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MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer

  • Authors:
    • Ling Zhang
    • Xiangming Chen
    • Baoli Liu
    • Junqing Han
  • View Affiliations / Copyright

    Affiliations: Department of Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250000, P.R. China, Department of Clinical Oncology, Taian City Central Hospital, Taian, Shandong 271000, P.R. China, Department of Medical Insurance, Taian City Central Hospital, Taian, Shandong 271000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 984-990
    |
    Published online on: November 8, 2017
       https://doi.org/10.3892/ol.2017.7358
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Abstract

Breast cancer (BC) is the leading cause of cancer‑associated mortality among women worldwide, with a poor 5‑year survival rate, particularly among patients with metastatic BC. Previous studies have indicated that the dysregulation of microRNAs (miRNAs/miRs) is associated with carcinogenesis and metastasis. Thus, investigating the underlying molecular mechanisms by which miRNAs mediate their effects may aid in the improvement of BC treatment. In the present study, reverse transcription‑quantitative polymerase chain reaction analyses were performed to investigate miR‑124‑3p expression in BC tissues. The expression of miR‑124‑3p was significantly decreased in primary BC tissues compared with that in adjacent non‑tumor tissues. Downregulated miR‑124‑3p was correlated with lymph node metastasis and a low overall survival time. Wound‑healing and Transwell assays revealed that MDA‑MB‑231 and MCF‑7 cell motility was inhibited by miR‑124‑3p, but was promoted by a miR‑124‑3p inhibitor. Overexpression of miR‑124‑3p increased levels of E‑cadherin, and decreased levels of N‑cadherin and Vimentin, indicating that miR‑124‑3p inhibits the epithelial‑mesenchymal transition. In addition, a bioinformatics analysis and subsequent in vitro experiments identified programmed cell death protein 6 (PDCD6) as a direct target of miR‑124‑3p. Restoration of PDCD6 expression impaired the metastasis inhibitor role of miR‑124‑3p by promoting cell invasion. Furthermore, the expression of miR‑124‑3p was inversely associated with PDCD6 mRNA levels in clinical breast tumors. Taken together, these data suggest that miR‑124‑3p inhibits tumor metastasis by inhibiting PDCD6 expression, and that the miR‑124‑3p/PDCD6 signaling axis may be a potential target for novel treatments in patients with advanced BC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ha R, Chow D and Wynn R: Global trend in breast cancer imaging research 1992–2012: Bibliometric study. AJR Am J Roentgenol. 202:696–697. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, Bannon F, Ahn JV, Johnson CJ, Bonaventure A, et al: Global surveillance of cancer survival 1995–2009: Analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 385:977–1010. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Ge L, Zheng B, Li M, Niu L and Li Z: MicroRNA-497 suppresses osteosarcoma tumor growth in vitro and in vivo. Oncol Lett. 11:2207–2212. 2016.PubMed/NCBI

5 

Liu Z, Gersbach E, Zhang X, Xu X, Dong R, Lee P, Liu J, Kong B, Shao C and Wei JJ: miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma. Mol Cancer Res. 11:1314–1325. 2013. View Article : Google Scholar : PubMed/NCBI

6 

He J, Zhang W, Zhou Q, Zhao T, Song Y, Chai L and Li Y: Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4. Int J Biochem Cell Biol. 45:1962–1973. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Shen B, Zhang Y, Yu S, Yuan Y, Zhong Y, Lu J and Feng J: MicroRNA-339, an epigenetic modulating target is involved in human gastric carcinogenesis through targeting NOVA1. FEBS Lett. 589:3205–3211. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Li Y, Xu D, Bao C, Zhang Y, Chen D, Zhao F, Ding J, Liang L, Wang Q, Liu L, et al: MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget. 6:2421–2433. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kan H, Guo W, Huang Y and Liu D: MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7. FEBS Lett. 589:102–109. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Simbrich A, Wellmann I, Heidrich J, Heidinger O and Hense HW: Trends in advanced breast cancer incidence rates after implementation of a mammography screening program in a German population. Cancer Epidemiol. 44:44–51. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Su D, Xu H, Feng J, Gao Y, Gu L, Ying L, Katsaros D, Yu H, Xu S and Qi M: PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer. J Transl Med. 10:312012. View Article : Google Scholar : PubMed/NCBI

