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Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway

  • Authors:
    • Qian‑Ming Qi
    • Yin‑Cun Xue
    • Jian Lv
    • Di Sun
    • Jian‑Xin Du
    • Sheng‑Qiang Cai
    • Yun‑He Li
    • Tian‑Cun Gu
    • Mu‑Bing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory, The 359th Hospital of The People's Liberation Army, Zhenjiang, Jiangsu 212000, P.R. China, Department of General Surgery, Jingjiang People's Hospital, Taizhou, Jiangsu 214500, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6400-6408
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/ol.2018.8177
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Abstract

Ginkgolic acids may induce malignant cell death via the B‑cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl‑2 apoptosis pathway. Concurrently, apoptosis, autophagy and mitochondrial dysfunction may also be involved in bringing about this endpoint. The anticancer effect of Ginkgolic acids (GAs) was investigated using the HepG2 cell line. The median lethal dose of the GAs of the HepG2 was measured via an MTT assay, the dose‑response curves were evaluated and changes in cell morphology were monitored by microscopy. Autophagy in HepG2 cells was down regulated using 3‑methyladenine (3‑MA) or Beclin‑1‑specific small interfering RNA (siRNA) and the expression of apoptosis associated proteins caspase‑3, Bax/Bcl‑2, and the autophagy‑associated protein 5 and microtubule‑associated protein 1A/1B‑light chain 3 in the GA‑treated HepG2 cells were all measured by western blot analysis. The level of apoptosis in the GA‑treated cells was also assessed using terminal deoxynucleotidyl‑transferase‑mediated dUTP nick‑end labeling (TUNEL) assay, and the mitochondrial membrane potential (Δψm) was detected by immunofluorescence. The results of the MTT and TUNEL assays indicated that the proliferation of HepG2 cells treated with GAs was significantly reduced compared with the control group, and the rate of the inhibition was dose‑dependent. Western blot analysis indicated that treatment with the Gas induced apoptosis and autophagy in the HepG2 cells. The Δψm of the GA‑treated HepG2 cells was decreased compared with the control, as monitored by immunofluorescence. However, upon the administration of 3‑MA or Beclin‑1‑specific siRNAs (inhibitors of the autophagy), the expression levels of the apoptosis‑ and autophagy‑associated proteins were decreased. In conclusion, the results of the present study indicated that GAs are potent anticancer agents that function through a combination of the apoptosis, autophagy and mitochondrial pathways.
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1 

Shimizuguchi T, Nihei K, Okano T, Machitori Y, Ito K and Karasawa K: A comparison of clinical outcomes between three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer. Int J Clin Oncol. 22:373–379. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Verma V, Moreno AC and Lin SH: Advances in radiotherapy management of esophageal cancer. J Clin Med. 5:pii: E91. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Yang Y, Hu Y and Wang H: Targeting antitumor immune response for enhancing the efficacy of photodynamic therapy of cancer: Recent advances and future perspectives. Oxid Med Cell Longev. 2016:52740842016. View Article : Google Scholar : PubMed/NCBI

4 

Yeku O and Slovin SF: Immune therapy for prostate cancer. Cancer J. 22:334–341. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Friese CR, Li Y, Bondarenko I, Hofer TP, Ward KC, Hamilton AS, Deapen D, Kurian AW and Katz SJ: Chemotherapy decisions and patient experience with the recurrence score assay for early-stage breast cancer. Cancer. 123:43–51. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Lohiya V, Aragon-Ching JB and Sonpavde G: Role of chemotherapy and mechanisms of resistance to chemotherapy in metastatic castration-resistant prostate cancer. Clin Med Insights Oncol. 10 Suppl 1:S57–S66. 2016.

