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Article

HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer

  • Authors:
    • Yan Guo
    • Zhihui Duan
    • Yitao Jia
    • Chaoying Ren
    • Jian Lv
    • Peng Guo
    • Wujie Zhao
    • Bin Wang
    • Suqiao Zhang
    • Yaxing Li
    • Zhongxin Li
  • View Affiliations / Copyright

    Affiliations: Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China, Third Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China
  • Pages: 6629-6635
    |
    Published online on: February 27, 2018
       https://doi.org/10.3892/ol.2018.8124
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Abstract

The present study aimed to evaluate the expression of human epidermal growth factor receptor (HER4) isoforms and their ligand neuregulin 1 (NRG1) isoforms in human primary colorectal cancer (CRC). The mRNA expression of HER4 isoforms JM‑a, JM‑b, CYT1 and CYT2, and their ligand isoforms NRG1 I, II and III in CRC tissues and adjacent normal tissues were quantified by reverse transcription‑quantitative polymerase chain reaction analysis. Univariate analysis and logistic regression analysis were performed to analyze the association between HER4 and NRG1 expression and lymph node metastasis in CRC. The expression levels of CYT1 (P=0.002), CYT2 (P=0.002) and NRG1 type III (P<0.001) were significantly higher in the CRC tissues than in the adjacent normal tissues. The expression of CYT2 was correlated with tumor stage (P=0.018), lymph node status (P=0.015) and tumor‑node‑metastasis (P=0.038) in CRC. The expression of NRG1III was correlated with lymph node metastasis, and the expression of CYT2 was associated with the expression of NRG1III (r=0.691, P<0.01). The logistic regression analysis indicated that expression of CYT2 >50 was a risk factor for lymph node metastasis in CRC. In conclusion the expression levels of CYT1, CYT2 and NRG1III were upregulated in CRC. An expression of CYT‑2 >50 was identified as a risk factor for lymph node metastasis in CRC. Therefore, CY‑2 and NRG1III may be involved in the progression of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Duan Z, Jia Y, Ren C, Lv J, Guo P, Zhao W, Wang B, Zhang S, Li Y, Li Y, et al: HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer. Oncol Lett 15: 6629-6635, 2018.
APA
Guo, Y., Duan, Z., Jia, Y., Ren, C., Lv, J., Guo, P. ... Li, Z. (2018). HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer. Oncology Letters, 15, 6629-6635. https://doi.org/10.3892/ol.2018.8124
MLA
Guo, Y., Duan, Z., Jia, Y., Ren, C., Lv, J., Guo, P., Zhao, W., Wang, B., Zhang, S., Li, Y., Li, Z."HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer". Oncology Letters 15.5 (2018): 6629-6635.
Chicago
Guo, Y., Duan, Z., Jia, Y., Ren, C., Lv, J., Guo, P., Zhao, W., Wang, B., Zhang, S., Li, Y., Li, Z."HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer". Oncology Letters 15, no. 5 (2018): 6629-6635. https://doi.org/10.3892/ol.2018.8124
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Duan Z, Jia Y, Ren C, Lv J, Guo P, Zhao W, Wang B, Zhang S, Li Y, Li Y, et al: HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer. Oncol Lett 15: 6629-6635, 2018.
APA
Guo, Y., Duan, Z., Jia, Y., Ren, C., Lv, J., Guo, P. ... Li, Z. (2018). HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer. Oncology Letters, 15, 6629-6635. https://doi.org/10.3892/ol.2018.8124
MLA
Guo, Y., Duan, Z., Jia, Y., Ren, C., Lv, J., Guo, P., Zhao, W., Wang, B., Zhang, S., Li, Y., Li, Z."HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer". Oncology Letters 15.5 (2018): 6629-6635.
Chicago
Guo, Y., Duan, Z., Jia, Y., Ren, C., Lv, J., Guo, P., Zhao, W., Wang, B., Zhang, S., Li, Y., Li, Z."HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer". Oncology Letters 15, no. 5 (2018): 6629-6635. https://doi.org/10.3892/ol.2018.8124
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