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Article

NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study

  • Authors:
    • Yanlan Yu
    • Shan Li
    • Huiyan Zhang
    • Xuqing Zhang
    • Deyu Guo
    • Jiqiang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, P.R. China, Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 6592-6598
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/ol.2018.8169
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Abstract

The transcription factor neuron‑restrictive silencer factor (NRSF), also termed repressor element 1-silencing transcription factor (REST), has been previously demonstrated to repress the expression of neuronal genes in non-neuronal cells, facilitating the controlled development and organization of nerve tissue. However, previous studies have reported NRSF/REST to be upregulated or downregulated in multiple types of carcinoma. Liver diseases are a major global health concern, with cirrhosis and liver carcinoma among the most common causes of mortality worldwide. A previous study demonstrated that there were >400 NRSF/REST target genes in mouse liver cells; however, the expression profile of NRSF/REST in human liver disease remains unclear. The present study examined NRSF/REST expression in human normal and liver carcinoma samples using tissue microarray immunohistochemistry. The results demonstrated that in normal liver tissues, NRSF/REST can be detected in the cytoplasm and nuclei of the cell; whereas in the liver carcinoma tissue, NRSF/REST is only detected in the cytoplasm. Furthermore, the number of samples with high levels of NRSF/REST was significantly lower in cholangiocellular carcinoma samples compared with normal tissues. Additionally, no detectable sex‑ or age‑associated differences were identified in NRSF/REST expression among all the tissues examined. In conclusion, the results of the present study revealed nuclear loss of NRSF/REST in hepatic carcinomas and decreased expression of NRSF/REST in cholangiocellular carcinoma, indicating that the cytoplasmic translocation of NRSF/REST may be involved in liver tumorigenesis. A low expression level of NRSF/REST may be a novel biomarker for cholangiocellular carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Li S, Zhang H, Zhang X, Guo D and Zhang J: NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study. Oncol Lett 15: 6592-6598, 2018.
APA
Yu, Y., Li, S., Zhang, H., Zhang, X., Guo, D., & Zhang, J. (2018). NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study. Oncology Letters, 15, 6592-6598. https://doi.org/10.3892/ol.2018.8169
MLA
Yu, Y., Li, S., Zhang, H., Zhang, X., Guo, D., Zhang, J."NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study". Oncology Letters 15.5 (2018): 6592-6598.
Chicago
Yu, Y., Li, S., Zhang, H., Zhang, X., Guo, D., Zhang, J."NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study". Oncology Letters 15, no. 5 (2018): 6592-6598. https://doi.org/10.3892/ol.2018.8169
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Li S, Zhang H, Zhang X, Guo D and Zhang J: NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study. Oncol Lett 15: 6592-6598, 2018.
APA
Yu, Y., Li, S., Zhang, H., Zhang, X., Guo, D., & Zhang, J. (2018). NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study. Oncology Letters, 15, 6592-6598. https://doi.org/10.3892/ol.2018.8169
MLA
Yu, Y., Li, S., Zhang, H., Zhang, X., Guo, D., Zhang, J."NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study". Oncology Letters 15.5 (2018): 6592-6598.
Chicago
Yu, Y., Li, S., Zhang, H., Zhang, X., Guo, D., Zhang, J."NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray study". Oncology Letters 15, no. 5 (2018): 6592-6598. https://doi.org/10.3892/ol.2018.8169
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