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Article

Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia

  • Authors:
    • Adrian Krygier
    • Dagmara Szmajda
    • Marta Żebrowska
    • Agnieszka Jeleń
    • Ewa Balcerczak
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Laboratory of Molecular Diagnostics and Pharmacogenomics, Medical University of Lodz, 90‑151 Lodz, Poland
  • Pages: 6733-6738
    |
    Published online on: March 1, 2018
       https://doi.org/10.3892/ol.2018.8143
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Abstract

The aim of the present study was to evaluate the mRNA expression level of the runt‑related transcription factor 1 (RUNX1) and runt‑related transcription factor 3 (RUNX3) genes in patients with acute myeloid leukemia (AML). The etiology of AML is not yet fully known, but certain genetic factors may contribute to its manifestation. The RUNX1 and RUNX3 genes have been demonstrated to serve a role in the transcription process. The group investigated in the present study included 43 patients diagnosed with AML, and the relative RUNX1 and RUNX3 expression levels were determined using reverse transcription‑quantitative polymerase chain reaction. The results indicated that RUNX1 and RUNX3 expression was associated with clinicopathological features, including sex and mortality risk. Expression levels of the RUNX1 gene were higher and more variable among females (P=0.044), and mortality was more frequent among patients with a higher RUNX3 expression level (P=0.036). The data obtained from the present study suggested that RUNX3 expression may have potential value as a prognostic factor; furthermore, sex is potentially a factor that may affect the difference in RUNX1 gene expression level among females and males. Further analyses in this field will aid in the identification and elucidation of the molecular basis of leukemia.
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1 

Saultz JN and Garzon R: Acute myeloid leukemia: A concise review. J Clin Med. 5:pii: E33. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Fey MF and Buske C: ESMO Guidelines Working Group: Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24 Suppl 6:vi138–vi143. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Thein MS, Ershler WB, Jemal A, Yates JW and Baer MR: Outcome of older patients with acute myeloid leukemia: An analysis of SEER data over three decades. Cancer. 119:2720–2727. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Döhner H, Weisdorf DJ and Bloomfield CD: Acute myeloid leukemia. N Engl J Med. 375:1136–1152. 2015. View Article : Google Scholar

5 

Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, et al: Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 129:424–447. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Ito Y: Oncogenic potential of the RUNX gene family: ‘Overview’. Oncogene. 23:4198–4208. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Cheng CK, Li L, Cheng SH, Lau KM, Chan NP, Wong RS, Shing MM, Li CK and Ng MH: Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia. Blood. 112:3391–3402. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Ito Y, Bae SC and Chuang LS: The RUNX family: Developtal regulators in cancer. Nature Reviews Cancer. 15:81–95. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Medinger M, Lengerke C and Passweg J: Novel prognostic and therapeutic mutations in acute myeloid leukemia. Cancer Genomics Proteomics. 13:317–329. 2016.PubMed/NCBI

10 

Tracey WD and Speck NA: Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate. Semin Cell Dev Biol. 11:337–342. 2000. View Article : Google Scholar : PubMed/NCBI

11 

GeneCards® Human Gene Database: RUNX3 gene. http://www.genecards.org/cgi-bin/carddisp.pl?gene=RUNX3April 24–2017

12 

Asou N: The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications. Crit Rev Oncol Hematol. 45:129–150. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Bangsow C, Rubins N, Glusman G, Bernstein Y, Negreanu V, Goldenberg D, Lotem J, Ben-Asher E, Lancet D, Levanon D and Groner Y: The RUNX3 gene-sequence, structure and regulated expression. Gene. 279:221–232. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Otto F, Stock M, Fliegauf M, Fenaux P, Preudhomme C and Lübbert M: Absence of somatic mutations within the Runt domain of AML2/RUNX3 in acute myeloid leukaemia. Leukemia. 17:1677–1678. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, et al: RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res. 66:6512–6520. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Bae SC and Choi JK: Tumor suppressor activity of RUNX3. Oncogene. 23:4336–4340. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Guo C, Ding J, Yao L, Sun L, Lin T, Song Y, Sun L and Fan D: Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1. Int J Cancer. 116:155–160. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Kabel A, Zamzami F, Al-Talhi M, Al-Dwila K and Hamza R: Acute myeloid leukemia: A focus on risk factors, clinical presentation, diagnosis and possible lines of management. Cancer Res Treat. 5:62–67. 2017.

