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Article Open Access

Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance

  • Authors:
    • Chenglong Wang
    • Qian Ye
    • Yijia Cao
    • Juan Tan
    • Fei Wang
    • Jin Jiang
    • Youde Cao
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, P.R. China, Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, P.R. China , Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 213-220
    |
    Published online on: November 3, 2017
       https://doi.org/10.3892/ol.2017.7351
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Abstract

Changes in the expression of regulator of G protein signaling 2 (RGS2) are involved in the genesis and development of a number of malignancies. However, the association between changes in the expression of RGS2 and breast invasive carcinoma of no special type (BIC‑NST) remains unknown. The present study found that, in comparison to normal breast tissue, BIC‑NST exhibited low expression of RGS2 mRNA and protein, as detected using data mining and immunohistochemical analysis. The low expression of RGS2 was associated with the positive status of hormone receptor expression in BIC‑NST. Kaplan‑Meier analysis revealed that patients with low RGS2 expression had a significantly poorer overall survival rate. Furthermore, multivariate Cox regression analysis demonstrated that the RGS2 low expression was an independent high‑risk factor. Gene set enrichment analysis using data from The Cancer Genome Atlas supported these results. In summary, the results of the current study indicate that RGS2 acts as a suppressor gene in the progression of BIC‑NST. To the best of our knowledge, the present study is the first concerning the association between RGS2 and hormone receptors in BIC‑NST, as well as that between RGS2 expression and the prognosis of patients with BIC‑NST. However, the effect of RGS2 in breast cancer requires further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Ye Q, Cao Y, Tan J, Wang F, Jiang J and Cao Y: Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance. Oncol Lett 15: 213-220, 2018.
APA
Wang, C., Ye, Q., Cao, Y., Tan, J., Wang, F., Jiang, J., & Cao, Y. (2018). Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance. Oncology Letters, 15, 213-220. https://doi.org/10.3892/ol.2017.7351
MLA
Wang, C., Ye, Q., Cao, Y., Tan, J., Wang, F., Jiang, J., Cao, Y."Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance". Oncology Letters 15.1 (2018): 213-220.
Chicago
Wang, C., Ye, Q., Cao, Y., Tan, J., Wang, F., Jiang, J., Cao, Y."Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance". Oncology Letters 15, no. 1 (2018): 213-220. https://doi.org/10.3892/ol.2017.7351
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Ye Q, Cao Y, Tan J, Wang F, Jiang J and Cao Y: Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance. Oncol Lett 15: 213-220, 2018.
APA
Wang, C., Ye, Q., Cao, Y., Tan, J., Wang, F., Jiang, J., & Cao, Y. (2018). Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance. Oncology Letters, 15, 213-220. https://doi.org/10.3892/ol.2017.7351
MLA
Wang, C., Ye, Q., Cao, Y., Tan, J., Wang, F., Jiang, J., Cao, Y."Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance". Oncology Letters 15.1 (2018): 213-220.
Chicago
Wang, C., Ye, Q., Cao, Y., Tan, J., Wang, F., Jiang, J., Cao, Y."Downregulation of regulator of G protein signaling 2 expression in breast invasive carcinoma of no special type: Clinicopathological associations and prognostic relevance". Oncology Letters 15, no. 1 (2018): 213-220. https://doi.org/10.3892/ol.2017.7351
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