Curr Pharm Des. 20:1639–1646. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Berdasco M and Esteller M: Aberrant epigenetic landscape in cancer: How cellular identity goes awry. Dev Cell. 19:698–711. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Jackson R, Rosa BA, Lameiras S, Cuninghame S, Bernard J, Floriano WB, Lambert PF, Nicolas A and Zehbe I: Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology. BMC Genomics. 17:8512016. View Article : Google Scholar : PubMed/NCBI

25 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Wilting SM, van Boerdonk RA, Henken FE, Meijer CJ, Diosdado B, Meijer GA, le Sage C, Agami R, Snijders PJ and Steenbergen RD: Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer. 9:1672010. View Article : Google Scholar : PubMed/NCBI

28 

Botezatu A, Goia-Rusanu CD, Iancu IV, Huica I, Plesa A, Socolov D, Ungureanu C and Anton G: Quantitative analysis of the relationship between microRNA-124a, −34b and −203 gene methylation and cervical oncogenesis. Mol Med Rep. 4:121–128. 2011.PubMed/NCBI

29 

Yao T, Rao Q, Liu L, Zheng C, Xie Q, Liang J and Lin Z: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in cervical cancer. Virol J. 10:1752013. View Article : Google Scholar : PubMed/NCBI

30 

Wilting SM, Verlaat W, Jaspers A, Makazaji NA, Agami R, Meijer CJ, Snijders PJ and Steenbergen RD: Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics. 8:220–228. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Morgan MA and Shilatifard A: Chromatin signatures of cancer. Genes Dev. 29:238–249. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Khan SA, Reddy D and Gupta S: Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment? World J Biol Chem. 6:333–345. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Ghittoni R, Accardi R, Chiocca S and Tommasino M: The role of human papillomaviruses in carcinogenesis. Ecancermedicalscience. 9:5262015. View Article : Google Scholar : PubMed/NCBI

34 

Ruttkay-Nedecky B, Jimenez AM Jimenez, Nejdl L, Chudobova D, Gumulec J, Masarik M, Adam V and Kizek R: Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review). Int J Oncol. 43:1754–1762. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Mesri EA, Feitelson MA and Munger K: Human viral oncogenesis: A cancer hallmarks analysis. Cell Host Microbe. 15:266–282. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Chen AA, Gheit T, Franceschi S, Tommasino M and Clifford GM; IARC HPV Variant Study Group, : Human papillomavirus 18 genetic variation and cervical cancer risk worldwide. J Virol. 89:10680–10687. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Evans W, Filippova M, Aragon R, Filippov V, Reeves ME and Duerksen-Hughes P: Abstract 1828: Proteomic analysis of the effect of E6 star expression on cellular pathways in HPV positive SiHa and HPV negative C33A cervical carcinoma cells. Cancer Res. 75:1828. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Illiano E, Demurtas OC, Massa S, Di Bonito P, Consalvi V, Chiaraluce R, Zanotto C, De Giuli Morghen C, Radaelli A, Venuti A and Franconi R: Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: Implications for HPV-tumor diagnosis and therapy. J Transl Med. 14:2242016. View Article : Google Scholar : PubMed/NCBI

39 

Duensing S and Münger K: The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res. 62:7075–7082. 2002.PubMed/NCBI

40 

Munger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, Grace M and Huh K: Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 78:11451–11460. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Kruiswijk F, Labuschagne CF and Vousden KH: p53 in survival, death and metabolic health: A lifeguard with a licence to kill. Nat Rev Mol Cell Biol. 16:393–405. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Hengstermann A, Linares LK, Ciechanover A, Whitaker NJ and Scheffner M: Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc Natl Acad Sci USA. 98:pp. 1218–1223. 2001; View Article : Google Scholar : PubMed/NCBI

