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Article

Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI

  • Authors:
    • Mei Wang
    • Congxin Wei
    • Zhaojuan Shi
    • Jianzhong Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Medical Imaging, The Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, P.R. China
  • Pages: 503-508
    |
    Published online on: October 31, 2017
       https://doi.org/10.3892/ol.2017.7313
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Abstract

The present study compared the diagnostic accuracy of multi‑slice spiral computed tomography (CT) and magnetic resonance imaging (MRI) on small hepatocellular carcinoma (SHCC) caused by hepatitis B cirrhosis. A total of 160 patients with hepatitis B cirrhosis were selected between January 2012 and April 2016, and 183 SHCC lesions were included in the present retrospective study. Patients were divided into the SHCC group (T stage) and the micro hepatocellular carcinoma (MHCC) group (T1 stage). There were a total of 129 SHCC lesions and 54 MHCC lesions identified. All patients underwent multiphasic CT and MRI imaging. The liver acquisition with volume acquisition (LAVA) technique was utilized for MRI. Furthermore, SPSS 20.0 was used for statistical analyses. LAVA in the arterial phase and CT in the arterial phase revealed significantly higher diagnostic rates for the diagnoses of 183 lesions. In addition, standard CT scan exhibited significantly reduced diagnostic rates in SHCC lesions. Results indicated that LAVA in the equilibrium phase had the lowest diagnostic rate in MHCC lesions, which was statistically significant (P<0.05). Overall, the diagnostic rate of CT (79.63%) for MHCC was significantly lower than that of MRI (96.29%) (P<0.05). However, the diagnostic rate of CT for SHCC (96.12%) was significantly higher than that for MHCC (79.63%) (P<0.05). MRI‑LAVA in the arterial phase has the highest diagnostic rate for SHCC and MHCC. However, the diagnostic capability of MRI for MHCC lesions is superior to that of CT.
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1 

Fitzmorris P, Shoreibah M, Anand BS and Singal AK: Management of hepatocellular carcinoma. J Cancer Res Clin Oncol. 141:861–876. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Bruix J, Gores GJ and Mazzaferro V: Hepatocellular carcinoma: Clinical frontiers and perspectives. Gut. 63:844–855. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Fernández-Rodríguez CM and Gutiérrez-García ML: Prevention of hepatocellular carcinoma in patients with chronic hepatitis B. World J Gastrointest Pharmacol Ther. 5:175–182. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Hartke J, Johnson M and Ghabril M: The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol. 34:153–159. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Banaudha KK and Verma M: Epigenetic biomarkers in liver cancer. Methods Mol Biol. 1238:65–76. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Thakral S and Ghoshal K: miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir. Curr Gene Ther. 15:142–150. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Cicciù M, Herford AS, Cervino G, Troiano G, Lauritano F and Laino L: Tissue fluorescence imaging (VELscope) for quick non-invasive diagnosis in oral pathology. J Craniofac Surg. 28:e112–e115. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Wang Y, Luo Q, Li Y, Deng S, Wei S and Li X: Radiofrequency ablation versus hepatic resection for small hepatocellular carcinomas: A meta-analysis of randomized and nonrandomized controlled trials. PLoS One. 9:e844842014. View Article : Google Scholar : PubMed/NCBI

9 

Yu MH, Kim JH, Yoon JH, Kim HC, Chung JW, Han JK and Choi BI: Small (≤1-cm) hepatocellular carcinoma: Diagnostic performance and imaging features at gadoxetic acid-enhanced MR imaging. Radiology. 271:748–760. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Hong YM, Yoon KT, Cho M, Heo J, Woo HY and Lim W: A case of small hepatocellular carcinoma with an extensive lymph node metastasis at diagnosis. Clin Mol Hepatol. 20:310–312. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Jiang YY, Wang XY, Guo XM and Jiang XX: Small hepatocellular carcinoma in patients with hepatitis B-induced cirrhosis: a comparison between MRI and MDCT. Beijing Da Xue Xue Bao. 42:767–772. 2010.(Article in Chinese). PubMed/NCBI

