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Article

Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway

  • Authors:
    • Zhuo Chen
    • Liang Zhao
    • Feng Zhao
    • Guanghai Yang
    • Jian Jun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Thoracic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China
  • Pages: 7433-7437
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8190
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Abstract

The present study investigated the effect of tetrandrine on lung cancer cell growth and apoptosis, and its possible underlying molecular mechanism. A549 human lung cancer cells were incubated with between 2.5 and 10 µM tetrandrine for 12, 24 and 48 h, following which the effect of tetrandrine on cell viability and apoptosis were assessed using an MTT assay and flow cytometry. ELISA and western blotting were used to analyze VEGF activity, and the expression of poly (ADP‑ribose) polymerase (PARP), phosphorylated protein kinase B (Akt), Bcl‑2‑associated X protein (Bax), hypoxia inducible factor (HIF)‑1α and inter‑cellular adhesion molecule‑1 (ICAM‑1). Tetrandrine effectively suppressed the growth of and induced apoptosis in A549 lung cancer cells. The expression of PARP, Bax, intercellular adhesion molecule‑1 (ICAM‑1) and vascular endothelial growth factor (VEGF) was significantly upregulated, and the phosphorylation of Akt and expression of HIF‑1α was significantly suppressed in A549 lung cancer cells. Therefore, tetrandrine may suppress cell viability and induce apoptosis via the VEGF/HIF‑1α/ICAM‑1 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Z, Zhao L, Zhao F, Yang G and Wang JJ: Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway. Oncol Lett 15: 7433-7437, 2018.
APA
Chen, Z., Zhao, L., Zhao, F., Yang, G., & Wang, J.J. (2018). Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway. Oncology Letters, 15, 7433-7437. https://doi.org/10.3892/ol.2018.8190
MLA
Chen, Z., Zhao, L., Zhao, F., Yang, G., Wang, J. J."Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway". Oncology Letters 15.5 (2018): 7433-7437.
Chicago
Chen, Z., Zhao, L., Zhao, F., Yang, G., Wang, J. J."Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway". Oncology Letters 15, no. 5 (2018): 7433-7437. https://doi.org/10.3892/ol.2018.8190
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z, Zhao L, Zhao F, Yang G and Wang JJ: Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway. Oncol Lett 15: 7433-7437, 2018.
APA
Chen, Z., Zhao, L., Zhao, F., Yang, G., & Wang, J.J. (2018). Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway. Oncology Letters, 15, 7433-7437. https://doi.org/10.3892/ol.2018.8190
MLA
Chen, Z., Zhao, L., Zhao, F., Yang, G., Wang, J. J."Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway". Oncology Letters 15.5 (2018): 7433-7437.
Chicago
Chen, Z., Zhao, L., Zhao, F., Yang, G., Wang, J. J."Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway". Oncology Letters 15, no. 5 (2018): 7433-7437. https://doi.org/10.3892/ol.2018.8190
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