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Article

TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax

  • Authors:
    • Lanlan Wan
    • Daqi Zhang
    • Jinnan Zhang
    • Liqun Ren
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Thyroid Surgery, China‑Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin 130033, P.R. China, Department of Neurosurgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Pharmacology and Toxicology, Jilin University School of Pharmaceutical Sciences, Changchun, Jilin 130021, P.R. China
  • Pages: 1271-1278
    |
    Published online on: November 8, 2017
       https://doi.org/10.3892/ol.2017.7366
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Abstract

Melittin is a 26 amino acid residue antimicrobial peptide with known antitumor activity. In the present study, a novel peptide TT‑1, derived from melittin and contained only 11 amino acids, was designed, and its antitumor effect was investigated. The present study is aimed to elucidate the effects and relative mechanisms of TT‑1 on a human thyroid cancer cell line (TT) in vitro and in vivo. Cell viability assays, Annexin V/propidium iodide assays, western blotting and quantitative reverse transcription polymerase chain reaction were performed. Furthermore, a tumor‑xenograft model was established to investigate the apoptotic mechanisms of TT‑1 on TT cells. The results obtained indicated that TT‑1 was able to suppress the proliferation of TT cells and exhibited low cytotoxicity to normal thyroid cells in vitro. The apoptotic rates of TT cells were also increased following TT‑1 treatment. Additionally, TT‑1 stimulated caspase‑3, caspase‑9 and Bax, and inhibited B‑cell lymphoma 2 mRNA and protein expression. Finally, it was also demonstrated that TT‑1 is able to markedly suppress tumor growth in a TT‑bearing nude mouse model. In summary, TT‑1 may inhibit the proliferation of TT cells by inducing apoptosis in vitro and in vivo, indicating that TT‑1 may be a potential candidate for the treatment of thyroid cancer.
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1 

Yan JX, Wang KR, Chen R, Song JJ, Zhang BZ, Dang W, Zhang W and Wang R: Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie. 94:184–191. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Pellegriti G, Frasca F, Regalbuto C, Squatrito S and Vigneri R: Worldwide increasing incidence of thyroid cancer: Update on epidemiology and risk factors. J Cancer Epidemiol. 2013:9652122013. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 6:69–90. 2011. View Article : Google Scholar

4 

Matsuno A, Murakami M, Hoya K, Yamada SM, Miyamoto S, Yamada S, Son JH, Nishido H, Ide F, Nagashima H, Sugaya M, et al: Clinicopathological and molecular histochemical review of skull base metastasis from differentiated thyroid carcinoma. Acta Histochem Cytochem. 46:129–136. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Xing M, Haugen BR and Schlumberger M: Progress in molecular-based management of differentiated thyroid cancer. Lancet. 381:1058–1069. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Brown CK and Kirkwood JM: Medical management of melanoma. Surg Clin North Am. 83:283–322, viii. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Lienkamp K and Tew GN: Synthetic mimics of antimicrobial peptides-aversatile ring-opening metathesis polymerization based platform for the synthesis of selective antibacterial and cell-penetrating polymers. Chemistry. 15:11784–11800. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Chen C, Hu J, Zhang S, Zhou P, Zhao X, Xu H, Zhao X, Yaseen M and Lu JR: Molecular mechanisms of antibacterial and antitumor actions of designed surfactant-like peptides. Biomatials. 33:592–603. 2012.

