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May-2018 Volume 15 Issue 5

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer

  • Authors:
    • Yuxiu Huang
    • Lihong Chen
    • Aqin Guo
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
  • Pages: 7291-7296
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8200
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Abstract

Homeobox C8 (HOXC8) is a transcription factor that has been reported to regulate numerous genes associated with tumor progression. However, its function in cervical cancer (CC) remains to be elucidated. In the present study, the expression level of HOXC8 was examined in CC tissues and cell lines using reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Additionally, CC cell lines were transfected with small interfering RNAs (siRNAs) to downregulate the expression of HOX8 and assess cell proliferation using Cell Counting Kit‑8. The results demonstrated a significantly increased expression of HOXC8 in CC tissues and cell lines compared with non‑tumor tissues, and a normal cervical cell line, respectively. Additionally, the downregulation of HOXC8, which was achieved by siRNA transfection, significantly inhibited the proliferation rate of CC cell lines. Kaplan‑Meier curves demonstrated that the increased expression of HOXC8 was associated with poor prognosis of patients with CC. Additionally, univariate and multivariate analysis revealed that HOXC8 was a significant and independent predictor for overall survival of patients with CC. In conclusion, the results of the present study suggest that HOXC8 may be involved in the progression of CC and may serve as a therapeutic target for CC.
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1 

Sharma C, Nusri Qel-A, Begum S, Javed E, Rizvi TA and Hussain A: (-)-Epigallocatechin-3-gallate induces apoptosis and inhibits invasion and migration of human cervical cancer cells. Asian Pac J Cancer Prev. 13:4815–4822. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Ye HN, Zhang YY, Geng L and Li ZJ: Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration. Int J Oncol. 46:757–763. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sun Y, Zhang R, Zhou SJ and Ji YQ: Overexpression of Notch1 is associated with the progression of cervical cancer. Oncol Lett. 9:2750–2756. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Cong L, Zhang F and Shang H: Notch1 targeted regulation of mir-224/LRIG2 signaling for the proliferation and apoptosis of cervical cancer cells. Oncol Lett. 13:2304–2308. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Wang W, Li Y, Liu N, Gao Y and Li L: MiR-23b controls ALDH1A1 expression in cervical cancer stem cells. BMC Cancer. 17:2922017. View Article : Google Scholar : PubMed/NCBI

7 

Akam M: Hox and HOM: Homologous gene clusters in insects and vertebrates. Cell. 57:347–349. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Bhatlekar S, Fields JZ and Boman BM: HOX genes and their role in the development of human cancers. J Mol Med (Berl). 92:811–823. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Alvarado-Ruiz L, Martinez-Silva MG, Torres-Reyes LA, Pina-Sanchez P, Ortiz-Lazareno P, Bravo-Cuellar A, Aguilar-Lemarroy A and Jave-Suarez LF: HOXA9 is underexpressed in cervical cancer cells and its restoration decreases proliferation, migration and expression of epithelial-to-mesenchymal transition genes. Asian Pac J Cancer Prev. 17:1037–1047. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Barba-de la Rosa AP, Briones-Cerecero E, Lugo-Melchor O, De León-Rodríguez A, Santos L, Castelo-Ruelas J, Valdivia A, Piña P, Chagolla-López A, Hernandez-Cueto D, et al: Hox B4 as potential marker of non-differentiated cells in human cervical cancer cells. J Cancer Res Clin Oncol. 138:293–300. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Zhai Y, Kuick R, Nan B, Ota I, Weiss SJ, Trimble CL, Fearon ER and Cho KR: Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res. 67:10163–10172. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Vider BZ, Zimber A, Chastre E, Gespach C, Halperin M, Mashiah P, Yaniv A and Gazit A: Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. Biochem Biophys Res Commun. 272:513–518. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Omatu T: Overexpression of human homeobox gene in lung cancer A549 cells results in enhanced motile and invasive properties] Hokkaido Igaku Zasshi. 74:367–376. 1999.(In Japanese).

14 

Javed S and Langley SE: Importance of HOX genes in normal prostate gland formation, prostate cancer development and its early detection. BJU Int. 113:535–540. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Li Y, Chao F, Huang B, Liu D, Kim J and Huang S: HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression. Oncotarget. 5:2596–1607. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Mueller DW and Bosserhoff AK: MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression. Int J Cancer. 129:1064–1074. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Schmittgen Td and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Ruthala K, Gadi J, Lee JY, Yoon H, Chung HJ and Kim MH: Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion. Mol Cells. 32:273–279. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Axlund SD, Lambert JR and Nordeen SK: HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes. Mol Cancer Res. 8:1643–1655. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Lei H, Wang H, Juan AH and Ruddle FH: The identification of Hoxc8 target genes. Proc Natl Acad Sci USA. 102:2420–2424. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M and Huang S: Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis. Cancer Res. 70:7894–7904. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Alami Y, Castronovo V, Belotti D, Flagiello D and Clausse N: HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. Biochem Biophys Res Commun. 257:738–745. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Chen L and Guo A: Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncol Lett 15: 7291-7296, 2018.
APA
Huang, Y., Chen, L., & Guo, A. (2018). Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncology Letters, 15, 7291-7296. https://doi.org/10.3892/ol.2018.8200
MLA
Huang, Y., Chen, L., Guo, A."Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer". Oncology Letters 15.5 (2018): 7291-7296.
Chicago
Huang, Y., Chen, L., Guo, A."Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer". Oncology Letters 15, no. 5 (2018): 7291-7296. https://doi.org/10.3892/ol.2018.8200
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Chen L and Guo A: Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncol Lett 15: 7291-7296, 2018.
APA
Huang, Y., Chen, L., & Guo, A. (2018). Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncology Letters, 15, 7291-7296. https://doi.org/10.3892/ol.2018.8200
MLA
Huang, Y., Chen, L., Guo, A."Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer". Oncology Letters 15.5 (2018): 7291-7296.
Chicago
Huang, Y., Chen, L., Guo, A."Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer". Oncology Letters 15, no. 5 (2018): 7291-7296. https://doi.org/10.3892/ol.2018.8200
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