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Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI

  • Authors:
    • Hio Teng Cheong
    • Fei Xu
    • Chi Tung Choy
    • Connie Wun Chun Hui
    • Tony Shu Kam Mok
    • Chi Hang Wong
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, P.R. China, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510000, P.R. China
    Copyright: © Cheong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 901-907
    |
    Published online on: November 9, 2017
       https://doi.org/10.3892/ol.2017.7377
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Abstract

Lung cancer has the highest incidence and mortality rate worldwide among all malignancy‑associated mortalities, of which non‑small cell lung cancer accounts for 80% of all cases. Resistance against epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) develops following 8‑12 months of disease progression, and is a critical issue. HCC827 cell lines with resistance to EGFR‑TKIs were successfully screened. The half maximal inhibitory concentration values were 1,000‑fold higher than the values for the parental HCC827 cell line, thereby demonstrating cross‑resistance against the same family of TKIs. The expression of B‑cell lymphoma 2 (Bcl2) was markedly increased in the resistant clones, as well as in the patient biopsies. The phosphatase and tensin homolog phosphoinositide 3‑kinase signaling axis is a potential mechanism for acquiring resistance, and therefore targeting Bcl2 may be a useful strategy for further investigations.
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Copy and paste a formatted citation
Spandidos Publications style
Cheong H, Xu F, Choy C, Hui C, Mok T and Wong C: Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI. Oncol Lett 15: 901-907, 2018.
APA
Cheong, H., Xu, F., Choy, C., Hui, C., Mok, T., & Wong, C. (2018). Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI. Oncology Letters, 15, 901-907. https://doi.org/10.3892/ol.2017.7377
MLA
Cheong, H., Xu, F., Choy, C., Hui, C., Mok, T., Wong, C."Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI". Oncology Letters 15.1 (2018): 901-907.
Chicago
Cheong, H., Xu, F., Choy, C., Hui, C., Mok, T., Wong, C."Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI". Oncology Letters 15, no. 1 (2018): 901-907. https://doi.org/10.3892/ol.2017.7377
Copy and paste a formatted citation
x
Spandidos Publications style
Cheong H, Xu F, Choy C, Hui C, Mok T and Wong C: Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI. Oncol Lett 15: 901-907, 2018.
APA
Cheong, H., Xu, F., Choy, C., Hui, C., Mok, T., & Wong, C. (2018). Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI. Oncology Letters, 15, 901-907. https://doi.org/10.3892/ol.2017.7377
MLA
Cheong, H., Xu, F., Choy, C., Hui, C., Mok, T., Wong, C."Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI". Oncology Letters 15.1 (2018): 901-907.
Chicago
Cheong, H., Xu, F., Choy, C., Hui, C., Mok, T., Wong, C."Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKI". Oncology Letters 15, no. 1 (2018): 901-907. https://doi.org/10.3892/ol.2017.7377
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