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Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer

  • Authors:
    • Feng Cai
    • Yingying Miao
    • Chenyang Liu
    • Ting Wu
    • Simei Shen
    • Xin Su
    • Yi Shi
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 731-740
    |
    Published online on: November 14, 2017
       https://doi.org/10.3892/ol.2017.7400
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Abstract

Disordered tumor cell metabolism is involved in the process of tumorigenesis. Proline metabolism is of critical importance for tumor cells, and pyrroline‑5‑carboxylate reductase 1 (PYCR1), a key proline biosynthesis enzyme, has been reported to be overexpressed in prostate cancer and to promote tumor cell growth in breast cancer. The present study investigated the relationship between PYCR1 and non‑small cell lung cancer (NSCLC). The results revealed that PYCR1 was overexpressed in NSCLC tumor tissues compared with adjacent normal tissues. High PYCR1 expression was associated with poor prognosis in patients with NSCLC. Following knockdown of PYCR1 by small interfering RNA, cell proliferation was revealed to be significantly inhibited and the cell cycle was arrested, while apoptosis was increased in SPC‑A1 and H1703 NSCLC cells. Furthermore, the silencing of PYCR1 resulted in the downregulation of expression of the cell cycle regulator cyclin D1, the regulator of the mitochondrial apoptotic pathway B‑cell lymphoma‑2, and B‑cell lymphoma‑extra large. The results of the present study indicated the involvement of PYCR1 in the proliferation and apoptosis of NSCLC. Therefore, PYCR1 may be a novel therapeutic target for inhibiting cell proliferation in lung cancer.
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1 

GBD 2013 Mortality and Causes of Death Collaborators: Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 385:117–171. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Johnson C, Warmoes MO, Shen X and Locasale JW: Epigenetics and cancer metabolism. Cancer Lett. 356:309–314. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI

6 

Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer. 11:85–95. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Phang JM and Liu W: Proline metabolism and cancer. Front Biosci (Landmark Ed). 17:1835–1845. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Phang JM, Liu W, Hancock CN and Fischer JW: Proline metabolism and cancer: Emerging links to glutamine and collagen. Curr Opin Clin Nutr Metab Care. 18:71–77. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Maxwell SA and Davis GE: Differential gene expression in p53-mediated apoptosis-resistant vs. Apoptosis-sensitive tumor cell lines. Proc Natl Acad Sci USA. 97:pp. 13009–13014. 2000; View Article : Google Scholar : PubMed/NCBI

10 

Maxwell SA and Rivera A: Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas. J Biol Chem. 278:9784–9789. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Liu W and Phang JM: Proline dehydrogenase (oxidase) in cancer. Biofactors. 38:398–406. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Guernsey DL, Jiang H, Evans SC, Ferguson M, Matsuoka M, Nightingale M, Rideout AL, Provost S, Bedard K, Orr A, et al: Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2. Am J Hum Genet. 85:120–129. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, et al: Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476:346–350. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Fang Y, Fu D, Tang W, Cai Y, Ma D, Wang H, Xue R, Liu T, Huang X, Dong L, et al: Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19. Biochim Biophys Acta. 1833:559–572. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Jariwala U, Prescott J, Jia L, Barski A, Pregizer S, Cogan JP, Arasheben A, Tilley WD, Scher HI, Gerald WL, et al: Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer. 6:392007. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Musgrove EA: Cyclins: Roles in mitogenic signaling and oncogenic transformation. Growth Factors. 24:13–19. 2006. View Article : Google Scholar : PubMed/NCBI

19 

De Ingeniis J, Kazanov MD, Shatalin K, Gelfand MS, Osterman AL and Sorci L: Glutamine versus ammonia utilization in the NAD synthetase family. PLoS One. 7:e391152012. View Article : Google Scholar : PubMed/NCBI

20 

Mohamed A, Deng X, Khuri FR and Owonikoko TK: Altered glutamine metabolism and therapeutic opportunities for lung cancer. Clin Lung Cancer. 15:7–15. 2014. View Article : Google Scholar : PubMed/NCBI

21 

De Ingeniis J, Ratnikov B, Richardson AD, Scott DA, Aza-Blanc P, De SK, Kazanov M, Pellecchia M, Ronai Z, Osterman AL and Smith JW: Functional specialization in proline biosynthesis of melanoma. PLoS One. 7:e451902012. View Article : Google Scholar : PubMed/NCBI

22 

Ernst T, Hergenhahn M, Kenzelmann M, Cohen CD, Bonrouhi M, Weninger A, Klären R, Gröne EF, Wiesel M, Güdemann C, et al: Decrease and gain of gene expression are equally discriminatory markers for prostate carcinoma: A gene expression analysis on total and microdissected prostate tissue. Am J Pathol. 160:2169–2180. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Liu W, Hancock CN, Fischer JW, Harman M and Phang JM: Proline biosynthesis augments tumor cell growth and aerobic glycolysis: Involvement of pyridine nucleotides. Sci Rep. 5:172062015. View Article : Google Scholar : PubMed/NCBI

24 

Bretones G, Delgado MD and Leon J: Myc and cell cycle control. Biochim Biophys Acta. 1849:506–516. 2015. View Article : Google Scholar : PubMed/NCBI

25 

McMahon SB: MYC and the control of apoptosis. Cold Spring Harb Perspect Med. 4:a0144072014. View Article : Google Scholar : PubMed/NCBI

26 

Morrish F and Hockenbery D: MYC and mitochondrial biogenesis. Cold Spring Harb Perspect Med. 4:pii: a0142252014. View Article : Google Scholar

27 

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW and Phang JM: Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA. 109:pp. 8983–8988. 2012; View Article : Google Scholar : PubMed/NCBI

28 

Kato JY, Matsuoka M, Strom DK and Sherr CJ: Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol. 14:2713–2721. 1994. View Article : Google Scholar : PubMed/NCBI

29 

Han EK, Ng SC, Arber N, Begemann M and Weinstein IB: Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis. Apoptosis. 4:213–219. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Gautschi O, Ratschiller D, Gugger M, Betticher DC and Heighway J: Cyclin D1 in non-small cell lung cancer: A key driver of malignant transformation. Lung Cancer. 55:1–14. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Biliran H Jr, Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bollig A, Sarkar FH and Liao JD: Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin Cancer Res. 11:6075–6086. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Adams JM and Cory S: The Bcl-2 protein family: Arbiters of cell survival. Science. 281:1322–1326. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, et al: High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer. 10:1862010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cai F, Miao Y, Liu C, Wu T, Shen S, Su X and Shi Y: Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer. Oncol Lett 15: 731-740, 2018.
APA
Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X., & Shi, Y. (2018). Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer. Oncology Letters, 15, 731-740. https://doi.org/10.3892/ol.2017.7400
MLA
Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X., Shi, Y."Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer". Oncology Letters 15.1 (2018): 731-740.
Chicago
Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X., Shi, Y."Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer". Oncology Letters 15, no. 1 (2018): 731-740. https://doi.org/10.3892/ol.2017.7400
Copy and paste a formatted citation
x
Spandidos Publications style
Cai F, Miao Y, Liu C, Wu T, Shen S, Su X and Shi Y: Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer. Oncol Lett 15: 731-740, 2018.
APA
Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X., & Shi, Y. (2018). Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer. Oncology Letters, 15, 731-740. https://doi.org/10.3892/ol.2017.7400
MLA
Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X., Shi, Y."Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer". Oncology Letters 15.1 (2018): 731-740.
Chicago
Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X., Shi, Y."Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer". Oncology Letters 15, no. 1 (2018): 731-740. https://doi.org/10.3892/ol.2017.7400
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