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Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway

  • Authors:
    • Jianjian Zhuang
    • Yange Liu
    • Qingxia Yuan
    • Junsong Liu
    • Yan Liu
    • Hongdong Li
    • Di Wang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Superhard Materials, Jilin University, Changchun, Jilin 130012, P.R. China, School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China
    Copyright: © Zhuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6291-6296
    |
    Published online on: March 2, 2018
       https://doi.org/10.3892/ol.2018.8162
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Abstract

Acute promyelocytic leukemia is frequently associated with dizziness, fever, nausea, hematochezia and anemia. Blue light, or light with wavelengths of 400‑480 nm, transmits high levels of energy. The aim of the present study was to determine the pro-apoptotic effects of blue light (wavelength, 456 nm; radiation power, 0.25 mW/cm2) and the underlying mechanisms in a human promyelocytic leukemia cell line (HL60). Blue light reduced the viability and enhanced the mortality of HL60 cells in a time‑dependent manner. Exposure to blue light for 24 h caused depolarization of the mitochondrial membrane potential and the overproduction of reactive oxygen species in HL60 cells. In a nude mouse model, 9‑day exposure to blue light markedly suppressed the growth of HL60‑xenografted tumors; however, it had no effect on hepatic and renal tissues. In addition, blue light abrogated the expression of B‑cell lymphoma (Bcl)‑2 and Bcl extra‑long, while enhancing the levels of Bcl‑2‑associated X protein, cytochrome c, and cleaved caspases‑3 and ‑9 in tumor tissues. The results suggested that the pro‑apoptotic effects of blue light in human promyelocytic leukemia cells may be associated with the mitochondrial apoptosis signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhuang J, Liu Y, Yuan Q, Liu J, Liu Y, Li H and Wang D: Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway. Oncol Lett 15: 6291-6296, 2018.
APA
Zhuang, J., Liu, Y., Yuan, Q., Liu, J., Liu, Y., Li, H., & Wang, D. (2018). Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway. Oncology Letters, 15, 6291-6296. https://doi.org/10.3892/ol.2018.8162
MLA
Zhuang, J., Liu, Y., Yuan, Q., Liu, J., Liu, Y., Li, H., Wang, D."Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway". Oncology Letters 15.5 (2018): 6291-6296.
Chicago
Zhuang, J., Liu, Y., Yuan, Q., Liu, J., Liu, Y., Li, H., Wang, D."Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway". Oncology Letters 15, no. 5 (2018): 6291-6296. https://doi.org/10.3892/ol.2018.8162
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang J, Liu Y, Yuan Q, Liu J, Liu Y, Li H and Wang D: Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway. Oncol Lett 15: 6291-6296, 2018.
APA
Zhuang, J., Liu, Y., Yuan, Q., Liu, J., Liu, Y., Li, H., & Wang, D. (2018). Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway. Oncology Letters, 15, 6291-6296. https://doi.org/10.3892/ol.2018.8162
MLA
Zhuang, J., Liu, Y., Yuan, Q., Liu, J., Liu, Y., Li, H., Wang, D."Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway". Oncology Letters 15.5 (2018): 6291-6296.
Chicago
Zhuang, J., Liu, Y., Yuan, Q., Liu, J., Liu, Y., Li, H., Wang, D."Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway". Oncology Letters 15, no. 5 (2018): 6291-6296. https://doi.org/10.3892/ol.2018.8162
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