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Article

High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma

  • Authors:
    • Jian‑Dong Shen
    • Shou‑Zhong Fu
    • Lin‑Ling Ju
    • Yi‑Fang Wang
    • Feng Dai
    • Zhao‑Xiu Liu
    • Han‑Zheng Ji
    • Jian‑Guo Shao
    • Zhao‑Lian Bian
  • View Affiliations / Copyright

    Affiliations: Department of Invasive Technology, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu 226006, P.R. China, Nantong Institute of Liver Diseases, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu 226006, P.R. China, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226021, P.R. China, Library of Nantong Third People's Hospital, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu 226006, P.R. China, Department of Gastroenterology and Hepatology, Nantong Institute of Liver Diseases, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu 226006, P.R. China
  • Pages: 7362-7368
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8189
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Abstract

The present study aimed to illustrate the association of the expression of ubiquitin‑conjugating enzyme E2A (UBE2A) with the clinicopathological parameters and prognosis in hepatocellular carcinoma (HCC). The expression levels of UBE2A mRNA and protein in a total of 276 HCC tissues and six liver cell lines was detected by fluorescent quantitative polymerase chain reaction, western blotting and immunohistochemistry. Statistical analysis was also performed to assess the association of the expression of UBE2A with the clinicopathological parameters and prognosis by the GraphPad Prism and SPSS version 21.0 software. UBE2A mRNA and protein were highly expressed in HCC tissues compared with those in the adjacent normal tissue. Immunohistochemical analysis revealed that UBE2A protein was more strongly stained in the 276 paraffin‑embedded HCC tissues as compared with the 63 adjacent normal tissue. Statistical analysis also demonstrated that UBE2A expression was significantly associated with histological differentiation, TNM stage and vascular invasion of HCC (P<0.05). Notably, HCC patients with a high expression of UBE2A had a shorter survival time as compared with those with a low expression of UBE2A. There results suggested that UBE2A may be involved in the pathogenesis of HCC and may serve as an important prognostic marker. Further exploration of the involvement of UBE2A in HCC development may provide novel therapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Shen JD, Fu SZ, Ju LL, Wang YF, Dai F, Liu ZX, Ji HZ, Shao JG and Bian ZL: High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma. Oncol Lett 15: 7362-7368, 2018.
APA
Shen, J., Fu, S., Ju, L., Wang, Y., Dai, F., Liu, Z. ... Bian, Z. (2018). High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma. Oncology Letters, 15, 7362-7368. https://doi.org/10.3892/ol.2018.8189
MLA
Shen, J., Fu, S., Ju, L., Wang, Y., Dai, F., Liu, Z., Ji, H., Shao, J., Bian, Z."High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma". Oncology Letters 15.5 (2018): 7362-7368.
Chicago
Shen, J., Fu, S., Ju, L., Wang, Y., Dai, F., Liu, Z., Ji, H., Shao, J., Bian, Z."High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma". Oncology Letters 15, no. 5 (2018): 7362-7368. https://doi.org/10.3892/ol.2018.8189
Copy and paste a formatted citation
x
Spandidos Publications style
Shen JD, Fu SZ, Ju LL, Wang YF, Dai F, Liu ZX, Ji HZ, Shao JG and Bian ZL: High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma. Oncol Lett 15: 7362-7368, 2018.
APA
Shen, J., Fu, S., Ju, L., Wang, Y., Dai, F., Liu, Z. ... Bian, Z. (2018). High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma. Oncology Letters, 15, 7362-7368. https://doi.org/10.3892/ol.2018.8189
MLA
Shen, J., Fu, S., Ju, L., Wang, Y., Dai, F., Liu, Z., Ji, H., Shao, J., Bian, Z."High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma". Oncology Letters 15.5 (2018): 7362-7368.
Chicago
Shen, J., Fu, S., Ju, L., Wang, Y., Dai, F., Liu, Z., Ji, H., Shao, J., Bian, Z."High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma". Oncology Letters 15, no. 5 (2018): 7362-7368. https://doi.org/10.3892/ol.2018.8189
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