43 

Mantovani F and Banks L: The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene. 20:7874–7887. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Paek AL, Liu JC, Loewer A, Forrester WC and Lahav G: Cell-to-cell variation in p53 dynamics leads to fractional killing. Cell. 165:631–642. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Yim EK and Park JS: The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis. Cancer Res Treat. 37:319–324. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Ganguly N and Parihar SP: Human papilloma virus E6 and E7 oncoproteins as risk factors for tumorigenesis. J Biosci. 34:113–123. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Tommasino M: The human papillomavirus family and its role in carcinogenesis. Semin Cancer Biol. 26:13–21. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Yin FF, Wang N, Bi XN, Yu X, Xu XH, Wang YL, Zhao CQ, Luo B and Wang YK: Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer. Virol J. 13:602016. View Article : Google Scholar : PubMed/NCBI

49 

Dueñas-González A, Lizano M, Candelaria M, Cetina L, Arce C and Cervera E: Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer. 4:382005. View Article : Google Scholar : PubMed/NCBI

50 

Whiteside MA, Siegel EM and Unger ER: Human papillomavirus and molecular considerations for cancer risk. Cancer. 113 Suppl 10:S2981–S2994. 2008. View Article : Google Scholar

51 

Leonard SM, Wei W, Collins SI, Pereira M, Diyaf A, Constandinou-Williams C, Young LS, Roberts S and Woodman CB: Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women. Carcinogenesis. 33:1286–1293. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Jiang P and Yue Y: Human papillomavirus oncoproteins and apoptosis (Review). Exp Ther Med. 7:3–7. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Burgers WA, Blanchon L, Pradhan S, de Launoit Y, Kouzarides T and Fuks F: Viral oncoproteins target the DNA methyltransferases. Oncogene. 26:1650–1655. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Au Yeung CL, Tsang WP, Tsang TY, Co NN, Yau PL and Kwok TT: HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53. Oncol Rep. 24:1599–1604. 2010.PubMed/NCBI

55 

Richards KL, Zhang B, Baggerly KA, Colella S, Lang JC, Schuller DE and Krahe R: Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability. PLoS One. 4:e49412009. View Article : Google Scholar : PubMed/NCBI

56 

Lin RK, Wu CY, Chang JW, Juan LJ, Hsu HS, Chen CY, Lu YY, Tang YA, Yang YC, Yang PC and Wang YC: Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res. 70:5807–5817. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Cai Q, Lv L, Shao Q, Li X and Dian A: Human papillomavirus early proteins and apoptosis. Arch Gynecol Obstet. 287:541–548. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Banzai C, Nishino K, Quan J, Yoshihara K, Sekine M, Yahata T and Tanaka K: Gynecological Cancer Registry of Niigata: Promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A genes in cervical carcinoma. Int J Clin Oncol. 19:127–132. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Samuelsson J, Alonso S, Ruiz-Larroya T, Cheung TH, Wong YF and Perucho M: Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in gastrointestinal and gynecological cancer. Int J Oncol. 38:1575–1577. 2011.PubMed/NCBI

60 

Shuangshoti S, Hourpai N, Pumsuk U and Mutirangura A: Line-1 hypomethylation in multistage carcinogenesis of the uterine cervix. Asian Pac J Cancer Prev. 8:307–309. 2007.PubMed/NCBI

61 

Badal V, Chuang LS, Tan EH, Badal S, Villa LL, Wheeler CM, Li BF and Bernard HU: CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: Genomic hypomethylation correlates with carcinogenic progression. J Virol. 77:6227–6234. 2003. View Article : Google Scholar : PubMed/NCBI

62 

How Kit A, Nielsen HM and Tost J: DNA methylation based biomarkers: Practical considerations and applications. Biochimie. 94:2314–2337. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Mersakova S, Nachajova M, Szepe P, Kasajova PS and Halasova E: DNA methylation and detection of cervical cancer and precancerous lesions using molecular methods. Tumor Biol. 37:23–27. 2016. View Article : Google Scholar

