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Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance

  • Authors:
    • Jingmei Ye
    • Jiani Wang
    • Nana Zhang
    • Yu Liu
    • Li Tan
    • Lihua Xu
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China, Breast Cancer Center, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Pathology, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7182-7190
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    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8202
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Abstract

The aim of the present study was to investigate the expression of transactivation response RNA‑binding protein (TARBP)1 and its clinical significance in human non‑small‑cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) in 10 NSCLC tissues and paired adjacent normal tissues. TARBP1 protein expression was analyzed in 90 paraffin‑embedded NSCLC tissue samples and paired adjacent normal tissues by immunohistochemistry. Statistical analyses were performed to assess the clinicopathological significance of TARBP1 expression. The expression of TARBP1 mRNA was higher in the 10 NSCLC samples than in the paired adjacent non‑tumor tissues (P=0.0017). In the paraffin‑embedded tissue samples, the expression level of TARBP1 was higher in the cancer tissues than in the adjacent non‑cancerous tissues. TARBP1 expression was detected in 76.67% (69/90) of the NSCLC samples and in 22.22% (20/90) of the adjacent normal lung tissues (P<0.001). The expression of TARBP1 was significantly associated with histological grade (P<0.001), clinical stage (P=0.024) and pathological type (P<0.001), along with a decreased overall survival (OS) rate (P<0.001). On multivariate analysis, the expression of TARBP1 was an independent prognostic factor for hazard ratio (OS, 2.729; 95% confidence interval, 1.471‑5.061; P=0.003). TARBP1 is overexpressed in NSCLC, and the expression of TARBP1 is associated with pathological grade, clinical stage and pathological type. Thus, TARBP1 may be an independent prognostic marker in patients with NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Ye J, Wang J, Zhang N, Liu Y, Tan L and Xu L: Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance. Oncol Lett 15: 7182-7190, 2018.
APA
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., & Xu, L. (2018). Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance. Oncology Letters, 15, 7182-7190. https://doi.org/10.3892/ol.2018.8202
MLA
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., Xu, L."Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance". Oncology Letters 15.5 (2018): 7182-7190.
Chicago
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., Xu, L."Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance". Oncology Letters 15, no. 5 (2018): 7182-7190. https://doi.org/10.3892/ol.2018.8202
Copy and paste a formatted citation
x
Spandidos Publications style
Ye J, Wang J, Zhang N, Liu Y, Tan L and Xu L: Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance. Oncol Lett 15: 7182-7190, 2018.
APA
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., & Xu, L. (2018). Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance. Oncology Letters, 15, 7182-7190. https://doi.org/10.3892/ol.2018.8202
MLA
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., Xu, L."Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance". Oncology Letters 15.5 (2018): 7182-7190.
Chicago
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., Xu, L."Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance". Oncology Letters 15, no. 5 (2018): 7182-7190. https://doi.org/10.3892/ol.2018.8202
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