13 

Yang Q, Wang Y, Lu X, Zhao Z, Zhu L, Chen S, Wu Q, Chen C and Wang Z: MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells. Oncotarget. 6:3268–3279. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Sahlberg K Kleivi, Bottai G, Naume B, Burwinkel B, Calin GA, Børresen-Dale AL and Santarpia L: A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients. Clin Cancer Res. 21:1207–1214. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR and Zhao Q: MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Carcinogenesis. 34:713–722. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Dong LL, Chen LM, Wang WM and Zhang LM: Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer. Diagn Pathol. 10:452015. View Article : Google Scholar : PubMed/NCBI

17 

Li L, Luo J, Wang B, Wang D, Xie X, Yuan L, Guo J, Xi S, Gao J, Lin X, et al: Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer. Mol Cancer. 12:1632013. View Article : Google Scholar : PubMed/NCBI

18 

Arabkheradmand A, Safari A, Seifoleslami M, Yahaghi E and Gity M: Down-regulated microRNA-124 expression as predictive biomarker and its prognostic significance with clinicopathological features in breast cancer patients. Diagn Pathol. 10:1782015. View Article : Google Scholar : PubMed/NCBI

19 

Li H, Xie S, Liu M, Chen Z, Liu X, Wang L, Li D and Zhou Y: The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis. Int J Oncol. 45:197–208. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Li X, Yu Z, Li Y, Liu S, Gao C, Hou X, Yao R and Cui L: The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients. Int J Oncol. 46:798–808. 2015. View Article : Google Scholar : PubMed/NCBI

21 

An L, Liu Y, Wu A and Guan Y: microRNA-124 inhibits migration and invasion by down-regulating ROCK1 in glioma. PLoS One. 8:e694782013. View Article : Google Scholar : PubMed/NCBI

22 

Zhang H, Wang Q, Zhao Q and Di W: MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1. J Ovarian Res. 6:842013. View Article : Google Scholar : PubMed/NCBI

23 

Peng XH, Huang HR, Lu J, Liu X, Zhao FP, Zhang B, Lin SX, Wang L, Chen HH, Xu X, et al: MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma. Mol Cancer. 13:1862014. View Article : Google Scholar : PubMed/NCBI

24 

Zhang W, Mao YQ, Wang H, Yin WJ, Zhu SX and Wang WC: MiR-124 suppresses cell motility and adhesion by targeting talin 1 in prostate cancer cells. Cancer Cell Int. 15:492015. View Article : Google Scholar : PubMed/NCBI

25 

la Cour JM, Høj BR, Mollerup J, Simon R, Sauter G and Berchtold MW: The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. Mol Oncol. 1:431–439. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Chen X, Liu B and Han J: MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer. Oncol Lett 15: 984-990, 2018.
APA
Zhang, L., Chen, X., Liu, B., & Han, J. (2018). MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer. Oncology Letters, 15, 984-990. https://doi.org/10.3892/ol.2017.7358
MLA
Zhang, L., Chen, X., Liu, B., Han, J."MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer". Oncology Letters 15.1 (2018): 984-990.
Chicago
Zhang, L., Chen, X., Liu, B., Han, J."MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer". Oncology Letters 15, no. 1 (2018): 984-990. https://doi.org/10.3892/ol.2017.7358
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Chen X, Liu B and Han J: MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer. Oncol Lett 15: 984-990, 2018.
APA
Zhang, L., Chen, X., Liu, B., & Han, J. (2018). MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer. Oncology Letters, 15, 984-990. https://doi.org/10.3892/ol.2017.7358
MLA
Zhang, L., Chen, X., Liu, B., Han, J."MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer". Oncology Letters 15.1 (2018): 984-990.
Chicago
Zhang, L., Chen, X., Liu, B., Han, J."MicroRNA‑124‑3p directly targets PDCD6 to inhibit metastasis in breast cancer". Oncology Letters 15, no. 1 (2018): 984-990. https://doi.org/10.3892/ol.2017.7358
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