Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells

Retraction in: /10.3892/ol.2023.13919
  • Authors:
    • Yayun Qian
    • Songhua Lu
    • Youyang Shi
    • Xueyu Zhao
    • Ting Yang
    • Feng Jin
    • Yanqing Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 243-249
    |
    Published online on: November 3, 2017
       https://doi.org/10.3892/ol.2017.7341
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Celastrus orbiculatus Thunb. has been used as a remedy against cancer and inflammatory diseases for thousands of years in China. Maspin is expressed in normal cells and downregulated in prostate tumor cells. The underlying mechanisms between C. orbiculatus extract (COE) and maspin remain unclear. In the present study, 3 target‑specific 19‑25 nucleotide maspin small interfering RNAs were designed and synthesized to knockdown maspin expression. The effects of COE on MGC‑803/maspin‑ cell proliferation were evaluated by the MTT assay. Apoptosis was measured by flow cytometry. Invasive activity was measured with the Transwell assay and the associated molecular mechanisms were assessed by western blot analysis. The results demonstrated that COE significantly promoted the expression of maspin (P<0.01) to induce apoptosis and inhibit invasion and migration in MGC803 cells. The expression levels of phosphorylated (p)‑p38 mitogen‑activated protein kinase (MAPK), phospho‑extracellular regulated protein kinase (Erk), B cell lymphoma-2‑associated X protein and caspase‑3 were increased in the MGC‑803/maspin‑ cells in a dose‑dependent manner. The Erk, B‑cell lymphoma 2, p‑Akt, Akt and p‑mechanistic target of rapamycin (mTOR) protein in MGC‑803/maspin‑ cells were reduced in a dose‑dependent manner. This indicated that COE may inhibit invasion and migration through phosphoinositide 3‑kinase/Akt/mTOR and MAPK signaling pathways in MGC‑803/maspin‑ cells. In conclusion, COE has the ability to improve the expression of maspin to induce apoptosis and inhibit invasion and migration in human gastric adenocarcinoma cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Wu HH, Lin W and Tsai KW: Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev Mol Med. 16:e12014. View Article : Google Scholar : PubMed/NCBI

2 

Kim SJ, Wang YG, Lee HW, Kang HG, La SH, Choi IJ, Irimura T, Ro JY, Bresalier RS and Chun KH: Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer. Oncotarget. 5:3386–3398. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kanat O and O'Neil BH: Metastatic gastric cancer treatment: A little slow but worthy progress. Med Oncol. 30:4642013. View Article : Google Scholar : PubMed/NCBI

4 

Zhu YD, Liu YQ, Qian YY, Zhang H, Li GQ and Yang L: Extracts of Celastrus orbiculatus exhibit anti-proliferative and anti-invasive effects on human gastricadenocarcinoma cells. Chin J Integr Med. Nov 10–2014.(Epub ahead of print). View Article : Google Scholar

5 

Wang S, Zhong Z, Wan J, Tan W, Wu G, Chen M and Wang Y: Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am J Chin Med. 41:177–196. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Tarakji B, Ashok N, Sheirawan MK, Altamimi MA, Alenzi F, Azzeghaiby SN, Baroudi K and Nassani MZ: Maspin as a tumour suppressor in salivary gland tumour. J Clin Diagn Res. 8:ZE05–ZE07. 2014.PubMed/NCBI

7 

Bodenstine TM, Seftor RE, Seftor EA, Khalkhali-Ellis Z, Samii NA, Monarrez JC, Chandler GS, Pemberton PA and Hendrix MJ: Internalization by multiple endocytic pathways and lysosomal processing impact maspin-based therapeutics. Mol Cancer Res. 12:1480–1491. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Lovato A, Lionello M, Staffieri A, Blandamura S, Tealdo G, Giacomelli L, Staffieri C and Marioni G: A higher angiogenin expression is associated with a nonnuclear maspin location in laryngeal carcinoma. Clin Exp Otorhinolaryngol. 8:268–274. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Bagheri M, Eghtedari M, Bagheri M, Geramizadeh B and Talebnejad M: Expression of Maspin and Ezrin proteins in periocular basal cell carcinoma. Dermatol Res Pract. 2014:5965642014.PubMed/NCBI

10 

Dzinic SH, Chen K, Thakur A, Kaplun A, Bonfil RD, Li X, Liu J, Bernardo MM, Saliganan A, Back JB, et al: Maspin expression in prostate tumor elicits host anti-tumor immunity. Oncotarget. 5:11225–11236. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Lonardo F, Guan H, Dzinic S and Sheng S: Maspin expression patterns differ in the invasive versus lepidic growth pattern of pulmonary adenocarcinoma. Histopathology. 65:757–763. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Wang WM, Liu YQ and Dai XJ: Apoptosis of Hela cell induced by Celastrus orbiculatus Thunb extract and primary mechanisms. Chin-German J Clin Oncol. 10:666–668. 2011. View Article : Google Scholar

13 

Qian YY, Zhang H, Hou Y, Yuan L, Li GQ, Guo SY, Hisamits T and Liu YQ: Celastrus orbiculatus extract inhibits tumor angiogenesis by targeting vascular endothelial growth factor signaling pathway and shows potent antitumor activity in hepatocarcinomas in vitro and in vivo. Chin J Integr Med. 18:752–760. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Ma H, Qian YY, Zhang H, Xue JI, Yaodong ZHU, Pingfang CUI and Yanqing LIU: Celastrus orbiculatus extract could inhibit human colorectal carcinoma HT-29 cells metastasis via suppression of the mTOR signaling pathway. Life Sci J. 10:1704–1710. 2013.

