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Case Report Open Access

Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report

  • Authors:
    • Huan Liu
    • Juan Cheng
    • Long Zhao
    • Qian Xu
    • Mingming Xue
    • Shuling Zhang
    • Bei Liu
  • View Affiliations / Copyright

    Affiliations: The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Hematology, The First Affiliated Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7132-7138
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    Published online on: March 12, 2018
       https://doi.org/10.3892/ol.2018.8236
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Abstract

The present study describes a patient with high‑risk chronic myelomonocytic leukemia (CMML), for whom decitabine therapy achieved partial remission, prior to a sudden transformation to acute myeloid leukemia (AML) and an inferior outcome. The 53‑year‑old male reported easily bruising for 5 months. Examination indicated a diagnosis of CMML. Chromosome analysis identified a 48, XY, +8, +21 karyotype, classifying the patient as high‑risk, according to a clinical/molecular CPSS (CPSS‑Mol) model. Gene sequencing detected a mutation in DNA methyltransferase 3α, which is relatively rarely identified in CMML and has recently been reported to have an independent prognostic impact on overall survival time. Partial remission was achieved with decitabine treatment, and hematologic improvement was observed subsequent to 2 cycles of treatment. However, a sudden transformation to AML led to fatality of the patient. This case suggests that decitabine may be an effective therapeutic for high‑risk CMML; however, the response may be temporary, and the ultimate outcome may be extremely poor. Therefore, novel treatment strategies of CMML, including combination therapies with decitabine, or targeted drugs, including Janus kinase inhibitors or granulocyte‑macrophage colony stimulating factor monoclonal antibodies, require investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Cheng J, Zhao L, Xu Q, Xue M, Zhang S and Liu B: Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report. Oncol Lett 15: 7132-7138, 2018.
APA
Liu, H., Cheng, J., Zhao, L., Xu, Q., Xue, M., Zhang, S., & Liu, B. (2018). Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report. Oncology Letters, 15, 7132-7138. https://doi.org/10.3892/ol.2018.8236
MLA
Liu, H., Cheng, J., Zhao, L., Xu, Q., Xue, M., Zhang, S., Liu, B."Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report". Oncology Letters 15.5 (2018): 7132-7138.
Chicago
Liu, H., Cheng, J., Zhao, L., Xu, Q., Xue, M., Zhang, S., Liu, B."Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report". Oncology Letters 15, no. 5 (2018): 7132-7138. https://doi.org/10.3892/ol.2018.8236
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Cheng J, Zhao L, Xu Q, Xue M, Zhang S and Liu B: Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report. Oncol Lett 15: 7132-7138, 2018.
APA
Liu, H., Cheng, J., Zhao, L., Xu, Q., Xue, M., Zhang, S., & Liu, B. (2018). Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report. Oncology Letters, 15, 7132-7138. https://doi.org/10.3892/ol.2018.8236
MLA
Liu, H., Cheng, J., Zhao, L., Xu, Q., Xue, M., Zhang, S., Liu, B."Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report". Oncology Letters 15.5 (2018): 7132-7138.
Chicago
Liu, H., Cheng, J., Zhao, L., Xu, Q., Xue, M., Zhang, S., Liu, B."Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report". Oncology Letters 15, no. 5 (2018): 7132-7138. https://doi.org/10.3892/ol.2018.8236
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