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Article Open Access

MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1

  • Authors:
    • Sheng Zhou
    • Min Xiong
    • Guo Dai
    • Ling Yu
    • Zhengpei Zhang
    • Jie Chen
    • Weichun Guo
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Orthopedics, Dongfeng General Hospital, Shiyan, Hubei 442001, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6947-6956
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/ol.2018.8180
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Abstract

Osteosarcoma is the most frequent primary malignant bone tumor. An increasing body of evidence has suggested that microRNAs (miRNA/miRs) have emerged as critical regulators in the initiation and progression of osteosarcoma. The present study explored the biological function of miR‑192‑5p and ubiquitin‑specific protease 1 (USP1), and investigated whether miR‑192‑5p could directly interact with USP1 in osteosarcoma. The results revealed that miR‑192‑5p was significantly downregulated in osteosarcoma tissues and cell lines, while a reverse expression profile of USP1 was observed. Ectopic expression of miR‑192‑5p restrained cell proliferation, apoptosis, migration and invasion. In addition, it increased the sensitivity of osteosarcoma cells to cisplatin. USP1 was also observed to be a direct target gene of miR‑192‑5p in osteosarcoma. Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo‑sensitivity; however, it could be partially reversed via the overexpression of miR‑192‑5p in osteosarcoma cell lines. Taken together, the present study demonstrated that miR‑192‑5p suppressed the initiation and progression of osteosarcoma by targeting USP1. Therefore, miR‑192‑5p may serve as a valuable biomarker and the miR‑192‑5p/USP1 axis may function as a novel therapeutic target for osteosarcoma.
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1 

Geng S, Gu L, Ju F, Zhang H, Wang Y, Tang H, Bi Z and Yang C: MicroRNA-224 promotes the sensitivity of osteosarcoma cells to cisplatin by targeting Rac1. J Cell Mol Med. 20:1611–1619. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Zhang M, Wang D, Zhu T and Yin R: miR-214-5p targets ROCK1 and suppresses proliferation and invasion of human osteosarcoma cells. Oncol Res. 25:75–81. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Zhang Z, Zhang M, Chen Q and Zhang Q: Downregulation of microRNA-145 promotes epithelial-mesenchymal transition via regulating Snail in osteosarcoma. Cancer Gene Ther. 24:83–88. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the surveillance, epidemiology, and end results program. Cancer. 115:1531–1543. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Chen B, Huang Z, Zhang Y, Chen Y and Li Z: MicroRNA-145 suppresses osteosarcoma metastasis via targeting MMP16. Cell Physiol Biochem. 37:2183–2193. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Wu W, Dang S, Feng Q, Liang J, Wang Y and Fan N: MicroRNA-542-3p inhibits the growth of hepatocellular carcinoma cells by targeting FZD7/Wnt signaling pathway. Biochem Biophys Res Commun. 482:100–105. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Tormo E, Adam-Artigues A, Ballester S, Pineda B, Zazo S, González-Alonso P, Albanell J, Rovira A, Rojo F, Lluch A and Eroles P: The role of miR-26a and miR-30b in HER2+ breast cancer trastuzumab resistance and regulation of the CCNE2 gene. Sci Rep. 7:413092017. View Article : Google Scholar : PubMed/NCBI

9 

Yang T, Zhao P, Rong Z, Li B, Xue H, You J, He C, Li W, He X, Lee RJ, et al: Anti-tumor efficiency of lipid-coated cisplatin nanoparticles co-loaded with MicroRNA-375. Theranostics. 6:142–154. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zeng JF, Ma XQ, Wang LP and Wang W: MicroRNA-145 exerts tumor-suppressive and chemo-resistance lowering effects by targeting CD44 in gastric cancer. World J Gastroenterol. 23:2337–2345. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Wei R, Yang Q, Han B, Li Y, Yao K, Yang X, Chen Z, Yang S, Zhou J, Li M, et al: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. Oncotarget. 8:16633–16641. 2017.PubMed/NCBI

12 

Miao Y, Zheng W, Li N, Su Z, Zhao L, Zhou H and Jia L: MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway. Sci Rep. 7:419422017. View Article : Google Scholar : PubMed/NCBI

13 

Yan X, Zhu Z, Xu S, Yang LN, Liao XH, Zheng M, Yang D, Wang J, Chen D, Wang L, et al: MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways. Sci Rep. 7:459152017. View Article : Google Scholar : PubMed/NCBI

14 

Li B, Zhang S, Shen H and Li C: MicroRNA-144-3p suppresses gastric cancer progression by inhibiting epithelial-to-mesenchymal transition through targeting PBX3. Biochem Biophys Res Commun. 484:241–247. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Feng S, Cong S, Zhang X, Bao X, Wang W, Li H, Wang Z, Wang G, Xu J, Du B, et al: MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res. 39:6669–6678. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Lian J, Jing Y, Dong Q, Huan L, Chen D, Bao C, Wang Q, Zhao F, Li J, Yao M, et al: miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget. 7:2672–2683. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, Li Y and Wang Y: Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. Tumour Biol. 37:15211–15220. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Grabbe C, Husnjak K and Dikic I: The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol. 12:295–307. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, et al: A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 10:298–304. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Sourisseau T, Helissey C, Lefebvre C, Ponsonnailles F, Malka-Mahieu H, Olaussen KA, André F, Vagner S and Soria JC: Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance. Cell Cycle. 15:295–302. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Garcia-Santisteban I, Peters GJ, Giovannetti E and Rodríguez JA: USP1 deubiquitinase: Cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy. Mol Cancer. 12:912013. View Article : Google Scholar : PubMed/NCBI

