Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells

  • Authors:
    • Jian Zhang
    • Dong Chen
    • Dian‑Ming Han
    • Yan‑Hao Cheng
    • Chao Dai
    • Xiu‑Jie Wu
    • Feng‑Yuan Che
    • Xue‑Yuan Heng
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China, Department of Clinical College, Binzhou Medical University, Yantai, Shandong 264000, P.R. China, Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6845-6850
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8197
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tannic acid (TA), a natural plant compound, is known to induce the death of cancer cells in various types of cancer. The present study was designed with the aim of exploring the effects of tannic acid in vitro on HS 683, a glioma cell line, and to study the mechanism involved in the induction of cytotoxicity and apoptosis by TA. TA exhibited maximum cytotoxic activity against the Hs 683 cell line. Nuclear morphology, 4',6‑diamidino‑2‑phenylindole staining and annexin V/propidium iodide apoptosis assaying of Hs 683 cells confirmed that cell death was due to the induction of apoptosis by TA. Further mechanistic study of TA on Hs 683 cells revealed that it decreased cell growth with increasing TA concentration, that resulted in the activation of pro‑caspase 3 and caspase 9 and the cleavage of poly (ADP‑ribose) polymerase, implying the induction of apoptosis cascades. Biochemical evidence of apoptosis resulted from the loss of mitochondrial membrane potential and increased intracellular reactive oxygen species production by TA in a dose‑dependent manner. Based on this data, TA may be further investigated as a potential anticancer therapeutic lead.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Fuller GN: The WHO classification of tumours of the central nervous system. 4th edition. Arch Pathol Lab Med. 132:9062008.PubMed/NCBI

4 

Rock K, McArdle O, Forde P, Dunne M, Fitzpatrick D, O'Neill B and Faul C: A clinical review of treatment outcomes in glioblastoma multiforme-the validation in a non-trial population of the results of a randomised Phase III clinical trial: Has a more radical approach improved survival? Br J Radiol. 85:e729–e733. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Singh S, Sharma B, Kanwar SS and Kumar A: Lead phytochemicals for anticancer drug development. Front Plant Sci. 7:16672016. View Article : Google Scholar : PubMed/NCBI

6 

Rahman MA, Amin AR and Shin DM: Chemopreventive potential of natural compounds in head and neck cancer. Nutr Cancer. 62:973–987. 2010. View Article : Google Scholar : PubMed/NCBI

7 

D'Alessandro N, Poma P and Montalto G: Multifactorial nature of hepatocellular carcinoma drug resistance: Could plant polyphenols be helpful? World J Gastroenterol. 13:2037–2043. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Rudolf E, Andelová H and Cervinka M: Polyphenolic compounds in chemoprevention of colon cancer-targets and signaling pathways. Anticancer Agents Med Chem. 7:559–575. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Stevenson DE and Hurst RD: Polyphenolic phytochemicals-just antioxidants or much more? Cell Mol Life Sci. 64:2900–2916. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Fresco P, Borges F, Diniz C and Marques MP: New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 26:747–766. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Romani A, Ieri F, Turchetti B, Mulinacci N, Vincieri FF and Buzzini P: Analysis of condensed and hydrolysable tannins from commercial plant extracts. J Pharm Biomed Anal. 41:415–420. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Gali-Muhtasib HU, Yamout SZ and Sidani MM: Tannins protect against skin tumor promotion induced by ultraviolet-B radiation in hairless mice. Nutr Cancer. 37:73–77. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Sakagami H, Jiang Y, Kusama K, Atsumi T, Ueha T, Toguchi M, Iwakura I, Satoh K, Ito H, Hatano T and Yoshida T: Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines-a possible mechanism. Phytomedicine. 7:39–47. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Pan MH, Lin JH, Lin-Shiau SY and Lin JK: Induction of apoptosis by penta-O-galloyl-beta-D-glucose through activation of caspase-3 in human leukemia HL-60 cells. Eur J Pharmacol. 381:171–183. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Wang CC, Chen LG and Yang LL: Cuphiin D1, the macrocyclic hydrolyzable tannin induced apoptosis in HL-60 cell line. Cancer Lett. 149:77–83. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Yang LL, Lee CY and Yen KY: Induction of apoptosis by hydrolyzable tannins from Eugenia jambos L. on human leukemia cells. Cancer Lett. 157:65–75. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Nam S, Smith DM and Dou QP: Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis. Cancer Epidemiol Biomarkers Prev. 10:1083–8. 2001.PubMed/NCBI