64 

Steenbergen RD, Snijders PJ, Heideman DA and Meijer CJ: Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions. Nat Rev Cancer. 14:395–405. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Whittaker SR, Mallinger A, Workman P and Clarke PA: Inhibitors of cyclin-dependent kinases as cancer therapeutics. Pharmacol Ther. 173:83–105. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Sherr CJ and Bartek J: Cell cycle-targeted cancer therapies S phase: The DNA synthesis phase of the cell cycle. 1:Annual Review of Cancer Biology. 41–57. 2017. View Article : Google Scholar

67 

Huang LW, Pan HS, Lin YH, Seow KM, Chen HJ and Hwang JL: P16 methylation is an early event in cervical carcinogenesis. Int J Gynecol Cancer. 21:452–456. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Terra AP, Murta EF, Maluf PJ, Caballero OL, Brait M and Adad SJ: Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade III. Tumori. 93:572–579. 2007.PubMed/NCBI

69 

Aran D, Sabato S and Hellman A: DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes. Genome Biol. 14:R212013. View Article : Google Scholar : PubMed/NCBI

70 

Chen CL, Liu SS, Ip SM, Wong LC, Ng TY and Ngan HY: E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours. Eur J Cancer. 39:517–523. 2003. View Article : Google Scholar : PubMed/NCBI

71 

Jeong DH, Youm MY, Kim YN, Lee KB, Sung MS, Yoon HK and Kim KT: Promoter methylation of p16, DAPK, CDH1, and TIMP-3 genes in cervical cancer: Correlation with clinicopathologic characteristics. Int J Gynecol Cancer. 16:1234–1240. 2006. View Article : Google Scholar : PubMed/NCBI

72 

Shivapurkar N, Sherman ME, Stastny V, Echebiri C, Rader JS, Nayar R, Bonfiglio TA, Gazdar AF and Wang SS: Evaluation of candidate methylation markers to detect cervical neoplasia. Gynecol Oncol. 107:549–553. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Overmeer RM, Henken FE, Snijders PJ, Claassen-Kramer D, Berkhof J, Helmerhorst TJ, Heideman DA, Wilting SM, Murakami Y, Ito A, et al: Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol. 215:388–397. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Yadav SS, Prasad SB, Das M, Kumari S, Pandey LK, Singh S, Pradhan S and Narayan G: Epigenetic silencing of CXCR4 promotes loss of cell adhesion in cervical cancer. Biomed Res Int. 2014:5814032014. View Article : Google Scholar : PubMed/NCBI

75 

Narayan G, Xie D, Ishdorj G, Scotto L, Mansukhani M, Pothuri B, Wright JD, Kaufmann AM, Schneider A, Arias-Pulido H and Murty VV: Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-cisplatin combination therapy in cervical cancer. Genes Chromosomes Cancer. 55:177–189. 2016. View Article : Google Scholar : PubMed/NCBI

76 

Snellenberg S, Cillessen SA, Van Criekinge W, Bosch L, Meijer CJ, Snijders PJ and Steenbergen RD: Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers. Carcinogenesis. 35:2611–2618. 2014. View Article : Google Scholar : PubMed/NCBI

77 

Michie AM, McCaig AM, Nakagawa R and Vukovic M: Death-associated protein kinase (DAPK) and signal transduction: Regulation in cancer. FEBS J. 277:74–80. 2010. View Article : Google Scholar : PubMed/NCBI

78 

Kim JH, Choi YD, Lee JS, Lee JH, Nam JH and Choi C: Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens. Gynecol Oncol. 116:99–104. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Yang N, Nijhuis ER, Volders HH, Eijsink JJ, Lendvai A, Zhang B, Hollema H, Schuuring E, Wisman GB and van der Zee AG: Gene promoter methylation patterns throughout the process of cervical carcinogenesis. Cell Oncol. 32:131–143. 2010.PubMed/NCBI

80 

Jha AK, Nikbakht M, Parashar G, Shrivastava A, Capalash N and Kaur J: Reversal of hypermethylation and reactivation of the RARβ2 gene by natural compounds in cervical cancer cell lines. Folia Biol (Praha). 56:195–200. 2010.PubMed/NCBI

