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Article

Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma

  • Authors:
    • Ganesan Arunkumar
    • Arunagiri Kuha Deva Magendhra Rao
    • Mayakannan Manikandan
    • Harikrishnan Prasanna Srinivasa Rao
    • Shanmugam Subbiah
    • Ramachandran Ilangovan
    • Avaniyapuram Kannan Murugan
    • Arasambattu Kannan Munirajan
  • View Affiliations / Copyright

    Affiliations: Department of Genetics, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India, Center for Oncology, Royapettah Government Hospital and Kilpauk Medical College, Royapettah, Chennai 600014, India, Department of Endocrinology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
  • Pages: 649-657
    |
    Published online on: October 31, 2017
       https://doi.org/10.3892/ol.2017.7296
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Abstract

MicroRNAs (miRNAs) are reported to function as a major component in the cellular signaling circuit, which regulates epithelial‑mesenchymal transition (EMT). Dysregulation of the microRNA‑200 (miR‑200) family and EMT‑associated genes enables tumor metastasis and resistance to therapy. The present study profiled miR‑200 family members miR‑200a, miR‑200b, miR‑200c, miR‑141 and miR‑429, and also several EMT‑regulatory genes including zinc finger E‑box‑binding homeobox (ZEB)1, ZEB2, epithelial cadherin and vimentin in 40 oral primary tumors in order to understand their role(s) in oral squamous cell carcinoma (OSCC). The reverse transcription‑quantitative polymerase chain reaction was used to analyze each sample. Results demonstrated a significant downregulation of miR‑200 family members in tumors with a history of tobacco chewing/smoking (P<0.0006, P=0.0467, P=0.0014, P=0.0087 and P=0.0230, respectively) and undifferentiated pathology (miR‑200a, P=0.0067; miR‑200c, P=0.0248). EMT markers ZEB2 (P=0.0451) and vimentin (P=0.0071) were significantly upregulated in the oral tumors. Furthermore, ZEB2 antisense RNA1 was overexpressed in 50% of OSCC samples (P=0.0075). EMT‑regulatory genes did not exhibit any association with clinical outcome. The present study also analyzed the expression of EMT‑regulatory genes in 523 head and neck squamous cell carcinoma (HNSCC) samples from The Cancer Genome Atlas (TCGA) database, and the association with treatment outcome. Analysis of TCGA datasets also demonstrated no significant association in the expression of EMT markers with disease recurrence and treatment outcome. The results of the present study revealed dysregulation of miR‑200 family miRNAs and EMT‑regulatory genes in OSCC without any significant effect on treatment outcome.
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1 

Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, Horiot JC, Le Maître A, Pajak TF, Poulsen MG, et al: Hyperfractionated or accelerated radiotherapy in head and neck cancer: A meta-analysis. Lancet. 368:843–854. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Huang SH and O'Sullivan B: Oral cancer: Current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal. 8:e233–e240. 2013. View Article : Google Scholar

3 

Peschansky VJ and Wahlestedt C: Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics. 9:3–12. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Tao H, Yang JJ and Shi KH: Non-coding RNAs as direct and indirect modulators of epigenetic mechanism regulation of cardiac fibrosis. Expert Opin Ther Targets. 19:707–716. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lajer CB, Nielsen FC, Friis-Hansen L, Norrild B, Borup R, Garnæs E, Rossing M, Specht L, Therkildsen MH, Nauntofte B, et al: Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: A prospective translational study. Br J Cancer. 104:830–840. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Manikandan M, Magendhra Rao AK Deva, Arunkumar G, Manickavasagam M, Rajkumar KS, Rajaraman R and Munirajan AK: Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism. Mol Cancer. 15:282016. View Article : Google Scholar : PubMed/NCBI

7 

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Han J, Fujisawa T, Husain SR and Puri RK: Identification and characterization of cancer stem cells in human head and neck squamous cell carcinoma. BMC Cancer. 14:1732014. View Article : Google Scholar : PubMed/NCBI

9 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Shrivastava S, Steele R, Sowadski M, Crawford SE, Varvares M and Ray RB: Identification of molecular signature of head and neck cancer stem-like cells. Sci Rep. 5:78192015. View Article : Google Scholar : PubMed/NCBI

11 

Park SM, Gaur AB, Lengyel E and Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes and Dev. 22:894–907. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Tamagawa S, Beder LB, Hotomi M, Gunduz M, Yata K, Grenman R and Yamanaka N: Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. Int J Mol Med. 33:879–786. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Thompson EW, Torri J, Sabol M, Sommers CL, Byers S, Valverius EM, Martin GR, Lippman ME, Stampfer MR and Dickson RB: Oncogene-induced basement membrane invasiveness in human mammary epithelial cells. Clin Exp Metastasis. 12:181–194. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Balbin OA, Malik R, Dhanasekaran SM, Prensner JR, Cao X, Wu YM, Robinson D, Wang R, Chen G, Beer DG, Nesvizhskii AI and Chinnaiyan AM: The landscape of antisense gene expression in human cancers. Genome Res. 25:1068–1079. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33:e1792005. View Article : Google Scholar : PubMed/NCBI