15 

Zhang H, Qian Y, Liu Y, Li G, Cui P, Zhu Y, Ma H, Ji X, Guo S and Tadashi H: Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells. J Tradit Chin Med. 32:621–626. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Hong M, Wang N, Tan HY, Tsao SW and Feng Y: MicroRNAs and Chinese medicinal herbs: New possibilities in cancer therapy. Cancers (Basel). 7:1643–1657. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Su CX, Wang LQ, Grant SJ and Liu JP: Chinese herbal medicine for cancer-related fatigue: A systematic review of randomized clinical trials. Complement Ther Med. 22:567–579. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Chen CM, Lin LZ and Zhang EX: Standardized treatment of Chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study. Chin J Integr Med. 20:496–502. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Luo FR, Ding J, Chen HX, Liu H, Fung MC, Koehler M, Armand JP, Jiang L, Xu X, Zhang G, et al: Breakthrough cancer medicine and its impact on novel drug development in China: Report of the US Chinese anti-cancer association (USCACA) and Chinese society of clinical oncology (Csco) joint session at the 17th CSCO annual meeting. Chin J Cancer. 33:620–624. 2014.PubMed/NCBI

21 

Zhu Y, Liu Y, Qian Y, Dai X, Yang L, Chen J, Guo S and Hisamitsu T: Antimetastatic effects of Celastrus orbiculatus on humangastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway. Integr Cancer Ther. 14:271–281. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Zhu Y, Liu Y, Qian Y, Dai X, Yang L, Chen J, Guo S and Hisamitsu T: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma. BMC Complement Altern Med. 14:4332014. View Article : Google Scholar : PubMed/NCBI

23 

Wang M, Zhang X, Xiong X, Yang Z, Sun Y, Yang Z, Hoffman RM and Liu Y: Efficacy of the Chinese traditional medicinal herb Celastrus orbiculatus Thunb on human hepatocellular carcinoma in an orthothopic fluorescent nude mouse model. Anticancer Res. 32:1213–1220. 2012.PubMed/NCBI

24 

Jeon H: Anti-metastatic effects of celastrus orbiculatus extract in B16F10 melanoma cells. Nat Prod Sci. 17:135–141. 2011.

25 

Jin X and Shi YI: Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Exp Ther Med. 11:403–408. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Nguyen KC, Willmore WG and Tayabali AF: Cadmium tellunde quantum dots cause oxidative stress leading to extnnsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells. Toxicology. 306:114–123. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Wu R, Duan L, Ye L, Wang H, Yang X, Zhang Y, Chen X, Zhang Y, Weng Y, Luo J, et al: S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway. Int J Oncol. 42:1001–1010. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qian Y, Lu S, Shi Y, Zhao X, Yang T, Jin F and Liu Y: Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919. Oncol Lett 15: 243-249, 2018.
APA
Qian, Y., Lu, S., Shi, Y., Zhao, X., Yang, T., Jin, F., & Liu, Y. (2018). Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919. Oncology Letters, 15, 243-249. https://doi.org/10.3892/ol.2017.7341
MLA
Qian, Y., Lu, S., Shi, Y., Zhao, X., Yang, T., Jin, F., Liu, Y."Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919". Oncology Letters 15.1 (2018): 243-249.
Chicago
Qian, Y., Lu, S., Shi, Y., Zhao, X., Yang, T., Jin, F., Liu, Y."Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919". Oncology Letters 15, no. 1 (2018): 243-249. https://doi.org/10.3892/ol.2017.7341
Copy and paste a formatted citation
x
Spandidos Publications style
Qian Y, Lu S, Shi Y, Zhao X, Yang T, Jin F and Liu Y: Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919. Oncol Lett 15: 243-249, 2018.
APA
Qian, Y., Lu, S., Shi, Y., Zhao, X., Yang, T., Jin, F., & Liu, Y. (2018). Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919. Oncology Letters, 15, 243-249. https://doi.org/10.3892/ol.2017.7341
MLA
Qian, Y., Lu, S., Shi, Y., Zhao, X., Yang, T., Jin, F., Liu, Y."Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919". Oncology Letters 15.1 (2018): 243-249.
Chicago
Qian, Y., Lu, S., Shi, Y., Zhao, X., Yang, T., Jin, F., Liu, Y."Celastrus orbiculatus extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells Retraction in /10.3892/ol.2023.13919". Oncology Letters 15, no. 1 (2018): 243-249. https://doi.org/10.3892/ol.2017.7341
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team