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Article

Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas

  • Authors:
    • Ting‑Ting Liu
    • Hao Wang
    • Feng Juan Wang
    • Yu Feng Xi
    • Li Hua Chen
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China, Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 533-537
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/ol.2017.7333
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Abstract

Neurotrophic factors (NTFs) are well known to serve critical functions in neural survival, neurite growth and cell differentiation in vivo and in vitro. Previous progress has indicated that nerve growth factor (NGF) and brain‑derived neurotrophic factor (BDNF), two NTF family members, may be involved in the process of tumor progression. In the present study, the expression of NGF and BDNF was detected using immunohistochemistry on 70 adult astrocytoma samples collected from distinct locations as well as of various pathological grades, with an additional 15 samples being collected from normal adult brain tissue to be used as controls. NGF and BDNF were identified to be expressed in all samples, and their positive cell expression rates in astrocytomas demonstrated a significant increase compared with that in the normal controls (P<0.05), particularly in grade III (P<0.05). In addition, the expression of NGF and BDNF exhibited a gradual decrease ranging from the temporal lobe, parietal lobe and cerebellum to the frontal lobe (P<0.05). The results of the present study suggest that the expression of NGF and BDNF is increased in astrocytomas, which is associated with the pathological grade and the astrocytoma location.
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1 

Chiaretti A, Aloe L, Antonelli A, Ruggiero A, Piastra M, Riccardi R, Tamburrini G and Di Rocco C: Neurotrophic factor expression in childhood low-grade astrocytomas and ependymomas. Childs Nerv Syst. 20:412–419. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Aloe L, Tirassa P and Bracci-Laudiero L: Nerve growth factor in neurological and non-neurological diseases: Basic findings and emerging pharmacological prospectives. Curr Pharm Des. 7:113–123. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Drago J, Kilpatrick TJ, Koblar SA and Talman PS: Growth factor: Potential therapeutic applications in neurology. J Neurol Neurosurg Psychiatry. 57:1445–1450. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Levi-Montalcini R: The nerve growth factor 35 years later. Science. 237:1154–1162. 1987. View Article : Google Scholar : PubMed/NCBI

5 

Thoenen H, Bandtlow C and Heumann R: The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery. Rev Physiol Biochem Pharmacol. 109:145–178. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Barde YA: Neurotrophins: A family of proteins supporting the survival of neurons. Prog Clin Biol Res. 390:45–56. 1994.PubMed/NCBI

7 

Sofroniew MV, Howe CL and Mobley WC: Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 24:1217–1281. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Korsching S, Auburger G, Heumann R, Scott J and Thoenen H: Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation. Embo J. 4:1389–1393. 1985.PubMed/NCBI

9 

Connor B and Dragunow M: The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res Brain Res Rev. 27:1–39. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Levi-Montalcini A and Angeletti PU: Nerve growth factor. Physiol Rev. 48:534–569. 1968.PubMed/NCBI

11 

Chao MV and Hempstead BL: p75 and Trk: A two-receptor system. Trends Neurosci. 18:321–326. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Z, Yang Y, Gong A, Wang C, Liang Y and Chen Y: Localization of NGF and TrkA at mitotic apparatus in human astrocytoma cell line u251. Biochem Biophys Res Commun. 337:68–74. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Friedman WJ, Ibáñez CF, Hallböök F, Persson H, Cain LD, Dreyfus CF and Black IB: Differential actions of neurotrophins in the locus corelueus and basal forebrain. Exp Neurol. 119:72–78. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Mamounas LA, Blue ME, Siuciak JA and Altar CA: Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci. 15:7929–7939. 1995.PubMed/NCBI

15 

Siuciak JA, Altar CA, Wiegand SJ and Lindsay RM: Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3. Brain Res. 633:326–330. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Sklair-Tavron L and Nestler EJ: Opposing effects of morphine and the neurotrophins, NT-3, NT-4, and BDNF, on locus coeruleus neurons in vitro. Brain Res. 702:117–125. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Juric DM, Miklic S and Carman-Krzan M: Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain Res. 1108:54–62. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Baloh RH, Enomoto H, Johnson EM Jr and Milbrandt J: The GDNF family ligands and receptors-implications for neural development. Curr Opin Neurobiol. 10:103–110. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Yang ZF, Ho DW, Lau CK, Tam KH, Lam CT, Yu WC, Poon RT and Fan ST: Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma. Oncol Rep. 16:1237–1243. 2006.PubMed/NCBI

20 

Tapia-Arancibia L, Rage F, Givalois L and Arancibia S: Physiology of BDNF: Focus on hypothalamic function. Front Neuroendocrinol. 25:77–107. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Matsumoto K, Yamamoto K, Karasawa Y, Hino N, Nakamura A, Takahashi M, Araki H, Okuyama S, Choshi T, Sugino E, et al: Possible involvement of induction of brain-derived neurotrophic factor in the neuroprotective effect of a 5-phenylpyrimidine derivative. Biochem Pharmacol. 66:1019–1023. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Renné C, Willenbrock K, Küppers R, Hansmann ML and Bräuninger A: Autocrine and paracrine-activated receptor tyrosine kinases in classic hodgkin lymphoma. Blood. 105:4051–4059. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Pearse RN, Swendeman SL, Li Y, Rafii D and Hempstead BL: A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 105:4429–4436. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E and Peeper DS: Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature. 430:1034–1039. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Grotzer MA, Janss AJ, Fung K, Biegel JA, Sutton LN, Rorke LB, Zhao H, Cnaan A, Phillips PC, Lee VM and Trojanowski JQ: TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol. 18:1027–1035. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Segal RA, Goumnerova LC, Kwon YK, Stiles CD and Pomeroy SL: Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci USA. 91:pp. 12867–12871. 1994; View Article : Google Scholar : PubMed/NCBI

