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Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies

  • Authors:
    • Josué Rivera‑Pérez
    • María del Rocío Monter‑Vera
    • Cornelio Barrientos‑Alvarado
    • Julia D. Toscano‑Garibay
    • Teresa Cuesta‑Mejías
    • Javier Flores‑Estrada
  • View Affiliations / Copyright

    Affiliations: Direction of Research, Hospital Juárez de México, 07760 Mexico City, CDMX, Mexico, Clinical Laboratory Service, Hospital Juárez de México, 07760 Mexico City, CDMX, Mexico, Physiology Department, ESM‑IPN, 11340 Mexico City, CDMX, Mexico, Pathological Anatomy Service, Hospital Juárez de México, 07760 Mexico City, CDMX, Mexico
    Copyright: © Rivera‑Pérez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1072-1078
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    Published online on: November 8, 2017
       https://doi.org/10.3892/ol.2017.7374
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Abstract

Vascular endothelial growth factor (VEGF) and the pigment epithelium‑derived factor (PEDF) serve an important role in prostate cancer (PCa). The aim of the present study was to evaluate whether the levels of VEGF and PEDF in serum are associated with the severity of PCa, and whether they can differentiate from patients with benign prostatic hyperplasia (BPH). Two groups of patients were recruited, patients with PCa or BPH that were newly diagnosed without other comorbidities, and were compared with healthy individuals. The levels of VEGF and PEDF were measured by ELISA in serum, and by immunohistochemistry in biopsies. A correlation analysis was performed for the values in biopsies and serum, comparing the VEGF/PEDF ratio, total‑prostate‑specific antigen (t‑PSA) levels and the status of each sample as acinar Ad (Gleason score) or as benign hyperplasia. The results demonstrated that serum levels of VEGF, PEDF, and t‑PSA between PCa and BPH were similar to each other, but different to healthy individuals (P<0.05). The VEGF/PEDF ratio in serum had a significant difference between acinar Ad with Gleason score 8‑10 and BPH groups (P<0.05). The VEGF and PEDF immunostaining intensities were correlated with its circulating levels in all cases of PCa, but not in BPH. These preliminary results suggest that VEGF and PEDF levels by themselves or in combination with t‑PSA did not differentiate between malignant, and benign prostate diseases. However, there was a significant difference observed in the VEGF/PEDF ratio in serum between the groups, suggesting that it may be used as an index for diagnosis and prognosis in a personalized manner, although more studies are necessary.
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View References

1 

Brawley OW: Trends in prostate cancer in the United States. J Natl Cancer Inst Monogr. 2012:152–156. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Gomez-Guerra LS, Martinez-Fierro ML, Alcantara-Aragon V, Ortiz-Lopez R, Martinez-Villarreal RT, Morales-Rodriguez IB, Garza-Guajardo R, Ponce-Camacho MA and Rojas-Martinez A: Population based prostate cancer screening in north Mexico reveals a high prevalence of aggressive tumors in detected cases. BMC Cancer. 9:912009. View Article : Google Scholar : PubMed/NCBI

3 

Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, Minasian LM, Ford LG, Lippman SM, Crawford ED, et al: Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter. N Engl J Med. 350:2239–2246. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, Flanigan RC, DeKernion JB, Ratliff TL, Kavoussi LR, Dalkin BL, et al: Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: Results of a multicenter clinical trial of 6,630 men. J Urol. 197:S200–S207. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Liu ZQ, Fang JM, Xiao YY, Zhao Y, Cui R, Hu F and Xu Q: Prognostic role of vascular endothelial growth factor in prostate cancer: A systematic review and meta-analysis. Int J Clin Exp Med. 8:2289–2298. 2015.PubMed/NCBI