12 

Kim JM, Kwon CH, Joh JW, Park JB, Lee JH, Kim SJ, Paik SW, Park CK and Yoo BC: Differences between hepatocellular carcinoma and hepatitis B virus infection in patients with and without cirrhosis. Ann Surg Oncol. 21:458–465. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Lv P, Lin XZ, Li J, Li W and Chen K: Differentiation of small hepatic hemangioma from small hepatocellular carcinoma: Recently introduced spectral CT method. Radiology. 259:720–729. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Choi BI, Takayasu K and Han MC: Small hepatocellular carcinomas and associated nodular lesions of the liver: Pathology, pathogenesis, and imaging findings. AJR Am J Roentgenol. 160:1177–1187. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y, Gao Y, Shi W, Zhai D, Rao Q, Jia X, Liu J, Jiao X and Du Z: Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma. Cancer Biomark. 15:171–180. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Hagel M, Miduturu C, Sheets M, Rubin N, Weng W, Stransky N, Bifulco N, Kim JL, Hodous B, Brooijmans N, et al: First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway. Cancer Discov. 5:424–437. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Wang R, Luo Y, Yang S, Lin J, Gao D, Zhao Y, Liu J, Shi X and Wang X: Hyaluronic acid-modified manganese-chelated dendrimer-entrapped gold nanoparticles for the targeted CT/MR dual-mode imaging of hepatocellular carcinoma. Sci Rep. 6:338442016. View Article : Google Scholar : PubMed/NCBI

18 

Sattler B, Lee JA, Lonsdale M and Coche E: PET/CT (and CT) instrumentation, image reconstruction and data transfer for radiotherapy planning. Radiother Oncol. 96:288–297. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Chou CT, Chen RC, Lin WC, Ko CJ, Chen CB and Chen YL: Prediction of microvascular invasion of hepatocellular carcinoma: Preoperative CT and histopathologic correlation. AJR Am J Roentgenol. 203:W253–W259. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Liu JJ, Li HX, Chen ZB, Yang WP, Zhao SF, Chen J, Bai T, Li H and Li LQ: Consistency analysis of contrast-enhanced ultrasound and contrast-enhanced CT in diagnosis of small hepatocellular carcinoma. Int J Clin Exp Med. 8:21466–21471. 2015.PubMed/NCBI

21 

Sahinarslan A, Erbas G, Kocaman SA, Bas D, Akyel A, Karaer D, Ergun MA, Arac M and Boyaci B: Comparison of radiation-induced damage between CT angiography and conventional coronary angiography. Acta Cardiol. 68:291–297. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Schiebler ML, Bhalla S, Runo J, Jarjour N, Roldan A, Chesler N and François CJ: Magnetic resonance and computed tomography imaging of the structural and functional changes of pulmonary arterial hypertension. J Thorac Imaging. 28:178–193. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Zhao XT, Li WX, Chai WM and Chen KM: Detection of small hepatocellular carcinoma using gadoxetic acid-enhanced MRI: Is the addition of diffusion-weighted MRI at 3. 0T beneficial? J Dig Dis. 15:137–145. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Hwang J, Kim SH, Lee MW and Lee JY: Small (≤2 cm) hepatocellular carcinoma in patients with chronic liver disease: Comparison of gadoxetic acid-enhanced 3.0 T MRI and multiphasic 64-multirow detector CT. Br J Radiol. 85:e314–e322. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Wei C, Shi Z and Zhu J: Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI. Oncol Lett 15: 503-508, 2018.
APA
Wang, M., Wei, C., Shi, Z., & Zhu, J. (2018). Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI. Oncology Letters, 15, 503-508. https://doi.org/10.3892/ol.2017.7313
MLA
Wang, M., Wei, C., Shi, Z., Zhu, J."Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI". Oncology Letters 15.1 (2018): 503-508.
Chicago
Wang, M., Wei, C., Shi, Z., Zhu, J."Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI". Oncology Letters 15, no. 1 (2018): 503-508. https://doi.org/10.3892/ol.2017.7313
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Wei C, Shi Z and Zhu J: Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI. Oncol Lett 15: 503-508, 2018.
APA
Wang, M., Wei, C., Shi, Z., & Zhu, J. (2018). Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI. Oncology Letters, 15, 503-508. https://doi.org/10.3892/ol.2017.7313
MLA
Wang, M., Wei, C., Shi, Z., Zhu, J."Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI". Oncology Letters 15.1 (2018): 503-508.
Chicago
Wang, M., Wei, C., Shi, Z., Zhu, J."Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI". Oncology Letters 15, no. 1 (2018): 503-508. https://doi.org/10.3892/ol.2017.7313
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