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Article

Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells

  • Authors:
    • Macario Martínez-Castillo
    • Nicolas Villegas-Sepúlveda
    • Marco   A. Meraz-Rios
    • Araceli Hernández-Zavala
    • Jaime Berumen
    • Mathew  A. Coleman
    • Lorena Orozco
    • Emilio J. Cordova
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biomedicine, Center of Studies and Advance Research, 07360 Mexico City, Mexico, Section of Research and Postgraduate, Superior School of Medicine, National Institute Polytechnique, Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomás, 11350 Mexico City, Mexico, Faculty of Medicine, National Autonomous University of Mexico (UNAM), AP, 04510 Mexico City, Mexico, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA, National Institute of Genomic Medicine, Clinic Research, 14610 Mexico City, Mexico
  • Pages: 6777-6783
    |
    Published online on: February 23, 2018
       https://doi.org/10.3892/ol.2018.8112
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Abstract

Curcumin is a phytochemical with potent anti-neoplastic properties. The antitumoral effects of curcumin in cells derived from chronic or acute myeloid leukemia have been already described. However, a comparative study of the cytostatic and cytotoxic effects of curcumin on chronic and acute myeloid leukemia cells has not yet been performed. In the present study, the cellular effects of curcumin on cell lines derived from chronic or acute myeloid leukemia were examined. Dose and time-response assays were performed with curcumin on HL-60 and K562 cells. Cell viability was evaluated with trypan blue exclusion test and cell death by flow cytometry using a fluorescent molecular probe. A cell cycle profile was analyzed, and protein markers of cell cycle progression and cell death were investigated. In the present study, the K562 cells showed a higher sensitivity to the cytostatic and cytotoxic effects of curcumin compared with HL-60. In addition, curcumin induced G1 phase arrest in HL-60 cells and G2/M phase arrest in K562 cells. Furthermore, curcumin-related cell death in HL-60 was associated with the processed forms of caspases-9 and -3 proteins, whereas in K562 cells, both the processed and the unprocessed forms were present. Accordingly, activity of these caspases was significantly higher in HL-60 cells compared with that in K562. In conclusion, curcumin elicits different cellular mechanisms in chronic or acute myeloid leukemia cells and the powerful antitumoral effect was more potent in K562 compared with HL-60 cells.
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1 

Shakibaei M, Buhrmann C, Kraehe P, Shayan P, Lueders C and Goel A: Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. PLoS One. 9:e853972014. View Article : Google Scholar : PubMed/NCBI

2 

Fan Z, Duan X, Cai H, Wang L, Li M, Qu J, Li W, Wang Y and Wang J: Curcumin inhibits the invasion of lung cancer cells by modulating the PKCα/Nox-2/ROS/ATF-2/MMP-9 signaling pathway. Oncol Rep. 34:691–698. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Ferreira LC, Arbab AS, Jardim-Perassi BV, Borin TF, Varma NR, Iskander AS, Shankar A, Ali MM and Zuccari DA: Effect of curcumin on pro-angiogenic factors in the xenograft model of breast cancer. Anticancer Agents Med Chem. 15:1285–1296. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Huang AC, Lin SY, Su CC, Lin SS, Ho CC, Hsia TC, Chiu TH, Yu CS, Ip SW, Lin TP and Chung JG: Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo. In Vivo. 22:781–785. 2008.PubMed/NCBI

5 

Carroll RE, Benya RV, Turgeon DK, Vareed S, Neuman M, Rodriguez L, Kakarala M, Carpenter PM, McLaren C, Meyskens FL Jr and Brenner DE: phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res. 4:354–364. 2011. View Article : Google Scholar

6 

Epelbaum R, Schaffer M, Vizel B, Badmaev V and Bar-Sela G: Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer. 62:1137–1141. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Sha J, Li J, Wang W, Pan L, Cheng J, Li L, Zhao H and Lin W: Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling. Biomed Pharmacother. 84:177–184. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Sun SH, Huang HC, Huang C and Lin JK: Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin. Eur J Pharmacol. 690:22–30. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Cheng C, Jiao JT, Qian Y, Guo XY, Huang J, Dai MC, Zhang L, Ding XP, Zong D and Shao JF: Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells. Mol Med Rep. 13:3763–3770. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Lu JJ, Cai YJ and Ding J: Curcumin induces DNA damage and caffeine insensitive cell cycle arrest in colorectal carcinoma HCT116 cells. Mol Cell Biochem. 354:247–252. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Guo H, Xu YM, Ye ZQ, Yu JH and Hu XY: Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 68:431–434. 2013.PubMed/NCBI

