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Article

MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma

  • Authors:
    • Peng Du
    • Xinping Luan
    • Yiwei Liao
    • Yiti Mu
    • Yang Yuan
    • Jingxuan Xu
    • Jingjing Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, the Second Affiliated Hospital, Xinjiang Medical University, Ürümqi, Uygur Autonomous Region 830063, P.R. China, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 1307-1312
    |
    Published online on: November 10, 2017
       https://doi.org/10.3892/ol.2017.7390
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Abstract

Malignant glioma is an aggressive type of cancer. Increasing evidence has suggested that microRNAs (miRs) regulate gene expression post‑transcriptionally to affect cancer development and progression. Aberrant expression of miR‑509‑3p has been reported in cancer studies. However, the expression and mechanism of its function in glioma remains unclear. The present study demonstrated that miR‑509‑3p was downregulated in glioma tissue samples relative to non‑tumor tissues, and that low miR‑509‑3p expression was associated with a reduced overall survival time. Functional studies revealed that the overexpression of miR‑509‑3p inhibited cell proliferation, induced apoptosis and suppressed cell migration and invasion via negatively regulating the expression of X‑linked inhibitor of apoptosis. The data therefore suggested that miR‑509‑3p serves an important role in the development and progression of glioma, implicating its possible application in clinical practice as a biomarker and a potential novel therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Du P, Luan X, Liao Y, Mu Y, Yuan Y, Xu J and Zhang J: MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma. Oncol Lett 15: 1307-1312, 2018.
APA
Du, P., Luan, X., Liao, Y., Mu, Y., Yuan, Y., Xu, J., & Zhang, J. (2018). MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma. Oncology Letters, 15, 1307-1312. https://doi.org/10.3892/ol.2017.7390
MLA
Du, P., Luan, X., Liao, Y., Mu, Y., Yuan, Y., Xu, J., Zhang, J."MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma". Oncology Letters 15.1 (2018): 1307-1312.
Chicago
Du, P., Luan, X., Liao, Y., Mu, Y., Yuan, Y., Xu, J., Zhang, J."MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma". Oncology Letters 15, no. 1 (2018): 1307-1312. https://doi.org/10.3892/ol.2017.7390
Copy and paste a formatted citation
x
Spandidos Publications style
Du P, Luan X, Liao Y, Mu Y, Yuan Y, Xu J and Zhang J: MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma. Oncol Lett 15: 1307-1312, 2018.
APA
Du, P., Luan, X., Liao, Y., Mu, Y., Yuan, Y., Xu, J., & Zhang, J. (2018). MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma. Oncology Letters, 15, 1307-1312. https://doi.org/10.3892/ol.2017.7390
MLA
Du, P., Luan, X., Liao, Y., Mu, Y., Yuan, Y., Xu, J., Zhang, J."MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma". Oncology Letters 15.1 (2018): 1307-1312.
Chicago
Du, P., Luan, X., Liao, Y., Mu, Y., Yuan, Y., Xu, J., Zhang, J."MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma". Oncology Letters 15, no. 1 (2018): 1307-1312. https://doi.org/10.3892/ol.2017.7390
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