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Article

A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression

  • Authors:
    • Satoru Monzen
    • Mitsuru Chiba
    • Tatsuya Ueno
    • Yuki Morino
    • Kenji Terada
    • Hiroki Yamaya
    • Yoichiro Hosokawa
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036‑8564, Japan, Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036‑8564, Japan
  • Pages: 6709-6714
    |
    Published online on: February 21, 2018
       https://doi.org/10.3892/ol.2018.8099
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Abstract

In the present study, the cell viability and cluster of differentiation (CD)38 mRNA expression were evaluated in radioresistant (Res)-HL60 acute promyelocytic leukemia (APL) cells. Cell viability in Res‑HL60 cells was higher compared with wild‑type HL60 cells, but did not differ between high and mid/low CD38 antigen expression groups in Res‑HL60 cells. A higher expression of CD38 mRNA in Res‑HL60 cells was observed, particularly in the CD38high cell subpopulation. Furthermore, the expression of CD38 mRNA was upregulated following exposure to X‑irradiation. In contrast, the characteristic expression of CD45 and CCAAT/enhancer‑binding protein α mRNA were not altered. These results suggest that the accumulation of CD38 protein in radioresistant APL cells, resulting from the constant expression of CD38 mRNA induced by X‑irradiation, is a characteristic response of the radioresistant‑surviving fraction; however, the accumulation of CD38 did not influence the extent of radioresistant behavior.
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Copy and paste a formatted citation
Spandidos Publications style
Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H and Hosokawa Y: A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression. Oncol Lett 15: 6709-6714, 2018.
APA
Monzen, S., Chiba, M., Ueno, T., Morino, Y., Terada, K., Yamaya, H., & Hosokawa, Y. (2018). A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression. Oncology Letters, 15, 6709-6714. https://doi.org/10.3892/ol.2018.8099
MLA
Monzen, S., Chiba, M., Ueno, T., Morino, Y., Terada, K., Yamaya, H., Hosokawa, Y."A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression". Oncology Letters 15.5 (2018): 6709-6714.
Chicago
Monzen, S., Chiba, M., Ueno, T., Morino, Y., Terada, K., Yamaya, H., Hosokawa, Y."A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression". Oncology Letters 15, no. 5 (2018): 6709-6714. https://doi.org/10.3892/ol.2018.8099
Copy and paste a formatted citation
x
Spandidos Publications style
Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H and Hosokawa Y: A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression. Oncol Lett 15: 6709-6714, 2018.
APA
Monzen, S., Chiba, M., Ueno, T., Morino, Y., Terada, K., Yamaya, H., & Hosokawa, Y. (2018). A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression. Oncology Letters, 15, 6709-6714. https://doi.org/10.3892/ol.2018.8099
MLA
Monzen, S., Chiba, M., Ueno, T., Morino, Y., Terada, K., Yamaya, H., Hosokawa, Y."A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression". Oncology Letters 15.5 (2018): 6709-6714.
Chicago
Monzen, S., Chiba, M., Ueno, T., Morino, Y., Terada, K., Yamaya, H., Hosokawa, Y."A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression". Oncology Letters 15, no. 5 (2018): 6709-6714. https://doi.org/10.3892/ol.2018.8099
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