12 

Cao A, Li Q, Yin P, Dong Y, Shi H, Wang L, Ji G, Xie J and Wu D: Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 18:1391–1402. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Yao Q, Lin M, Wang Y, Lai Y, Hu J, Fu T, Wang L, Lin S, Chen L and Guo Y: Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways. Int J Mol Med. 36:1118–1126. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Subramaniam D, Ramalingam S, Linehan DC, Dieckgraefe BK, Postier RG, Houchen CW, Jensen RA and Anant S: RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells. PLoS One. 6:e169582011. View Article : Google Scholar : PubMed/NCBI

15 

O'Sullivan-Coyne G, O'Sullivan GC, O'Donovan TR, Piwocka K and McKenna SL: Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br J Cancer. 101:1585–1595. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zhao G, Han X, Zheng S, Li Z, Sha Y, Ni J, Sun Z, Qiao S and Song Z: Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells. Oncol Rep. 35:1065–1074. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Tork OM, Khaleel EF and Abdelmaqsoud OM: Altered cell to cell communication, autophagy and mitochondrial dysfunction in a model of hepatocellular carcinoma: Potential protective effects of curcumin and stem cell therapy. Asian Pac J Cancer Prev. 16:8271–8279. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Tan TW, Tsai HR, Lu HF, Lin HL, Tsou MF, Lin YT, Tsai HY, Chen YF and Chung JG: Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation. Anticancer Res. 26:4361–4371. 2006.PubMed/NCBI

19 

Sarkar R, Mukherjee A, Mukherjee S, Biswas R, Biswas J and Roy M: Curcumin augments the efficacy of antitumor drugs used in leukemia by modulation of heat shock proteins via HDAC6. J Environ Pathol Toxicol Oncol. 33:247–263. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhang JR, Lu F, Lu T, Dong WH, Li P, Liu N, Ma DX and Ji CY: Inactivation of FoxM1 transcription factor contributes to curcumin-induced inhibition of survival, angiogenesis, and chemosensitivity in acute myeloid leukemia cells. J Mol Med. 92:1319–1330. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Liu Y, Chang RL, Cui XX, Newmark HL and Conney AH: Synergistic effects of curcumin on all-trans retinoic acid- and 1 alpha,25-dihydroxyvitamin D3-induced differentiation in human promyelocytic leukemia HL-60 cells. Oncol Res. 9:19–29. 1997.PubMed/NCBI

22 

Chen J, Wang G, Wang L, Kang J and Wang J: Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells. Eur J Pharm Sci. 41:210–218. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Duvoix A, Morceau F, Schnekenburger M, Delhalle S, Galteau MM, Dicato M and Diederich M: Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat. Ann N Y Acad Sci. 1010:389–392. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK and Roy M: Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat Res. 596:81–90. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Jia YL, Li J, Qin ZH and Liang ZQ: Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells. J Asian Nat Prod Res. 11:918–928. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Jiang AJ, Jiang G, Li LT and Zheng JN: Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Mol Biol Rep. 42:267–275. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Blakemore LM, Boes C, Cordell R and Manson MM: Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage. Carcinogenesis. 34:351–360. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Mathur A, Abd Elmageed ZY, Liu X, Kostochka ML, Zhang H, Abdel-Mageed AB and Mondal D: Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells. PLoS One. 9:e1031092014. View Article : Google Scholar : PubMed/NCBI

29 

Zeng Y, Weng G, Fan J, Li Z, Wu J, Li Y, Zheng R, Xia P and Guo K: Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 36:1233–1242. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Chen J, Wanming D, Zhang D, Liu Q and Kang J: Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells. Pharmazie. 60:57–61. 2005.PubMed/NCBI

31 

Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, et al: Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS One. 8:e559342013. View Article : Google Scholar : PubMed/NCBI

