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Article Open Access

Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells

  • Authors:
    • Ji‑In Park
    • Kwang‑Soo Kim
    • Sun‑Young Kong
    • Kyung‑Soon Park
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, College of Life Science, CHA University, Seoul 13488, Republic of Korea, Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Seoul 10408, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 55-60
    |
    Published online on: October 31, 2017
       https://doi.org/10.3892/ol.2017.7308
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Abstract

Lymphatic endothelial cells (LEC) are major components of the tumor microenvironment and, due to the relative leakiness of lymphatic vessels compared with blood vessels, are essential for tumor dissemination and metastasis. In the present study, small interfering RNA‑mediated suppression of E26 transformation‑specific domain‑containing protein Elk‑3 (ELK3) inhibited the proliferation, migration and tube‑forming ability of LEC. Suppression of ELK3 decreased vascular endothelial‑cadherin expression levels and increased the phosphorylation of β‑catenin. Furthermore, vascular endothelial growth factor receptor‑3 (VEGFR‑3) mRNA and protein expression levels were suppressed by the transfection of LEC with siELK3. As VEGFR‑3 serves a major role in lymphangiogenesis, ELK3 may be a novel therapeutic target to inhibit tumor dissemination through the lymphatic system.
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Copy and paste a formatted citation
Spandidos Publications style
Park JI, Kim KS, Kong SY and Park KS: Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells. Oncol Lett 15: 55-60, 2018.
APA
Park, J., Kim, K., Kong, S., & Park, K. (2018). Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells. Oncology Letters, 15, 55-60. https://doi.org/10.3892/ol.2017.7308
MLA
Park, J., Kim, K., Kong, S., Park, K."Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells". Oncology Letters 15.1 (2018): 55-60.
Chicago
Park, J., Kim, K., Kong, S., Park, K."Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells". Oncology Letters 15, no. 1 (2018): 55-60. https://doi.org/10.3892/ol.2017.7308
Copy and paste a formatted citation
x
Spandidos Publications style
Park JI, Kim KS, Kong SY and Park KS: Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells. Oncol Lett 15: 55-60, 2018.
APA
Park, J., Kim, K., Kong, S., & Park, K. (2018). Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells. Oncology Letters, 15, 55-60. https://doi.org/10.3892/ol.2017.7308
MLA
Park, J., Kim, K., Kong, S., Park, K."Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells". Oncology Letters 15.1 (2018): 55-60.
Chicago
Park, J., Kim, K., Kong, S., Park, K."Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells". Oncology Letters 15, no. 1 (2018): 55-60. https://doi.org/10.3892/ol.2017.7308
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