22 

Lee JK, Chang N, Yoon Y, Yang H, Cho H, Kim E, Shin Y, Kang W, Oh YT, Mun GI, et al: USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance. Neuro-Oncol. 18:37–47. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Liu J, Zhu H, Zhong N, Jiang Z, Xu L, Deng Y, Jiang Z, Wang H and Wang J: Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells. Int J Oncol. 49:2549–2557. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Williams SA, Maecker HL, French DM, Liu J, Gregg A, Silverstein LB, Cao TC, Carano RA and Dixit VM: USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell. 146:918–930. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Enneking WF, Spanier SS and Goodman MA: A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res. 106–120. 1980.PubMed/NCBI

26 

Zhang Z, Yu L, Dai G, Xia K, Liu G, Song Q, Tao C, Gao T and Guo W: Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells. Sci Rep. 7:70702017. View Article : Google Scholar : PubMed/NCBI

27 

Wei CH, Wu G, Cai Q, Gao XC, Tong F, Zhou R, Zhang RG, Dong JH, Hu Y and Dong XR: MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway. J Hematol Oncol. 10:1252017. View Article : Google Scholar : PubMed/NCBI

28 

Mahati S, Xiao L, Yang Y, Mao R and Bao Y: miR-29a suppresses growth and migration of hepatocellular carcinoma by regulating CLDN1. Biochem Biophys Res Commun. 486:732–737. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Xiao Q, Yang Y, An Q and Qi Y: MicroRNA-100 suppresses human osteosarcoma cell proliferation and chemo-resistance via ZNRF2. Oncotarget. 8:34678–34686. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Zhang P, Tang WM, Zhang H, Li YQ, Peng Y, Wang J, Liu GN, Huang XT, Zhao JJ, Li G, et al: MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. Br J Cancer. 117:525–534. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Chen LL, Zhang ZJ, Yi ZB and Li JJ: MicroRNA-211-5p suppresses tumour cell proliferation, invasion, migration and metastasis in triple-negative breast cancer by directly targeting SETBP1. Br J Cancer. 117:78–88. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Guo X, Yu L, Zhang Z, Dai G, Gao T and Guo W: miR-335 negatively regulates osteosarcoma stem cell-like properties by targeting POU5F1. Cancer Cell Int. 17:292017. View Article : Google Scholar : PubMed/NCBI

33 

Fromm B, Billipp T, Peck LE, Johansen M, Tarver JE, King BL, Newcomb JM, Sempere LF, Flatmark K, Hovig E and Peterson KJ: A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome. Annu Rev Genet. 49:213–242. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Botla SK, Savant S, Jandaghi P, Bauer AS, Mücke O, Moskalev EA, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, et al: Early epigenetic downregulation of microRNA-192 expression promotes pancreatic cancer progression. Cancer Res. 76:4149–4159. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Geng L, Chaudhuri A, Talmon G, Wisecarver JL, Are C, Brattain M and Wang J: MicroRNA-192 suppresses liver metastasis of colon cancer. Oncogene. 33:5332–5340. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM Jr, Hofmainster C, Alder H, et al: Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell. 30:349–351. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Yang SY, Choi SA, Lee JY, Park AK, Wang KC, Phi JH, Koh EJ, Park WY, Park SH, Hwang DW, et al: miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47. Oncotarget. 6:43712–43730. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Sun J, Fan Z, Lu S, Yang J, Hao T and Huo Q: miR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein. Int J Mol Med. 37:485–492. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Wang Y, Jia LS, Yuan W, Wu Z, Wang HB, Xu T, Sun JC, Cheng KF and Shi JG: Low miR-34a and miR-192 are associated with unfavorable prognosis in patients suffering from osteosarcoma. Am J Transl Res. 7:111–119. 2015.PubMed/NCBI

40 

Das DS, Das A, Ray A, Song Y, Samur MK, Munshi NC, Chauhan D and Anderson KC: Blockade of deubiquitylating enzyme USP1 inhibits DNA repair and triggers apoptosis in multiple myeloma cells. Clin Cancer Res. 23:4280–4289. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Zhiqiang Z, Qinghui Y, Yongqiang Z, Jian Z, Xin Z, Haiying M and Yuepeng G: USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. J Cancer Res Clin Oncol. 138:1231–1238. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Cao Y, Yu L, Dai G, Zhang S, Zhang Z, Gao T and Guo W: Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling. Eur J Pharmacol. 794:77–84. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Yu L, Fan Z, Fang S, Yang J, Gao T, Simões BM, Eyre R, Guo W and Clarke RB: Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling. Oncotarget. 7:33055–33068. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou S, Xiong M, Dai G, Yu L, Zhang Z, Chen J and Guo W: MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. Oncol Lett 15: 6947-6956, 2018.
APA
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., & Guo, W. (2018). MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. Oncology Letters, 15, 6947-6956. https://doi.org/10.3892/ol.2018.8180
MLA
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., Guo, W."MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1". Oncology Letters 15.5 (2018): 6947-6956.
Chicago
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., Guo, W."MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1". Oncology Letters 15, no. 5 (2018): 6947-6956. https://doi.org/10.3892/ol.2018.8180
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou S, Xiong M, Dai G, Yu L, Zhang Z, Chen J and Guo W: MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. Oncol Lett 15: 6947-6956, 2018.
APA
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., & Guo, W. (2018). MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. Oncology Letters, 15, 6947-6956. https://doi.org/10.3892/ol.2018.8180
MLA
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., Guo, W."MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1". Oncology Letters 15.5 (2018): 6947-6956.
Chicago
Zhou, S., Xiong, M., Dai, G., Yu, L., Zhang, Z., Chen, J., Guo, W."MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1". Oncology Letters 15, no. 5 (2018): 6947-6956. https://doi.org/10.3892/ol.2018.8180
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