32 

Rao J, Xu DR, Zheng FM, Long ZJ, Huang SS, Wu X, Zhou WH, Huang RW and Liu Q: Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells. J Transl Med. 9:712011. View Article : Google Scholar : PubMed/NCBI

33 

Wolanin K, Magalska A, Mosieniak G, Klinger R, McKenna S, Vejda S, Sikora E and Piwocka K: Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells. Mol Cancer Res. 4:457–469. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Sánchez Y, Simón GP, Calviño E, de Blas E and Aller P: Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. J Pharmacol Exp Ther. 335:114–123. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Martinez-Castillo M, Bonilla-Moreno R, Aleman-Lazarini L, Meraz-Rios MA, Orozco L, Cedillo-Barron L, Cordova EJ and Villegas-Sepulveda N: A subpopulation of the K562 cells are killed by curcumin treatment after G2/M arrest and mitotic catastrophe. PLoS One. 11:e01659712016. View Article : Google Scholar : PubMed/NCBI

36 

Qadir MI, Naqvi ST and Muhammad SA: Curcumin: A polyphenol with molecular targets for cancer control. Asian Pac J Cancer Prev. 17:2735–2739. 2016.PubMed/NCBI

37 

Chakraborti S, Das L, Kapoor N, Das A, Dwivedi V, Poddar A, Chakraborti G, Janik M, Basu G, Panda D, et al: Curcumin recognizes a unique binding site of tubulin. J Med Chem. 54:6183–6196. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Jackson SJ, Murphy LL, Venema RC, Singletary KW and Young AJ: Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation. Food Chem Toxicol. 60:431–438. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Martínez-Castillo M, Villegas-Sepúlveda N, Meraz-Rios MA, Hernández-Zavala A, Berumen J, Coleman MA, Orozco L and Cordova EJ: Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells. Oncol Lett 15: 6777-6783, 2018.
APA
Martínez-Castillo, M., Villegas-Sepúlveda, N., Meraz-Rios, M.A., Hernández-Zavala, A., Berumen, J., Coleman, M.A. ... Cordova, E.J. (2018). Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells. Oncology Letters, 15, 6777-6783. https://doi.org/10.3892/ol.2018.8112
MLA
Martínez-Castillo, M., Villegas-Sepúlveda, N., Meraz-Rios, M. A., Hernández-Zavala, A., Berumen, J., Coleman, M. A., Orozco, L., Cordova, E. J."Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells". Oncology Letters 15.5 (2018): 6777-6783.
Chicago
Martínez-Castillo, M., Villegas-Sepúlveda, N., Meraz-Rios, M. A., Hernández-Zavala, A., Berumen, J., Coleman, M. A., Orozco, L., Cordova, E. J."Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells". Oncology Letters 15, no. 5 (2018): 6777-6783. https://doi.org/10.3892/ol.2018.8112
Copy and paste a formatted citation
x
Spandidos Publications style
Martínez-Castillo M, Villegas-Sepúlveda N, Meraz-Rios MA, Hernández-Zavala A, Berumen J, Coleman MA, Orozco L and Cordova EJ: Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells. Oncol Lett 15: 6777-6783, 2018.
APA
Martínez-Castillo, M., Villegas-Sepúlveda, N., Meraz-Rios, M.A., Hernández-Zavala, A., Berumen, J., Coleman, M.A. ... Cordova, E.J. (2018). Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells. Oncology Letters, 15, 6777-6783. https://doi.org/10.3892/ol.2018.8112
MLA
Martínez-Castillo, M., Villegas-Sepúlveda, N., Meraz-Rios, M. A., Hernández-Zavala, A., Berumen, J., Coleman, M. A., Orozco, L., Cordova, E. J."Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells". Oncology Letters 15.5 (2018): 6777-6783.
Chicago
Martínez-Castillo, M., Villegas-Sepúlveda, N., Meraz-Rios, M. A., Hernández-Zavala, A., Berumen, J., Coleman, M. A., Orozco, L., Cordova, E. J."Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells". Oncology Letters 15, no. 5 (2018): 6777-6783. https://doi.org/10.3892/ol.2018.8112
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