27 

Chiappa SA, Chin LS, Zurawel RH and Raffel C: Neurotrophins and Trk receptors in primitive neuroectodermal tumor cell lines. Neurosurgery. 45:1148–1155. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Colucci-D'Amato GL, D'Alessio A, Califano D, Cali G, Rizzo C, Nitsch L, Santelli G and de Franciscis V: Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK. J Biol Chem. 275:19306–19314. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Devouassoux-Shisheboran M, Mauduit C, Tabone E, Droz JP and Benahmed M: Growth regulatory factors and signalling proteins in testicular germ cell tumours. APMIS. 111:212–224. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Eggert A, Sieverts H, Ikegaki N and Brodeur GM: P75 mediated apoptosis in neuroblastoma cells is inhibited by expression of TrkA. Med Pediatr Oncol. 35:573–576. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Goustin AS, Leof EB, Shipley GD and Moses HL: Growth factors and cancer. Cancer Res. 46:1015–1029. 1986.PubMed/NCBI

32 

Nishio S, Morioka T, Hamada Y, Fukui M and Nakagawara A: Immunohistochemical expression of tyrosine kinase (Trk) receptor proteins in mature neuronal cell tumors of the central nervous system. Clin Neuropathol. 17:123–130. 1998.PubMed/NCBI

33 

Zhu Z, Friess H, diMola FF, Zimmermann A, Graber HU, Korc M and Büchler MW: Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. J Clin Oncol. 17:2419–2428. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Zhu ZW, Friess H, Wang L, Di Mola FF, Zimmermann A and Büchler MW: Down-regulation of nerve growth factor in poorly differentiated and advanced human esophageal cancer. Anticancer Res. 20:125–132. 2000.PubMed/NCBI

35 

Dollé L, ElYazidi-Belkoura I, Adriaenssens E, Nurcombe V and Hondermarck H: Nerve growth factor overexpression and autocrine loop in breast cancer cells. Oncogene. 22:5592–5601. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Breit S, Ashman K, Wilting J, Rössler J, Hatzi E, Fotsis T and Schweigerer L: The N-myc oncogene in human neuroblastoma cells: Down-regulation of an angiogenesis inhibitor identified as activin. Cancer Res. 60:4596–4601. 2000.PubMed/NCBI

37 

Zhang J, Zhang J, Li A and Fan Y: Role of nerve growth factor receptor in neuroblastoma angiogenesis. Chinese J Contemporary Pediatrics. 6:93–98. 2004.

38 

Hu Y, Sun CY, Wang HF, Guo T, Wei WN, Wang YD, He WJ, Wu T, Tan H and Wu TC: Brain-derived neurotrophic factor promotes growth and migration of multiple myeloma cells. Cancer Genet Cytogenet. 169:12–20. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Qiu L, Zhou C, Sun Y, Di W, Scheffler E, Healey S, Kouttab N, Chu W and Wan Y: Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation. Int J Oncol. 29:1003–1011. 2006.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu TT, Wang H, Wang FJ, Xi YF and Chen LH: Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas. Oncol Lett 15: 533-537, 2018.
APA
Liu, T., Wang, H., Wang, F.J., Xi, Y.F., & Chen, L.H. (2018). Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas. Oncology Letters, 15, 533-537. https://doi.org/10.3892/ol.2017.7333
MLA
Liu, T., Wang, H., Wang, F. J., Xi, Y. F., Chen, L. H."Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas". Oncology Letters 15.1 (2018): 533-537.
Chicago
Liu, T., Wang, H., Wang, F. J., Xi, Y. F., Chen, L. H."Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas". Oncology Letters 15, no. 1 (2018): 533-537. https://doi.org/10.3892/ol.2017.7333
Copy and paste a formatted citation
x
Spandidos Publications style
Liu TT, Wang H, Wang FJ, Xi YF and Chen LH: Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas. Oncol Lett 15: 533-537, 2018.
APA
Liu, T., Wang, H., Wang, F.J., Xi, Y.F., & Chen, L.H. (2018). Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas. Oncology Letters, 15, 533-537. https://doi.org/10.3892/ol.2017.7333
MLA
Liu, T., Wang, H., Wang, F. J., Xi, Y. F., Chen, L. H."Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas". Oncology Letters 15.1 (2018): 533-537.
Chicago
Liu, T., Wang, H., Wang, F. J., Xi, Y. F., Chen, L. H."Expression of nerve growth factor and brain‑derived neurotrophic factor in astrocytomas". Oncology Letters 15, no. 1 (2018): 533-537. https://doi.org/10.3892/ol.2017.7333
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