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Article

Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis

  • Authors:
    • Rui‑Hua Fan
    • Jia‑Ni Guo
    • Wei Yan
    • Ming‑De Huang
    • Chang‑Li Zhu
    • Yong‑Mei Yin
    • Xiao‑Fei Chen
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 6497-6502
    |
    Published online on: February 20, 2018
       https://doi.org/10.3892/ol.2018.8087
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Abstract

Esophageal cancer (ESCC) is one of the most common causes of cancer-associated mortality in China. The present investigation reveals that non‑coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), exert a significant effect on the initiation, development and metastasis of malignant tumors, including ESCC. However, to the best of our knowledge, the function of non‑protein‑coding genes that host small nucleolar RNAs has not been investigated in cancer, particularly in ESCC. The expression of small nucleolar host gene 6 (SNHG6) in 70 ESCC tissues and paired adjacent tissues was measured by reverse transcription quantitative polymerase chain reaction. Analysis demonstrated that SNHG6 expression was significantly increased in ESCC tissues, and associated with tumor size (P=0.040) and Tumor‑Node‑Metastasis stage (P<0.01). Knockdown of SNHG6 may inhibit proliferative and colony‑forming abilities, and induce apoptosis, in ESCC cells. To the best of our knowledge, the data from the present study indicated for the first time that SNHG6 was upregulated in ESCC tissues and cell lines. This novel lncRNA may exert a marked effect on the generation and progression of ESCC, potentially providing a novel perspective on ESCC diagnosis and management.
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Copy and paste a formatted citation
Spandidos Publications style
Fan RH, Guo JN, Yan W, Huang MD, Zhu CL, Yin YM and Chen XF: Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis. Oncol Lett 15: 6497-6502, 2018.
APA
Fan, R., Guo, J., Yan, W., Huang, M., Zhu, C., Yin, Y., & Chen, X. (2018). Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis. Oncology Letters, 15, 6497-6502. https://doi.org/10.3892/ol.2018.8087
MLA
Fan, R., Guo, J., Yan, W., Huang, M., Zhu, C., Yin, Y., Chen, X."Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis". Oncology Letters 15.5 (2018): 6497-6502.
Chicago
Fan, R., Guo, J., Yan, W., Huang, M., Zhu, C., Yin, Y., Chen, X."Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis". Oncology Letters 15, no. 5 (2018): 6497-6502. https://doi.org/10.3892/ol.2018.8087
Copy and paste a formatted citation
x
Spandidos Publications style
Fan RH, Guo JN, Yan W, Huang MD, Zhu CL, Yin YM and Chen XF: Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis. Oncol Lett 15: 6497-6502, 2018.
APA
Fan, R., Guo, J., Yan, W., Huang, M., Zhu, C., Yin, Y., & Chen, X. (2018). Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis. Oncology Letters, 15, 6497-6502. https://doi.org/10.3892/ol.2018.8087
MLA
Fan, R., Guo, J., Yan, W., Huang, M., Zhu, C., Yin, Y., Chen, X."Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis". Oncology Letters 15.5 (2018): 6497-6502.
Chicago
Fan, R., Guo, J., Yan, W., Huang, M., Zhu, C., Yin, Y., Chen, X."Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis". Oncology Letters 15, no. 5 (2018): 6497-6502. https://doi.org/10.3892/ol.2018.8087
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