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Article

Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer

  • Authors:
    • Hideko Imaizumi
    • Keiichiro Ishibashi
    • Seiichi Takenoshita
    • Hideyuki Ishida
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350‑8550, Japan, Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan
  • Pages: 6450-6456
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/ol.2018.8170
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Abstract

Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a prognostic and predictive biomarker for disease recurrence and therapeutic outcomes. The current study investigated the expression of AQP1 in surgically resected specimens from 268 patients with stage 0‑IV CRC. AQP1 expression was positive in 112 (41.8%) patients, and was significantly associated with left‑sided tumors (P<0.01) and with aggressive tumor phenotypes, including depth of invasion (P=0.03), lymph node metastasis (P=0.03), lymphatic invasion (P<0.01) and venous invasion (P<0.01). However, AQP1 expression had no significant prognostic effect on disease‑free survival (DFS) in patients with stage II and III CRC following curative surgery. In 84 stage II and III patients who were administered 5‑fluorouracil‑based adjuvant chemotherapy, positive AQP1 expression was associated with an increased DFS rate compared with that of AQP1‑negative patients (P=0.05). Additionally, these results identified that receiving adjuvant chemotherapy was not beneficial to patients with AQP1‑negative tumors. This suggests that the expression of AQP1 may be a candidate biomarker predictive of response to 5‑fluorouracil‑based adjuvant chemotherapy following surgery in patients with stage II and III CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Imaizumi H, Ishibashi K, Takenoshita S and Ishida H: Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncol Lett 15: 6450-6456, 2018.
APA
Imaizumi, H., Ishibashi, K., Takenoshita, S., & Ishida, H. (2018). Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncology Letters, 15, 6450-6456. https://doi.org/10.3892/ol.2018.8170
MLA
Imaizumi, H., Ishibashi, K., Takenoshita, S., Ishida, H."Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer". Oncology Letters 15.5 (2018): 6450-6456.
Chicago
Imaizumi, H., Ishibashi, K., Takenoshita, S., Ishida, H."Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer". Oncology Letters 15, no. 5 (2018): 6450-6456. https://doi.org/10.3892/ol.2018.8170
Copy and paste a formatted citation
x
Spandidos Publications style
Imaizumi H, Ishibashi K, Takenoshita S and Ishida H: Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncol Lett 15: 6450-6456, 2018.
APA
Imaizumi, H., Ishibashi, K., Takenoshita, S., & Ishida, H. (2018). Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncology Letters, 15, 6450-6456. https://doi.org/10.3892/ol.2018.8170
MLA
Imaizumi, H., Ishibashi, K., Takenoshita, S., Ishida, H."Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer". Oncology Letters 15.5 (2018): 6450-6456.
Chicago
Imaizumi, H., Ishibashi, K., Takenoshita, S., Ishida, H."Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer". Oncology Letters 15, no. 5 (2018): 6450-6456. https://doi.org/10.3892/ol.2018.8170
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