18 

Blacher E, Levy A, Baruch BB, Green KD, Garneau-Tsodikova S, Fridman M and Stein R: Targeting CD38 in the tumor microenvironment: A novel approach to treat glioma. Cancer Cell Microenvironment. 2:22015.

19 

Lavrik IN, Golks A and Krammer PH: Caspases: Pharmacological manipulation of cell death. J Clin Invest. 115:2665–2672. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Sakahira H, Enari M and Nagata S: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:96–99. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Daly JS and Cooney DO: Interference by tannic acid with the effectiveness of activated charcoal in ‘Universal Antidote’. Clin Toxicol. 12:515–522. 1978. View Article : Google Scholar : PubMed/NCBI

22 

Hupkens P, Boxma H and Dokter J: Tannic acid as a topical agent in burns: Historical considerations and implications for new developments. Burns. 21:57–61. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Shi-Tsi S: Use of combined traditional Chinese and Western medicine in the management of burns. Panminerva Med. 25:197–202. 1983.PubMed/NCBI

24 

Mala A and Tulika T: Therapeutic efficacy of Centella asiatica (L.) and Momordica charantia: As traditional medicinal plant. J Plant Sci. 3:1–9. 2015.

25 

Naus PJ, Henson R, Bleeker G, Wehbe H, Meng F and Patel T: Tannic acid synergizes the cytotoxicity of chemotherapeutic drugs in human cholangiocarcinoma by modulating drug efflux pathways. J Hepatol. 46:222–229. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Ramanathan R, Tan CH and Das NP: Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells. Cancer Lett. 62:217–224. 1992. View Article : Google Scholar : PubMed/NCBI

27 

Booth BW, Inskeep BD, Shah H, Park JP, Hay EJ and Burg KJ: Tannic acid preferentially targets estrogen receptor-positive breast cancer. Int J Breast Cancer. 2013:3696092013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Chen D, Han DM, Cheng YH, Dai C, Wu XJ, Che FY and Heng XY: Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells. Oncol Lett 15: 6845-6850, 2018.
APA
Zhang, J., Chen, D., Han, D., Cheng, Y., Dai, C., Wu, X. ... Heng, X. (2018). Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells. Oncology Letters, 15, 6845-6850. https://doi.org/10.3892/ol.2018.8197
MLA
Zhang, J., Chen, D., Han, D., Cheng, Y., Dai, C., Wu, X., Che, F., Heng, X."Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells". Oncology Letters 15.5 (2018): 6845-6850.
Chicago
Zhang, J., Chen, D., Han, D., Cheng, Y., Dai, C., Wu, X., Che, F., Heng, X."Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells". Oncology Letters 15, no. 5 (2018): 6845-6850. https://doi.org/10.3892/ol.2018.8197
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Chen D, Han DM, Cheng YH, Dai C, Wu XJ, Che FY and Heng XY: Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells. Oncol Lett 15: 6845-6850, 2018.
APA
Zhang, J., Chen, D., Han, D., Cheng, Y., Dai, C., Wu, X. ... Heng, X. (2018). Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells. Oncology Letters, 15, 6845-6850. https://doi.org/10.3892/ol.2018.8197
MLA
Zhang, J., Chen, D., Han, D., Cheng, Y., Dai, C., Wu, X., Che, F., Heng, X."Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells". Oncology Letters 15.5 (2018): 6845-6850.
Chicago
Zhang, J., Chen, D., Han, D., Cheng, Y., Dai, C., Wu, X., Che, F., Heng, X."Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells". Oncology Letters 15, no. 5 (2018): 6845-6850. https://doi.org/10.3892/ol.2018.8197
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team