7 

Sun Y, Guan Z, Liang L, Cheng Y, Zhou J, Li J and Xu Y: NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression. Int J Oncol. 48:225–234. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hsu YL, Hung JY, Tsai EM, Wu CY, Ho YW, Jian SF, Yen MC, Chang WA, Hou MF and Kuo PL: Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROalpha and S100A8/A9. Oncol Rep. 34:2889–2900. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Thoenes L, Hoehn M, Kashirin R, Ogris M, Arnold GJ, Wagner E and Guenther M: In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy. J Proteomics. 73:1342–1354. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Oh J, Hwang IH, Hong CE, Lyu SY and Na M: Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity. J Enzyme Inhib Med Chem. 28:565–568. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wang H, Zhou CC, Feng Y, Dai LN, Chen J, Chen SX, Li XY, Liu YR and Zhang P: The effect of ginkgolic acids on multidrug resistance in oral squamous cell carcinoma. Hua Xi Kou Qiang Yi Xue Za Zhi. 28:668–671. 2010.(In Chinese). PubMed/NCBI

12 

Fuzzati N, Pace R and Villa F: A simple HPLC-UV method for the assay of ginkgolic acids in Ginkgo biloba extracts. Fitoterapia. 74:247–256. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Long R, Yin R and Zhen Y: Partial purification and analysis of allergenicity, immunogenicity of Ginkgo biloba L. pollen. Hua Xi Yi Ke Da Xue Xue Bao. 23:429–432. 1992.(In Chines). PubMed/NCBI

14 

Chao JC and Chu CC: Effects of Ginkgo biloba extract on cell proliferation and cytotoxicity in human hepatocellular carcinoma cells. World J Gastroenterol. 10:37–41. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Lee JH, Kim YG, Ryu SY, Cho MH and Lee J: Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation. Int J Food Microbiol. 174:47–55. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Thompson AJ, McGonigle I, Duke R, Johnston GA and Lummis SC: A single amino acid determines the toxicity of Ginkgo biloba extracts. FASEB J. 26:1884–1891. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Ma J, Duan W, Han S, Lei J, Xu Q, Chen X, Jiang Z, Nan L, Li J, Chen K, et al: Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis. Oncotarget. 6:20993–21003. 2015.PubMed/NCBI

18 

Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 290:1717–1721. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Bu X, Zhao Y, Zhang Z, Wang M, Li M and Yan Y: Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress. Am J Cancer Res. 6:924–936. 2016.PubMed/NCBI

20 

Bu XF, Wang MB, Zhang ZJ, Zhao YH, Li M and Yan YL: Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced cell death of stomach adenocarcinoma cells in vitro. Int J Oncol. 47:679–689. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Kania E, Pajak B, O'Prey J, Gonzalez Sierra P, Litwiniuk A, Urbańska K, Ryan KM and Orzechowski A: Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism. FEBS J. 284:1370–1387. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Anding AL and Baehrecke EH: Autophagy in cell life and cell death. Curr Top Dev Biol. 114:67–91. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Lee YJ, Lee GJ, Yi SS, Heo SH, Park CR, Nam HS, Cho MK and Lee SH: Cisplatin and resveratrol induce apoptosis and autophagy following oxidative stress in malignant mesothelioma cells. Food Chem Toxicol. 97:96–107. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Kumari KK and Setty OH: Protective effect of Phyllanthus fraternus against mitochondrial dysfunction induced by co-administration of cisplatin and cyclophosphamide. J Bioenerg Biomembr. 44:179–188. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Hackenberg T, Juul T, Auzina A, Gwizdz S, Malolepszy A, Van Der Kelen K, Dam S, Bressendorff S, Lorentzen A, Roepstorff P, et al: Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Plant Cell. 25:4616–4626. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Yang XM, Wang YF, Li YY and Ma HL: Thermal stability of ginkgolic acids from Ginkgo biloba and the effects of ginkgol C17:1 on the apoptosis and migration of SMMC7721 cells. Fitoterapia. 98:66–76. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Zhou C, Li X, Du W, Feng Y, Kong X, Li Y, Xiao L and Zhang P: Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. Chemotherapy. 56:393–402. 2010. View Article : Google Scholar : PubMed/NCBI

28 

López-Terrada D, Cheung SW, Finegold MJ and Knowles BB: Hep G2 is a hepatoblastoma-derived cell line. Hum Pathol. 40:1512–1515. 2009. View Article : Google Scholar

