Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis

Fan,Rui‑Hua; Guo,Jia‑Ni; Yan,Wei; Huang,Ming‑De; Zhu,Chang‑Li; Yin,Yong‑Mei; Chen,Xiao‑Fei

doi:10.3892/ol.2018.8087

Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis

Authors:
- Rui‑Hua Fan
- Jia‑Ni Guo
- Wei Yan
- Ming‑De Huang
- Chang‑Li Zhu
- Yong‑Mei Yin
- Xiao‑Fei Chen
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Affiliations: Department of Medical Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China
Published online on: February 20, 2018 https://doi.org/10.3892/ol.2018.8087
Pages: 6497-6502

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Abstract

Esophageal cancer (ESCC) is one of the most common causes of cancer-associated mortality in China. The present investigation reveals that non‑coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), exert a significant effect on the initiation, development and metastasis of malignant tumors, including ESCC. However, to the best of our knowledge, the function of non‑protein‑coding genes that host small nucleolar RNAs has not been investigated in cancer, particularly in ESCC. The expression of small nucleolar host gene 6 (SNHG6) in 70 ESCC tissues and paired adjacent tissues was measured by reverse transcription quantitative polymerase chain reaction. Analysis demonstrated that SNHG6 expression was significantly increased in ESCC tissues, and associated with tumor size (P=0.040) and Tumor‑Node‑Metastasis stage (P<0.01). Knockdown of SNHG6 may inhibit proliferative and colony‑forming abilities, and induce apoptosis, in ESCC cells. To the best of our knowledge, the data from the present study indicated for the first time that SNHG6 was upregulated in ESCC tissues and cell lines. This novel lncRNA may exert a marked effect on the generation and progression of ESCC, potentially providing a novel perspective on ESCC diagnosis and management.

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