6 

Gyftopoulos K, Vourda K, Sakellaropoulos G, Perimenis P, Athanasopoulos A and Papadaki E: The angiogenic switch for vascular endothelial growth factor-A and cyclooxygenase-2 in prostate carcinoma: Correlation with microvessel density, androgen receptor content and Gleason grade. Urol Int. 87:464–469. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Nordby Y, Andersen S, Richardsen E, Ness N, Al-Saad S, Melbø-Jørgensen C, Patel HR, Dønnem T, Busund LT and Bremnes RM: Stromal expression of VEGF-A and VEGFR-2 in prostate tissue is associated with biochemical and clinical recurrence after radical prostatectomy. Prostate. 75:1682–1693. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Duque JL, Loughlin KR, Adam RM, Kantoff P, Mazzucchi E and Freeman MR: Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: Relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen. Clinics (Sao Paulo). 61:401–408. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Silva SA, Gobbo MG, Pinto-Fochi ME, Rafacho A, Taboga SR, Almeida EA, Góes RM and Ribeiro DL: Prostate hyperplasia caused by long-term obesity is characterized by high deposition of extracellular matrix and increased content of MMP-9 and VEGF. Int J Exp Pathol. 96:21–30. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Stefanou D, Batistatou A, Kamina S, Arkoumani E, Papachristou DJ and Agnantis NJ: Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in benign prostatic hyperplasia and prostate cancer. In vivo. 18:155–160. 2004.PubMed/NCBI

11 

Walsh K, Sriprasad S, Hopster D, Codd J and Mulvin D: Distribution of vascular endothelial growth factor (VEGF) in prostate disease. Prostate Cancer Prostatic Dis. 5:119–122. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Botelho F, Pina F and Lunet N: VEGF and prostatic cancer: A systematic review. Eur J Cancer Prev. 19:385–392. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Peyromaure M, Goulvestre C, Fulla Y, Grabar S, Debré B and Dinh-Xuan AT: Serum levels of vascular endothelial growth factor in patients undergoing prostate biopsy for suspicion of prostate cancer. Urology. 66:687–691. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Becerra SP and Notario V: The effects of PEDF on cancer biology: Mechanisms of action and therapeutic potential. Nat Rev Cancer. 13:258–271. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Halin S, Wikström P, Rudolfsson SH, Stattin P, Doll JA, Crawford SE and Bergh A: Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors. Cancer Res. 64:5664–5671. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Wu QJ, Gong CY, Luo ST, Zhang DM, Zhang S, Shi HS, Lu L, Yan HX, He SS, Li DD, et al: AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model. BMC Cancer. 12:1292012. View Article : Google Scholar : PubMed/NCBI

17 

Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, et al: Proapoptotic PEDF functional peptides inhibit prostate tumor growth-a mechanistic study. Biochem Pharmacol. 92:425–437. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Mirochnik Y, Aurora A, Schulze-Hoepfner FT, Deabes A, Shifrin V, Beckmann R, Polsky C and Volpert OV: Short pigment epithelial-derived factor-derived peptide inhibits angiogenesis and tumor growth. Clin Cancer Res. 15:1655–1663. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Qingyi Z, Lin Y, Junhong W, Jian S, Weizhou H, Long M, Zeyu S and Xiaojian G: Unfavorable prognostic value of human PEDF decreased in high-grade prostatic intraepithelial neoplasia: A differential proteomics approach. Cancer Invest. 27:794–801. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Byrne JC, Downes MR, O'Donoghue N, O'Keane C, O'Neill A, Fan Y, Fitzpatrick JM, Dunn M and Watson RW: 2D-DIGE as a strategy to identify serum markers for the progression of prostate cancer. J Proteome Res. 8:942–957. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Grossniklaus HE, Zhang Q, You S, McCarthy C, Heegaard S and Coupland SE: Metastatic ocular melanoma to the liver exhibits infiltrative and nodular growth patterns. Hum Pathol. 57:165–175. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Shi D, Xie F, Zhang Y, Tian Y, Chen W, Fu L, Wang J, Guo W, Kang T, Huang W and Deng W: TFAP2A regulates nasopharyngeal carcinoma growth and survival by targeting HIF-1α signaling pathway. Cancer Prev Res (Phila). 7:266–277. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Jeng KS, Sheen IS, Jeng WJ and Su JC: PEDF effectively decreases VEGF to PEDF messenger RNA ratio of the inner edge of rat hepatocellular carcinoma induced by diethyl nitrosamine-an ‘in vivo’ study. Hepatogastroenterology. 59:1484–1490. 2012.PubMed/NCBI