29 

Schaaf MB, Keulers TG, Vooijs MA and Rouschop KM: LC3/GABARAP family proteins: Autophagy-(un)related functions. FASEB J. 30:3961–3978. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Qi Z, Dong W, Shi W, Wang R, Zhang C, Zhao Y, Ji X, Liu KJ and Luo Y: Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke. Transl Stroke Res. 6:198–206. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Münz C: Autophagy proteins in phagocyte endocytosis and exocytosis. Front Immunol. 8:11832017. View Article : Google Scholar : PubMed/NCBI

32 

Nascimbeni AC, Codogno P and Morel E: Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics. FEBS J. 284:1267–1278. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Lemasters JJ: Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol. 2:749–754. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kim J and Hurria A: Determining chemotherapy tolerance in older patients with cancer. J Natl Compr Canc Netw. 11:1494–1502. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Kalsi T, Babic-Illman G, Ross PJ, Maisey NR, Hughes S, Fields P, Martin FC, Wang Y and Harari D: The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people. Br J Cancer. 112:1435–1444. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Lara-Guerra H and Roth JA: Gene therapy for lung cancer. Crit Rev Oncog. 21:115–124. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Yang X, Qian Z, Chen J, Zhu W and Xie J: Study on antitumor activities of ginkgolic acids from Ginkgo sarcotestas in vitro. Zhong Yao Cai. 27:40–42. 2004.(In Chinese). PubMed/NCBI

38 

Zhou CC, Du W, Wen Z, Li JY and Zhang P: Effects of natural plant ginkgolic acids on the apoptosis of human Hep-2 cancer cells. Sichuan Da Xue Xue Bao Yi Xue Ban. 40:459–461. 2009.(In Chinese). PubMed/NCBI

39 

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, et al: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4:151–175. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Wesselborg S and Stork B: Autophagy signal transduction by ATG proteins: From hierarchies to networks. Cell Mol Life Sci. 72:4721–4757. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Hetz C: The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 13:89–102. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Levine B, Sinha SC and Kroemer G: Bcl-2 family members: Dual regulators of apoptosis and autophagy. Autophagy. 4:600–606. 2008. View Article : Google Scholar

43 

Kale J, Osterlund EJ and Andrews DW: BCL-2 family proteins: Changing partners in the dance towards death. Cell Death Differ. 25:65–80. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD and Levine B: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122:927–939. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Lomonosova E and Chinnadurai G: BH3-only proteins in apoptosis and beyond: An overview. Oncogene. 27 Suppl 1:S2–S19. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T and Simon HU: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 8:1124–1132. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Gong A, Ye S, Xiong E, Guo W, Zhang Y, Peng W, Shao G, Jin J, Zhang Z, Yang J and Gao J: Autophagy contributes to ING4-induced glioma cell death. Exp Cell Res. 319:1714–1723. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qi QM, Xue YC, Lv J, Sun D, Du JX, Cai SQ, Li YH, Gu TC and Wang MB: Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway. Oncol Lett 15: 6400-6408, 2018.
APA
Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S. ... Wang, M. (2018). Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway. Oncology Letters, 15, 6400-6408. https://doi.org/10.3892/ol.2018.8177
MLA
Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S., Li, Y., Gu, T., Wang, M."Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway". Oncology Letters 15.5 (2018): 6400-6408.
Chicago
Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S., Li, Y., Gu, T., Wang, M."Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway". Oncology Letters 15, no. 5 (2018): 6400-6408. https://doi.org/10.3892/ol.2018.8177
Copy and paste a formatted citation
x
Spandidos Publications style
Qi QM, Xue YC, Lv J, Sun D, Du JX, Cai SQ, Li YH, Gu TC and Wang MB: Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway. Oncol Lett 15: 6400-6408, 2018.
APA
Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S. ... Wang, M. (2018). Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway. Oncology Letters, 15, 6400-6408. https://doi.org/10.3892/ol.2018.8177
MLA
Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S., Li, Y., Gu, T., Wang, M."Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway". Oncology Letters 15.5 (2018): 6400-6408.
Chicago
Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S., Li, Y., Gu, T., Wang, M."Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway". Oncology Letters 15, no. 5 (2018): 6400-6408. https://doi.org/10.3892/ol.2018.8177
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