81 

Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J and Seed B: The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem. 279:29247–29254. 2004. View Article : Google Scholar : PubMed/NCBI

82 

Aoki K and Taketo MM: Adenomatous polyposis coli (APC): A multi-functional tumor suppressor gene. J Cell Sci. 120:3327–3335. 2007. View Article : Google Scholar : PubMed/NCBI

83 

Dong SM, Kim HS, Rha SH and Sidransky D: Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res. 7:1982–1986. 2001.PubMed/NCBI

84 

Song Y and Zhang C: Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression. Cancer Chemother Pharmacol. 63:605–613. 2009. View Article : Google Scholar : PubMed/NCBI

85 

Baer C, Claus R and Plass C: Genome-wide epigenetic regulation of miRNAs in cancer. Cancer Res. 73:473–477. 2013. View Article : Google Scholar : PubMed/NCBI

86 

Jiménez-Wences H, Peralta-Zaragoza O and Fernández-Tilapa G: Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep. 31:2467–2476. 2014. View Article : Google Scholar : PubMed/NCBI

87 

Iida M, Banno K, Yanokura M, Nakamura K, Adachi M, Nogami Y, Umene K, Masuda K, Kisu I, Iwata T, et al: Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review). Mol Clin Oncol. 2:647–655. 2014. View Article : Google Scholar : PubMed/NCBI

88 

Dakubo GD: Methylated DNA as cancer biomarkers in circulationCancer Biomarkers in Body Fluids. 1st. Springer International Publishing; Cham: pp. 103–123. 2016, View Article : Google Scholar

89 

Huang RL, Su PH, Liao YP, Wu TI, Hsu YT, Lin WY, Wang HC, Weng YC, Ou YC, Huang TH and Lai HC: Integrated Epigenomics analysis reveals a DNA methylation panel for endometrial cancer detection using cervical scrapings. Clin Cancer Res. 23:263–272. 2017. View Article : Google Scholar : PubMed/NCBI

90 

Kahn SL, Ronnett BM, Gravitt PE and Gustafson KS: Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests. Cancer. 114:57–64. 2008. View Article : Google Scholar : PubMed/NCBI

91 

Wisman GB, Nijhuis ER, Hoque MO, Reesink-Peters N, Koning AJ, Volders HH, Buikema HJ, Boezen HM, Hollema H, Schuuring E, et al: Assessment of gene promoter hypermethylation for detection of cervical neoplasia. Int J Cancer. 119:1908–1914. 2006. View Article : Google Scholar : PubMed/NCBI

92 

Feng Q, Hawes SE, Stern JE, Dem A, Sow PS, Dembele B, Toure P, Sova P, Laird PW and Kiviat NB: Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Cancer Epidemiol Biomarkers Prev. 16:1178–1184. 2007. View Article : Google Scholar : PubMed/NCBI

93 

Huang BH, Laban M, Leung CH, Lee L, Lee CK, Salto-Tellez M, Raju GC and Hooi SC: Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase. Cell Death Differ. 12:395–404. 2005. View Article : Google Scholar : PubMed/NCBI

94 

Danam RP, Howell SR, Brent TP and Harris LC: Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. Mol Cancer Ther. 4:61–69. 2005.PubMed/NCBI

95 

Lee J, Yoon YS and Chung JH: Epigenetic silencing of the WNT antagonist DICKKOPF-1 in cervical cancer cell lines. Gynecol Oncol. 109:270–274. 2008. View Article : Google Scholar : PubMed/NCBI

96 

Bodily JM, Mehta KP and Laimins LA: Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Res. 71:1187–1195. 2011. View Article : Google Scholar : PubMed/NCBI

97 

Lu TY, Kao CF, Lin CT, Huang DY, Chiu CY, Huang YS and Wu HC: DNA methylation and histone modification regulate silencing of OPG during tumor progression. J Cell Biochem. 108:315–325. 2009. View Article : Google Scholar : PubMed/NCBI