24 

Yang H, Xu Z, Iuvone PM and Grossniklaus HE: Angiostatin decreases cell migration and vascular endothelium growth factor (VEGF) to pigment epithelium derived factor (PEDF) RNA ratio in vitro and in a murine ocular melanoma model. Mol Vis. 12:511–517. 2006.PubMed/NCBI

25 

Bai YJ, Huang LZ, Zhou AY, Zhao M, Yu WZ and Li XX: Antiangiogenesis effects of endostatin in retinal neovascularization. J Ocul Pharmacol Ther. 29:619–626. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Regulation on Research for Health of the General Health Law. http://www.salud.gob.mx/unidades/cdi/nom/compi/rlgsmis.html

27 

Official Mexican Norm number NOM-253-SSA1-2012, for the disposal of human blood and its components for therapeutic purposes. http://www.cnts.salud.gob.mx/descargas/PROY_A_NOM_2-1.pdf

28 

Jamaspishvili T, Kral M, Khomeriki I, Student V, Kolar Z and Bouchal J: Urine markers in monitoring for prostate cancer. Prostate Cancer Prostatic Dis. 13:12–19. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Kim NH, Oh JH, Seo JA, Lee KW, Kim SG, Choi KM, Baik SH, Choi DS, Kang YS, Han SY, et al: Vascular endothelial growth factor (VEGF) and soluble VEGF receptor FLT-1 in diabetic nephropathy. Kidney Int. 67:167–177. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Shariat SF, Anwuri VA, Lamb DJ, Shah NV, Wheeler TM and Slawin KM: Association of preoperative plasma levels of vascular endothelial growth factor and soluble vascular cell adhesion molecule-1 with lymph node status and biochemical progression after radical prostatectomy. J Clin Oncol. 22:1655–1663. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Li H, Kantoff PW, Ma J, Stampfer MJ and George DJ: Prediagnostic plasma vascular endothelial growth factor levels and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 14:1557–1561. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Mao K, Badoual C, Camparo P, Delongchamps NB, Vieillefond A, Dinh-Xuan AT and Peyromaure M: The prognostic value of vascular endothelial growth factor (VEGF)-A and its receptor in clinically localized prostate cancer: A prospective evaluation in 100 patients undergoing radical prostatectomy. Can J Urol. 15:4257–4262. 2008.PubMed/NCBI

33 

Soulitzis N, Karyotis I, Delakas D and Spandidos DA: Expression analysis of peptide growth factors VEGF FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia. Int J Oncol. 29:305–314. 2006.PubMed/NCBI

34 

Lekas A, Lazaris AC, Deliveliotis C, Chrisofos M, Zoubouli C, Lapas D, Papathomas T, Fokitis I and Nakopoulou L: The expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and angiogenesis markers in hyperplastic and malignant prostate tissue. Anticancer Res. 26:2989–2993. 2006.PubMed/NCBI

35 

Shih SJ, Dall'Era MA, Westphal JR, Yang J, Sweep CG, Gandour-Edwards R and Evans CP: Elements regulating angiogenesis and correlative microvessel density in benign hyperplastic and malignant prostate tissue. Prostate Cancer Prostatic Dis. 6:131–137. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Voss M, Trojan L, Steidler A, Weiss C, Grobholz R, Alken P and Michel MS: Serum vascular endothelial growth factor C level in patients with prostate cancer and benign prostatic hyperplasia. Anal Quant Cytol Histol. 30:199–202. 2008.PubMed/NCBI

37 

Matsui T, Ojima A, Higashimoto Y, Taira J, Fukami K and Yamagishi SI: Pigment epithelium-derived factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate cancer cells. Oncol Lett. 10:2644–2648. 2015.PubMed/NCBI

38 

Nelius T, Martinez-Marin D, Hirsch J, Miller B, Rinard K, Lopez J, de Riese W and Filleur S: Pigment epithelium-derived factor expression prolongs survival and enhances the cytotoxicity of low-dose chemotherapy in castration-refractory prostate cancer. Cell Death Dis. 5:e12102014. View Article : Google Scholar : PubMed/NCBI