9 

Brogden KA: Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nav Rev Microbiol. 3:238–250. 2005. View Article : Google Scholar

10 

Mader JS and Hoskin DW: Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin Investig Grugs. 15:933–946. 2006. View Article : Google Scholar

11 

Takahashi T, Nomura F, Yokoyama Y, Tanaka-Takiguchi Y, Homma M and Takiguchi K: Multiple membrane interactions and versatile vesicle deformations elicited by melittin. Toxins. 5:637–664. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Han SM, Kim JM, Park KK, Chang YC and Pak SC: Neuroprotective effects of melittin on hydrogen peroxide-induced apoptotic cell death in neuroblastoma SH-SY5Y cells. BMC Complement Altern Med. 14:2862014. View Article : Google Scholar : PubMed/NCBI

13 

Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrä J, Bhakdi S and Reiss K: Melittin modulates keratinocyte function through P2 Receptor-dependent ADAM Activation. J Biol Chem. 287:23678–23689. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Son DJ, Lee JW, Lee YH, Song HS, Lee CK and Hong JT: Therapeutic application of anti-arthritis, pain-releasing and anticancer effects of bee venom and its constituent compounds. Pharmacol Ther. 115:246–270. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Oršolić N: Bee venom in cancer therapy. Cancer Metastasis Rev. 31:173–194. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Raghuraman H and Chattopadhyay A: Melittin: A membrane-active peptide with diverse functions. Biosci Rep. 27:189–223. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Li SA, Lee WH and Zhang Y: Efficacy of OH-CATH30 and its analogs against drug-resistant bacteria in vitro and in mouse models. Antimicrob Agents Chemother. 56:3309–33017. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ma Q, Jiao W, Lv Y, Dong N, Zhu X and Shan A: Structure-function relationship of Val/Arg-rich peptides: Effects of net charge and pro on activity. Chem Biol Drug Des. 84:348–353. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Ozgur B and Sayar M: Role of hydrophobic/aromatic residues on the stability of double-wall β-sheet structures formed by a triblock peptide. J Phys Chem B. 121:4115–4128. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Starenki D and Park JI: Mitochondria-targeted nitroxide, mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. J Clin Endocrinol Metab. 98:1529–15240. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Wang H, Ke M, Tian Y, Wang J, Li B, Wang Y, Dou J and Zhou C: BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. Eur J Pharmaco. 707:1–10. 2013. View Article : Google Scholar

22 

Paredes-Gamero EJ, Martins MN, Cappabianco FA, Ide JS and Miranda A: Characterization of dual effects induced by antimicrobial peptides: Regulated cell death or membrane disruption. Biochim Biophys Acta. 1820:1062–91072. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Massaoka MH, Matsuo AL, Figueiredo CR, Farias CF, Girola N, Arruda DC, Scutti JA, Romoff P, Favero OA, Ferreira MJ, et al: Jacaranone induces apoptosis in melanoma cells via ROS-mediated down regulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. PLoS One. 7:e386982012. View Article : Google Scholar : PubMed/NCBI

24 

Wu C, Geng X, Wan S, Hou H, Yu F, Jia B and Wang L: Cecropin-P17, an analog of Cecropin B, inhibits human hepatocellular carcinoma cell HepG-2 proliferation via regulation of ROS, Caspase, Bax, and Bcl-2. J Pept Sci. 21:661–668. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Lu J, Yao YY, Dai QM, Ma GS, Zhang SF, Cao L, Ren LQ and Liu NF: Erythropoietin attenuates cardiac dysfunction by increasing myocardial angiogenesis and inhibiting interstitialfibrosis in diabetic rats. Cardiovasc Diabetol. 11:1052012. View Article : Google Scholar : PubMed/NCBI

26 

Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y and Hamakawa H: Prognostic Impact of Expression of Bcl-2 and Bax Genes in Circulating Immune Cells Derived from Patients with Head and Neck Carcinoma. Neoplasia. 15:305–314. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Ng CS, Wan S and Yim AP: Pulmonary ischemia-reperfusion injury: Role of apoptosis. Eur Respir J. 25:356–363. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Stjepanovic N and Capdevila J: Multikinase inhibitors in the treatment of thyroid cancer: Specific role of lenvatinib. Biologics. 8:129–139. 2014.PubMed/NCBI