98 

Zhang Z, Joh K, Yatsuki H, Zhao W, Soejima H, Higashimoto K, Noguchi M, Yokoyama M, Iwasaka T and Mukai T: Retinoic acid receptor beta 2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells. Cancer Lett. 247:318–327. 2007. View Article : Google Scholar : PubMed/NCBI

99 

Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M and Kurdistani SK: Global histone modification patterns predict risk of prostate cancer recurrence. Nature. 435:1262–1266. 2005. View Article : Google Scholar : PubMed/NCBI

100 

Plesa A, Iancu IV, Botezatu A, Huica I, Stoian M and Anton G: The involvement of epigenetic mechanisms in HPV-induced cervical cancer. Human Papillomavirus – Research in a Global Perspective. Rajkumar R: 9InTech. 2016. View Article : Google Scholar

101 

Easwaran H, Tsai HC and Baylin SB: Cancer Epigenetics: Tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell. 54:716–727. 2014. View Article : Google Scholar : PubMed/NCBI

102 

de la Cruz-Hernández E, Pérez-Cárdenas E, Contreras-Paredes A, Cantú D, Mohar A, Lizano M and Dueñas-González A: The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study. Virol J. 4:182007. View Article : Google Scholar : PubMed/NCBI

103 

Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q, et al: Autophagy and chemotherapy resistance: A promising therapeutic target for cancer treatment. Cell Death Dis. 4:e8382013. View Article : Google Scholar : PubMed/NCBI

104 

Hassan M, Watari H, AbuAlmaaty A, Ohba Y and Sakuragi N: Apoptosis and molecular targeting therapy in cancer. Biomed Res Int. 2014:1508452014. View Article : Google Scholar : PubMed/NCBI

105 

Esteller M: Epigenetics in cancer. N Engl J Med. 358:1148–1159. 2008. View Article : Google Scholar : PubMed/NCBI

106 

Fang J, Zhang H and Jin S: Epigenetics and cervical cancer: From pathogenesis to therapy. Tumor Biol. 35:5083–5093. 2014. View Article : Google Scholar

107 

Coronel J, Cetina L, Pacheco I, Trejo-Becerril C, González-Fierro A, de la Cruz-Hernandez E, Perez-Cardenas E, Taja-Chayeb L, Arias-Bofill D, Candelaria M, et al: A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results. Med Oncol. 28 Suppl 1:S540–S546. 2011. View Article : Google Scholar : PubMed/NCBI

108 

Zambrano P, Segura-Pacheco B, Perez-Cardenas E, Cetina L, Revilla-Vazquez A, Taja-Chayeb L, Chavez-Blanco A, Angeles E, Cabrera G, Sandoval K, et al: A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. BMC Cancer. 5:442005. View Article : Google Scholar : PubMed/NCBI

109 

You JS, Kang JK, Lee EK, Lee JC, Lee SH, Jeon YJ, Koh DH, Ahn SH, Seo DW, Lee HY, et al: Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells. Oncogene. 27:1376–1386. 2008. View Article : Google Scholar : PubMed/NCBI

110 

Kelly WK, O'Connor OA, Krug LM, Chiao JH, Heaney M, Curley T, MacGregore-Cortelli B, Tong W, Secrist JP, Schwartz L, et al: Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J Clin Oncol. 23:3923–3931. 2005. View Article : Google Scholar : PubMed/NCBI

111 

Chen CC, Lee KD, Pai MY, Chu PY, Hsu CC, Chiu CC, Chen LT, Chang JY, Hsiao SH and Leu YW: Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells. Cancer Cell Int. 15:982015. View Article : Google Scholar : PubMed/NCBI

112 

Sato N, Maitra A, Fukushima N, van Heek NT, Matsubayashi H, Iacobuzio-Donahue CA, Rosty C and Goggins M: Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 63:4158–1166. 2003.PubMed/NCBI