19 

Silver N, Best S, Jiang J and Thein SL: Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR. BMC Mol Biol. 7:332006. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Fu L, Fu H, Tian L, Xu K, Hu K, Wang J, Wang J, Jing H, Shi J and Ke X: High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia. Oncotarget. 7:15828–15839. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Lam K and Zhang DE: RUNX1 and RUNX1-ETO: Roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed). 17:1120–1139. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Ge T, Yin M, Yang M, Liu T and Lou G: MicroRNA-302b suppresses human epithelial ovarian cancer cell growth by targeting RUNX1. Cell Physiol Biochem. 34:2209–2220. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Ferrari N, Mohammed ZM, Nixon C, Mason SM, Mallon E, McMillan DC, Morris JS, Cameron ER, Edwards J and Blyth K: Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer. PLoS One. 9:e1007592014. View Article : Google Scholar : PubMed/NCBI

25 

Silva FP, Morolli B, Storlazzi CT, Anelli L, Wessels H, Bezrookove V, Kluin-Nelemans HC and Giphart-Gassler M: Identification of RUNX1/AML1 as a classical tumor suppressor gene. Oncogene. 22:538–547. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Osato M: Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia. Oncogene. 23:4284–4296. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Ben-Ami O, Friedman D, Leshkowitz D, Goldenberg D, Orlovsky K, Pencovich N, Lotem J, Tanay A and Groner Y: Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1. Cell Rep. 4:1131–1143. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, et al: Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. J Clin Invest. 123:3876–3888. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Goyama S, Huang G, Kurokawa M and Mulloy JC: Posttranslational modifications of RUNX1 as potential anticancer targets. Oncogene. 34:3483–3492. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Wilkinson AC, Ballabio E, Geng H, North P, Tapia M, Kerry J, Biswas D, Roeder RG, Allis CD, Melnick A, et al: RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep. 3:116–127. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae SC, et al: RUNX3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 5:946–954. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y and Littman DR: Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 111:621–633. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Li QL, Ito K, Sakakura C, Fukamachi H, Inoue Ki, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, et al: Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell. 109:113–124. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Jiang Y, Tong D, Lou G, Zhang Y and Geng J: Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines. Pathobiology. 75:244–251. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Lacayo NJ, Meshinchi S, Kinnunen P, Yu R, Wang Y, Stuber CM, Douglas L, Wahab R, Becton DL, Weinstein H, et al: Gene expression profiles at diagnosis in de novo child-hood AML patients identify FLT3 mutations with good clinical outcomes. Blood. 104:2646–2654. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Krygier A, Szmajda D, Żebrowska M, Jeleń A and Balcerczak E: Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia. Oncol Lett 15: 6733-6738, 2018.
APA
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., & Balcerczak, E. (2018). Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia. Oncology Letters, 15, 6733-6738. https://doi.org/10.3892/ol.2018.8143
MLA
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., Balcerczak, E."Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia". Oncology Letters 15.5 (2018): 6733-6738.
Chicago
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., Balcerczak, E."Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia". Oncology Letters 15, no. 5 (2018): 6733-6738. https://doi.org/10.3892/ol.2018.8143
Copy and paste a formatted citation
x
Spandidos Publications style
Krygier A, Szmajda D, Żebrowska M, Jeleń A and Balcerczak E: Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia. Oncol Lett 15: 6733-6738, 2018.
APA
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., & Balcerczak, E. (2018). Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia. Oncology Letters, 15, 6733-6738. https://doi.org/10.3892/ol.2018.8143
MLA
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., Balcerczak, E."Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia". Oncology Letters 15.5 (2018): 6733-6738.
Chicago
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., Balcerczak, E."Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia". Oncology Letters 15, no. 5 (2018): 6733-6738. https://doi.org/10.3892/ol.2018.8143
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