30 

Leung HW, Yang WH, Lai MY, Lin CJ and Lee HZ: Inhibition of 12-lipoxygenase during baicalein-induced human lung non-small carcinoma H460 cell apoptosis. Food Chem Toxicol. 45:403–411. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Schweizer F: Cationic amphiphilic peptides with cancer selective toxicity. Eur J Pharmacol. 625:190–194. 2007. View Article : Google Scholar

32 

Sun D, Sun M, Zhu W, Wang Z, Li Y and Ma J: The anti-cancer potency and mechanism of a novel tumor-activated fused toxin, DLM. Toxins (Basel). 7:423–438. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Lockshin RA and Williams CM: Programmed cell death-I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth. J Insect Physiol. 11:123–133. 1965. View Article : Google Scholar : PubMed/NCBI

34 

Bottone MG, Santin G, Aredia F, Bernocchi G, Pellicciari C and Scovassi AI: Morphological features of organelles during apoptosis: An overview. Cells. 2:294–305. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Nuñez G, Benedict MA, Hu Y and Inohara N: Caspases: The proteases of the apoptotic pathway. Oncogene. 17:3237–3245. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Ji ES, Kim YM, Shin MS, Kim CJ, Lee KS, Kim K, Ha J and Chung YR: Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington's disease rats. J Exerc Rehabil. 11:133–139. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Tseng TH, Shen CH, Huang WS, Chen CN, Liang WH, Lin TH and Kuo HC: Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester-induced apoptosis in C6 glioma cells. J Biomed Sci. 21:612014. View Article : Google Scholar : PubMed/NCBI

38 

Vadde R, Radhakrishnan S, Reddivari L and Vanamala JK: Triphala extract suppresses proliferation and induces apoptosis in human colon cancer stem cells via suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio. Biomed Res Int. 2015:6492632015. View Article : Google Scholar : PubMed/NCBI

39 

Zhang C, Guo Z, Liu H, Shi Y and Ge S: Influence of levosimendan postconditioning on apoptosis of rat lung cells in a model of ischemia-reperfusion injury. PLoS One. 10:e01149632015. View Article : Google Scholar : PubMed/NCBI

40 

Floyd DH, Zhang Y, Dey BK, Kefas B, Breit H, Marks K, Dutta A, Herold-Mende C, Synowitz M, Glass R, et al: Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9 and Bim. PLoS One. 9:e962392014. View Article : Google Scholar : PubMed/NCBI

41 

Wyllie AH: ‘Where, O death, is thy sting?’ A brief review of apoptosis biology. Mol Neurobiol. 42:4–9. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wan L, Zhang D, Zhang J and Ren L: TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax. Oncol Lett 15: 1271-1278, 2018.
APA
Wan, L., Zhang, D., Zhang, J., & Ren, L. (2018). TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax. Oncology Letters, 15, 1271-1278. https://doi.org/10.3892/ol.2017.7366
MLA
Wan, L., Zhang, D., Zhang, J., Ren, L."TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax". Oncology Letters 15.1 (2018): 1271-1278.
Chicago
Wan, L., Zhang, D., Zhang, J., Ren, L."TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax". Oncology Letters 15, no. 1 (2018): 1271-1278. https://doi.org/10.3892/ol.2017.7366
Copy and paste a formatted citation
x
Spandidos Publications style
Wan L, Zhang D, Zhang J and Ren L: TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax. Oncol Lett 15: 1271-1278, 2018.
APA
Wan, L., Zhang, D., Zhang, J., & Ren, L. (2018). TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax. Oncology Letters, 15, 1271-1278. https://doi.org/10.3892/ol.2017.7366
MLA
Wan, L., Zhang, D., Zhang, J., Ren, L."TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax". Oncology Letters 15.1 (2018): 1271-1278.
Chicago
Wan, L., Zhang, D., Zhang, J., Ren, L."TT‑1, an analog of melittin, triggers apoptosis in human thyroid cancer TT cells via regulating caspase, Bcl‑2 and Bax". Oncology Letters 15, no. 1 (2018): 1271-1278. https://doi.org/10.3892/ol.2017.7366
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