113 

Virmani AK, Muller C, Rathi A, Zoechbauer-Mueller S, Mathis M and Gazdar AF: Aberrant methylation during cervical carcinogenesis. Clin Cancer Res. 7:584–589. 2001.PubMed/NCBI

114 

Kim YT and Zhao M: Aberrant cell cycle regulation in cervical carcinoma. Yonsei Med J. 46:597–613. 2005. View Article : Google Scholar : PubMed/NCBI

115 

Ohtani N, Yamakoshi K, Takahashi A and Hara E: The p16INK4a-RB pathway: Molecular link between cellular senescence and tumor suppression. J Med Invest. 51:146–153. 2004. View Article : Google Scholar : PubMed/NCBI

116 

Ki KD, Lee SK, Tong SY, Lee JM, Song DH and Chi SG: Role of 5′-CpG island hypermethylation of the FHIT gene in cervical carcinoma. J Gynecol Oncol. 19:117–122. 2008. View Article : Google Scholar : PubMed/NCBI

117 

Özören N and El-Deiry WS: Cell surface death receptor signaling in normal and cancer cells. Semin Cancer Biol. 13:135–147. 2003. View Article : Google Scholar : PubMed/NCBI

118 

Jung S, Yi L, Jeong D, Kim J, An S, Oh TJ, Kim CH, Kim CJ, Yang Y, Kim KI, et al: The role of ADCYAP1, adenylate cyclase activating polypeptide 1, as a methylation biomarker for the early detection of cervical cancer. Oncol Rep. 25:245–252. 2011.PubMed/NCBI

119 

Huang RL, Chang CC, Su PH, Chen YC, Liao YP, Wang HC, Yo YT, Chao TK, Huang HC, Lin CY, et al: Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. PLoS One. 7:e410602012. View Article : Google Scholar : PubMed/NCBI

120 

Ivanova T, Vinokurova S, Petrenko A, Eshilev E, Solovyova N, Kisseljov F and Kisseljova N: Frequent hypermethylation of 5′flanking region of TIMP-2 gene in cervical cancer. Int J Cancer. 108:882–886. 2004. View Article : Google Scholar : PubMed/NCBI

121 

Widschwendter A, Müller HM, Fiegl H, Ivarsson L, Wiedemair A, Müller-Holzner E, Goebel G, Marth C and Widschwendter M: DNA methylation in serum and tumors of cervical cancer patients. Clin Cancer Res. 10:565–571. 2004. View Article : Google Scholar : PubMed/NCBI

122 

Zhai Y, Bommer GT, Feng Y, Wiese AB, Fearon ER and Cho KR: Loss of estrogen receptor 1 enhances cervical cancer invasion. Am J Pathol. 177:884–895. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sen P, Ganguly P and Ganguly N: Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review). Oncol Lett 15: 11-22, 2018.
APA
Sen, P., Ganguly, P., & Ganguly, N. (2018). Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review). Oncology Letters, 15, 11-22. https://doi.org/10.3892/ol.2017.7292
MLA
Sen, P., Ganguly, P., Ganguly, N."Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)". Oncology Letters 15.1 (2018): 11-22.
Chicago
Sen, P., Ganguly, P., Ganguly, N."Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)". Oncology Letters 15, no. 1 (2018): 11-22. https://doi.org/10.3892/ol.2017.7292
Copy and paste a formatted citation
x
Spandidos Publications style
Sen P, Ganguly P and Ganguly N: Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review). Oncol Lett 15: 11-22, 2018.
APA
Sen, P., Ganguly, P., & Ganguly, N. (2018). Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review). Oncology Letters, 15, 11-22. https://doi.org/10.3892/ol.2017.7292
MLA
Sen, P., Ganguly, P., Ganguly, N."Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)". Oncology Letters 15.1 (2018): 11-22.
Chicago
Sen, P., Ganguly, P., Ganguly, N."Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)". Oncology Letters 15, no. 1 (2018): 11-22. https://doi.org/10.3892/ol.2017.7292
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