39 

Hirsch J, Johnson CL, Nelius T, Kennedy R, Riese WD and Filleur S: PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor/phospholipase A2 and regulation of NFκB and PPARγ. Cytokine. 55:202–210. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Nelius T, Samathanam C, Martinez-Marin D, Gaines N, Stevens J, Hickson J, de Riese W and Filleur S: Positive correlation between PEDF expression levels and macrophage density in the human prostate. Prostate. 73:549–561. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Ide H, Yamagishi S, Lu Y, Sakamaki K, Nakajima A, Horiuchi A, Kitamura K, Hisasue S, Muto S, Yamaguchi R and Horie S: Circulating pigment epithelium-derived factor (PEDF) is associated with pathological grade of prostate cancer. Anticancer Res. 35:1703–1708. 2015.PubMed/NCBI

42 

Doll JA, Stellmach VM, Bouck NP, Bergh AR, Lee C, Abramson LP, Cornwell ML, Pins MR, Borensztajn J and Crawford SE: Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med. 9:774–780. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Carnagarin R, Dharmarajan AM and Dass CR: PEDF-induced alteration of metabolism leading to insulin resistance. Mol Cell Endocrinol. 401:98–104. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Cai J, Chen Z, Ruan Q, Han S, Liu L, Qi X, Boye SL, Hauswirth WW, Grant MB and Boulton ME: γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. J Biol Chem. 286:42514–42523. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Pollina EA, Legesse-Miller A, Haley EM, Goodpaster T, Randolph-Habecker J and Coller HA: Regulating the angiogenic balance in tissues. Cell Cycle. 7:2056–2070. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Volpert OV, Zaichuk T, Zhou W, Reiher F, Ferguson TA, Stuart PM, Amin M and Bouck NP: Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med. 8:349–357. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Rivera‑Pérez J, Monter‑Vera Md, Barrientos‑Alvarado C, Toscano‑Garibay JD, Cuesta‑Mejías T and Flores‑Estrada J: Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies. Oncol Lett 15: 1072-1078, 2018.
APA
Rivera‑Pérez, J., Monter‑Vera, M.d., Barrientos‑Alvarado, C., Toscano‑Garibay, J.D., Cuesta‑Mejías, T., & Flores‑Estrada, J. (2018). Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies. Oncology Letters, 15, 1072-1078. https://doi.org/10.3892/ol.2017.7374
MLA
Rivera‑Pérez, J., Monter‑Vera, M. d., Barrientos‑Alvarado, C., Toscano‑Garibay, J. D., Cuesta‑Mejías, T., Flores‑Estrada, J."Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies". Oncology Letters 15.1 (2018): 1072-1078.
Chicago
Rivera‑Pérez, J., Monter‑Vera, M. d., Barrientos‑Alvarado, C., Toscano‑Garibay, J. D., Cuesta‑Mejías, T., Flores‑Estrada, J."Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies". Oncology Letters 15, no. 1 (2018): 1072-1078. https://doi.org/10.3892/ol.2017.7374
Copy and paste a formatted citation
x
Spandidos Publications style
Rivera‑Pérez J, Monter‑Vera Md, Barrientos‑Alvarado C, Toscano‑Garibay JD, Cuesta‑Mejías T and Flores‑Estrada J: Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies. Oncol Lett 15: 1072-1078, 2018.
APA
Rivera‑Pérez, J., Monter‑Vera, M.d., Barrientos‑Alvarado, C., Toscano‑Garibay, J.D., Cuesta‑Mejías, T., & Flores‑Estrada, J. (2018). Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies. Oncology Letters, 15, 1072-1078. https://doi.org/10.3892/ol.2017.7374
MLA
Rivera‑Pérez, J., Monter‑Vera, M. d., Barrientos‑Alvarado, C., Toscano‑Garibay, J. D., Cuesta‑Mejías, T., Flores‑Estrada, J."Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies". Oncology Letters 15.1 (2018): 1072-1078.
Chicago
Rivera‑Pérez, J., Monter‑Vera, M. d., Barrientos‑Alvarado, C., Toscano‑Garibay, J. D., Cuesta‑Mejías, T., Flores‑Estrada, J."Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies". Oncology Letters 15, no. 1 (2018): 1072-1078. https://doi.org/10.3892/ol.2017.7374
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