MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma

Du,Peng; Luan,Xinping; Liao,Yiwei; Mu,Yiti; Yuan,Yang; Xu,Jingxuan; Zhang,Jingjing

doi:10.3892/ol.2017.7390

MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma

Authors:
- Peng Du
- Xinping Luan
- Yiwei Liao
- Yiti Mu
- Yang Yuan
- Jingxuan Xu
- Jingjing Zhang
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Affiliations: Department of Neurosurgery, the Second Affiliated Hospital, Xinjiang Medical University, Ürümqi, Uygur Autonomous Region 830063, P.R. China, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: November 10, 2017 https://doi.org/10.3892/ol.2017.7390
Pages: 1307-1312

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Abstract

Malignant glioma is an aggressive type of cancer. Increasing evidence has suggested that microRNAs (miRs) regulate gene expression post‑transcriptionally to affect cancer development and progression. Aberrant expression of miR‑509‑3p has been reported in cancer studies. However, the expression and mechanism of its function in glioma remains unclear. The present study demonstrated that miR‑509‑3p was downregulated in glioma tissue samples relative to non‑tumor tissues, and that low miR‑509‑3p expression was associated with a reduced overall survival time. Functional studies revealed that the overexpression of miR‑509‑3p inhibited cell proliferation, induced apoptosis and suppressed cell migration and invasion via negatively regulating the expression of X‑linked inhibitor of apoptosis. The data therefore suggested that miR‑509‑3p serves an important role in the development and progression of glioma, implicating its possible application in clinical practice as a biomarker and a potential novel therapeutic target.

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