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Article Open Access

IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway

  • Authors:
    • Chao Su
    • Wenchang Wang
    • Cunchuan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Gastrointestinal Surgery, The Municipal Hospital of Weihai, Weihai, Shandong 264200, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7000-7006
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    Published online on: March 12, 2018
       https://doi.org/10.3892/ol.2018.8234
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Abstract

The present study aimed to investigate the association between insulin-like growth factor-1 (IGF-1) and matrix metalloproteinase‑11 (MMP‑11) expression in gastric cancer (GC) and the underlying mechanisms in SGC‑7901 cells. Reverse transcription‑quantitative polymerase chain reaction analysis revealed that the expression of IGF‑1 and MMP‑11 was significantly upregulated in GC tissues compared with normal gastric tissue. Furthermore, IGF‑1 significantly and dose‑dependently promoted MMP‑11. Western blotting revealed that the addition of IGF‑1 to SGC‑7901 cells led to an evident enhancement in signal transducer and activator of transcription 3 (STAT3), IGF‑1R and Janus kinase 1 (JAK1) phosphorylation at 20 and 40 min. A decrease in the extent of the elevated expression of MMP‑11 and the enhanced phosphorylation of STAT3, JAK1 and IGF‑1 receptor (IGF‑1R) induced by IGF‑1 in SGC‑7901 cells were observed following treatment with NT157 (an IGF‑1R inhibitor). Furthermore, piceatannol (a JAK1 inhibitor) or small interfering RNA against STAT3 reduced the extent of the increased expression of MMP‑11 induced by IGF‑1 in SGC‑7901 cells. Piceatannol treatment induced the dose‑dependent decline in the enhancement of STAT3 phosphorylation induced by IGF‑1, indicating that the JAK1/STAT3 pathway may be implicated in the elevated expression of MMP‑11 induced by IGF‑1 in SGC‑7901 cells. Finally, IGF‑1 treatment significantly promoted the proliferation and invasion of SGC‑7901 cells, which was inhibited following NT157, piceatannol or si‑STAT3 treatment. The present study therefore demonstrated that IGF‑1‑induced MMP‑11 may have facilitated the proliferation and invasion of SGC-7901 cells via the JAK1/STAT3 pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Su C, Wang W and Wang C: IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. Oncol Lett 15: 7000-7006, 2018.
APA
Su, C., Wang, W., & Wang, C. (2018). IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. Oncology Letters, 15, 7000-7006. https://doi.org/10.3892/ol.2018.8234
MLA
Su, C., Wang, W., Wang, C."IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway". Oncology Letters 15.5 (2018): 7000-7006.
Chicago
Su, C., Wang, W., Wang, C."IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway". Oncology Letters 15, no. 5 (2018): 7000-7006. https://doi.org/10.3892/ol.2018.8234
Copy and paste a formatted citation
x
Spandidos Publications style
Su C, Wang W and Wang C: IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. Oncol Lett 15: 7000-7006, 2018.
APA
Su, C., Wang, W., & Wang, C. (2018). IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. Oncology Letters, 15, 7000-7006. https://doi.org/10.3892/ol.2018.8234
MLA
Su, C., Wang, W., Wang, C."IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway". Oncology Letters 15.5 (2018): 7000-7006.
Chicago
Su, C., Wang, W., Wang, C."IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway". Oncology Letters 15, no. 5 (2018): 7000-7006. https://doi.org/10.3892/ol.2018.8234
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