17 

Kang K, Zhang X, Liu H, Wang Z, Zhong J, Huang Z, Peng X, Zeng Y, Wang Y, Yang Y, et al: A novel real-time PCR assay of microRNAs using S-Poly(T), a specific oligo(dT) reverse transcription primer with excellent sensitivity and specificity. PLoS One. 7:e485362012. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y, Pertsemlidis A and Kurie JM: Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 23:2140–2151. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Xu Y, Brenn T, Brown ER, Doherty V and Melton DW: Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors. Br J Cancer. 106:553–561. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Koutsaki M, Spandidos DA and Zaravinos A: Epithelial-mesenchymal transition-associated miRNAs in ovarian carcinoma, with highlight on the miR-200 family: Prognostic value and prospective role in ovarian cancer therapeutics. Cancer Lett. 351:173–181. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Li T, Xie J, Shen C, Cheng D, Shi Y, Wu Z, Deng X, Chen H, Shen B, Peng C, et al: Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene. 35:1575–1584. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR and Hanahan D: MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 23:2152–2165. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Manjari M, Popli R, Paul S, Gupta VP and Kaholon SK: Prevalence of oral cavity, pharynx, larynx and nasal cavity malignancies in Amritsar, Punjab. Indian J Otolaryngol Head Neck Surg. 48:191–195. 1999.

25 

Manikandan M, Magendhra Rao AK Deva, Rajkumar KS, Rajaraman R and Munirajan AK: Altered levels of miR-21, miR-125b-2*, miR-138, miR-155, miR-184, and miR-205 in oral squamous cell carcinoma and association with clinicopathological characteristics. J Oral Pathol Med. 44:792–800. 2015. View Article : Google Scholar : PubMed/NCBI

26 

La DK, Upton PB and Swenberg JA: Carcinogenic alkylating agentsComprehensive Toxicology (revised ed). 12. Pergamon Press; Oxford: pp. 111–140. 2010

27 

Tellez CS, Juri DE, Do K, Bernauer AM, Thomas CL, Damiani LA, Tessema M, Leng S and Belinsky SA: EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res. 71:3087–3097. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW and Hayes DF: Circulating tumor cells, disease progression and survival in metastatic breast cancer. N Engl J Med. 351:781–791. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al: Relationship of circulating tumor cells to tumor response, progression-free survival and overall survival in patients with metastatic colorectal cancer. J Clin Oncol. 26:3213–3221. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Beltran M, Puig I, Peña C, García JM, Álvarez AB, Peña R, Bonilla F and de Herreros AG: A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev. 22:756–769. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D, zur Hausen A, et al: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol. 11:1487–1495. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F, D'Alessio AC, Young RA and Weinberg RA: Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell. 154:61–74. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Liem KF Jr, Jessell TM and Briscoe J: Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development. 127:4855–4866. 2000.PubMed/NCBI

34 

Fischer KR, Durrans A, Lee S, Sheng J, Li F, Wong ST, Choi H, El Rayes T, Ryu S, Troeger J, et al: Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 527:472–476. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS and Kalluri R: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 527:525–530. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Garg M: Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer. World J Stem Cells. 5:188–195. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 25:666–681. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Li W and Kang Y: A new Lnc in metastasis: Long noncoding RNA mediates the prometastatic functions of TGF-β. Cancer Cell. 25:557–559. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Shang Y, Cai X and Fan D: Roles of epithelial-mesenchymal transition in cancer drug resistance. Curr Cancer Drug Targets. 13:915–929. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Arunkumar G, Deva Magendhra Rao AK, Manikandan M, Prasanna Srinivasa Rao H, Subbiah S, Ilangovan R, Murugan AK and Munirajan AK: Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma. Oncol Lett 15: 649-657, 2018.
APA
Arunkumar, G., Deva Magendhra Rao, A.K., Manikandan, M., Prasanna Srinivasa Rao, H., Subbiah, S., Ilangovan, R. ... Munirajan, A.K. (2018). Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma. Oncology Letters, 15, 649-657. https://doi.org/10.3892/ol.2017.7296
MLA
Arunkumar, G., Deva Magendhra Rao, A. K., Manikandan, M., Prasanna Srinivasa Rao, H., Subbiah, S., Ilangovan, R., Murugan, A. K., Munirajan, A. K."Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma". Oncology Letters 15.1 (2018): 649-657.
Chicago
Arunkumar, G., Deva Magendhra Rao, A. K., Manikandan, M., Prasanna Srinivasa Rao, H., Subbiah, S., Ilangovan, R., Murugan, A. K., Munirajan, A. K."Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma". Oncology Letters 15, no. 1 (2018): 649-657. https://doi.org/10.3892/ol.2017.7296
Copy and paste a formatted citation
x
Spandidos Publications style
Arunkumar G, Deva Magendhra Rao AK, Manikandan M, Prasanna Srinivasa Rao H, Subbiah S, Ilangovan R, Murugan AK and Munirajan AK: Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma. Oncol Lett 15: 649-657, 2018.
APA
Arunkumar, G., Deva Magendhra Rao, A.K., Manikandan, M., Prasanna Srinivasa Rao, H., Subbiah, S., Ilangovan, R. ... Munirajan, A.K. (2018). Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma. Oncology Letters, 15, 649-657. https://doi.org/10.3892/ol.2017.7296
MLA
Arunkumar, G., Deva Magendhra Rao, A. K., Manikandan, M., Prasanna Srinivasa Rao, H., Subbiah, S., Ilangovan, R., Murugan, A. K., Munirajan, A. K."Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma". Oncology Letters 15.1 (2018): 649-657.
Chicago
Arunkumar, G., Deva Magendhra Rao, A. K., Manikandan, M., Prasanna Srinivasa Rao, H., Subbiah, S., Ilangovan, R., Murugan, A. K., Munirajan, A. K."Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma". Oncology Letters 15, no. 1 (2018): 649-657. https://doi.org/10.3892/ol.2017.7296
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