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Article

Circulating SH2B1 is associated with an increased risk of gastric cancer

  • Authors:
    • Bo Liu
    • Feng Li
    • Hong‑Peng Zhao
    • Jing‑Bo Chen
    • Yu‑Peng Li
    • Hai‑Hua Yu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 7305-7311
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8196
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Abstract

Gastric cancer (GC) is one of the most common types of cancer in humans and the second leading cause of cancer-associated mortality worldwide. Identifying novel risk factors will facilitate the development of therapeutic strategies to prevent and treat GC. Increased expression of the Src homology 2 B adaptor protein 1 (SH2B1) may stimulate the malignant progression of lung cancer, esophageal cancer and neuroblastoma. However, its function in GC has not yet been investigated. To identify whether increased serum SH2B1 is a risk factor for GC, the present study performed a nested case‑control study of patients within the Chinese cohort study. Levels of serum SH2B1 were measured in 563 patients diagnosed with GC during the follow‑up period and in 1,126 matched healthy controls. The results demonstrated that high levels of serum SH2B1 were associated with an increased GC risk (odds ratio, 3.23; 95% confidence interval, 2.45‑5.65). When analyses were stratified further by sex, age and smoking, an association between increased levels of SH2B1 and GC was identified in males but not in females. Furthermore, the association between SH2B1 levels and GC was more evident in younger than in older participants, and statistically significant in current smokers but not in nonsmokers. These results were not altered following the exclusion of outliers. Furthermore, it was demonstrated that overexpression of SH2B1 contributes to the malignant transformation of normal gastric epithelial cells. Thus, the present study demonstrated that elevated serum SH2B1 levels may increase the risk of GC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu B, Li F, Zhao HP, Chen JB, Li YP and Yu HH: Circulating SH2B1 is associated with an increased risk of gastric cancer. Oncol Lett 15: 7305-7311, 2018.
APA
Liu, B., Li, F., Zhao, H., Chen, J., Li, Y., & Yu, H. (2018). Circulating SH2B1 is associated with an increased risk of gastric cancer. Oncology Letters, 15, 7305-7311. https://doi.org/10.3892/ol.2018.8196
MLA
Liu, B., Li, F., Zhao, H., Chen, J., Li, Y., Yu, H."Circulating SH2B1 is associated with an increased risk of gastric cancer". Oncology Letters 15.5 (2018): 7305-7311.
Chicago
Liu, B., Li, F., Zhao, H., Chen, J., Li, Y., Yu, H."Circulating SH2B1 is associated with an increased risk of gastric cancer". Oncology Letters 15, no. 5 (2018): 7305-7311. https://doi.org/10.3892/ol.2018.8196
Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Li F, Zhao HP, Chen JB, Li YP and Yu HH: Circulating SH2B1 is associated with an increased risk of gastric cancer. Oncol Lett 15: 7305-7311, 2018.
APA
Liu, B., Li, F., Zhao, H., Chen, J., Li, Y., & Yu, H. (2018). Circulating SH2B1 is associated with an increased risk of gastric cancer. Oncology Letters, 15, 7305-7311. https://doi.org/10.3892/ol.2018.8196
MLA
Liu, B., Li, F., Zhao, H., Chen, J., Li, Y., Yu, H."Circulating SH2B1 is associated with an increased risk of gastric cancer". Oncology Letters 15.5 (2018): 7305-7311.
Chicago
Liu, B., Li, F., Zhao, H., Chen, J., Li, Y., Yu, H."Circulating SH2B1 is associated with an increased risk of gastric cancer". Oncology Letters 15, no. 5 (2018): 7305-7311. https://doi.org/10.3892/ol.2018.8196
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