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The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer

  • Authors:
    • Liping Li
    • Jie Liu
    • Chunjing Liu
    • Xianghui Lu
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7163-7167
    |
    Published online on: March 12, 2018
       https://doi.org/10.3892/ol.2018.8246
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Abstract

Tumor necrosis factor-α (TNF-α) is closely related to the occurrence of human cancers. Cervical cancer seriously affects female health. Therefore, our study aimed to investigate the correlation between the polymorphism of TNF‑α‑308 gene and susceptibility to cervical cancer. Whole blood was collected from 142 patients with cervical cancer and 150 healthy controls. PCR‑RFLP was used to detect the polymorphism of TNF‑α‑308 and the correlation between polymorphism of TNF‑α‑308 and the susceptibility to cervical cancer was analyzed. The three genotypes of TNF‑α‑308 were GG, GA and AA, and the distributions of genotypes of TNF‑α‑308 were consistent with Hardy‑Weinberg equilibrium in both cervical cancer group and control group. There were no significant differences in genotype and allele frequency between cervical cancer group and healthy control group (P>0.05). A/A genotype increased the risk of cervical cancer by 1.46 times with 95% confidence interval of 0.32-6.67. Different genotypes were not associated with tumor type (P>0.05). Different genotypes are correlated with cervical cancer TNM stages, tumor differentiation and lymph node metastasis. Proportion of GA+AA genotype in TNM stage III+IV group, low differentiation group and lymph node metastasis group were 28.1, 29.0 and 29.8%, respectively, which were significantly higher than those in stage I+II group, moderate/high differentiation group and non‑lymph node metastasis group (P<0.05). The results suggested that TNF‑α‑308 gene polymorphism is associated with the degree of malignancy of cervical cancer. Female patients with A allele have higher malignant degree of cervical cancer.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lo KW, Wong YF, Chan MK, Li JC, Poon JS, Wang VW, Zhu SN, Zhang TM, He ZG, Wu QL, et al: Prevalence of humanpapillomavirus in cervical cancer: A multicenter study in China. Int J Cancer. 100:327–331. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Cornet I, Gheit T, Iannacone MR, Vignat J, Sylla BS, Del Mistro A, Franceschi S, Tommasino M and Clifford GM: HPV16 genetic variation and the development ofcervical cancer worldwide. Br J Cancer. 108:240–244. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Balkwill F: Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev. 13:135–141. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Ding B, Fu S, Wang M, Yue C, Wang W, Zhou D, Zhang Z and Han S: Tumor necrosis factor α-308 G>A polymorphisms and cervical cancer risk: A meta-analysis. Int J Gynecol Cancer. 22:213–219. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Suganuma M, Kurusu M, Suzuki K, Nishizono A, Murakami K, Fujioka T and Fujiki H: New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression. J Cancer Res Clin Oncol. 131:305–313. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Kroeger KM, Carville KS and Abraham LJ: The −308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol Immunol. 34:391–399. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Soto U, Das BC, Lengert M, Finzer P, zur Hausen H and Rösl F: Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-alpha mediated repression of viral transcription and modification of the AP-1 transcription complex. Oncogene. 18:3187–3198. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Kyo S, Inoue M, Hayasaka N, Inoue T, Yutsudo M, Tanizawa O and Hakura A: Regulation of early gene expression of human papillomavirus type 16 by inflammatory cytokines. Virology. 200:130–139. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Roszak A, Misztal M, Sowińska A and Jagodziński PP: TNF-α-308 G/A as a risk marker of cervical cancer progression in the Polish population. Mol Diagn Ther. 19:53–57. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Woodworth CD, McMullin E, Iglesias M and Plowman GD: Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells. Proc Natl Acad Sci USA. 92:2840–2844. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Mocellin S and Nitti D: TNF and cancer: The two sides of the coin. Front Biosci. 13:2774–2783. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Q, Zhao GS, Yuan XL, Li XH, Yang Z, Cui YF, Guan QL, Sun XY, Shen W, Xu TA, et al: Tumor necrosis factor alpha-238G/A polymorphism and risk of breast cancer: An update by meta-analysis. Medicine (Baltimore). 96:e74422017. View Article : Google Scholar : PubMed/NCBI

14 

Banday MZ, Balkhi HM, Hamid Z, Sameer AS, Chowdri NA and Haq E: Tumor necrosis factor-α (TNF-α)-308G/A promoter polymorphism in colorectal cancer in ethnic Kashmiri population -A case control study in a detailed perspective. Meta Gene. 9:128–136. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Wang Q, Zhang C, Walayat S, Chen HW and Wang Y: Association between cytokine gene polymorphisms and cervical cancer in a Chinese population. Eur J Obstet Gynecol Reprod Biol. 158:330–333. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Du LC and Gao R: Role of TNF-α-308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis. Turk J Gastroenterol. 28:272–282. 2017. View Article : Google Scholar : PubMed/NCBI

17 

de Oliveira JG, Rossi AF, Nizato DM, Cadamuro AC, Jorge YC, Valsechi MC, Venâncio LP, Rahal P, Pavarino ÉC, Goloni-Bertollo EM, et al: Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. Tumour Biol. 36:9159–9170. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Li Z, Li SA, Sun Y, Liu Y, Li WL, Yang L, Duan Y, Li J, Guo H, Zou TN, et al: TNF-α −308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China. PLoS One. 12:e01782182017. View Article : Google Scholar : PubMed/NCBI

19 

Sousa H, Oliveira S, Santos AM, Catarino R, Moutinho J and Medeiros R: Tumour necrosis factor alpha 308 G/A is a risk marker for the progression from high-grade lesions to invasive cervical cancer. Tumour Biol. 35:2561–2564. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Barbisan G, Pérez LO, Contreras A and Golijow CD: TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk. Tumour Biol. 33:1549–1556. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Govan VA, Constant D, Hoffman M and Williamson AL: The allelic distribution of −308 tumor necrosis factor-alpha gene polymorphism in South African women with cervical cancer and control women. BMC Cancer. 6:242006. View Article : Google Scholar : PubMed/NCBI

22 

Wang N, Yin D, Zhang S, Wei H, Wang S, Zhang Y, Lu Y, Dai S, Li W, Zhang Q, et al: TNF-alpha rs1800629 polymorphism is not associated with HPV infection or cervical cancer in the Chinese population. PLoS One. 7:e452462012. View Article : Google Scholar : PubMed/NCBI

23 

Kohaar I, Thakur N, Salhan S, Batra S, Singh V, Sharma A, Sodhani P, Das BC, Sarkar DP and Bharadwaj M: TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population. Cell Oncol. 29:249–256. 2007.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Liu J, Liu C and Lu X: The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer. Oncol Lett 15: 7163-7167, 2018.
APA
Li, L., Liu, J., Liu, C., & Lu, X. (2018). The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer. Oncology Letters, 15, 7163-7167. https://doi.org/10.3892/ol.2018.8246
MLA
Li, L., Liu, J., Liu, C., Lu, X."The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer". Oncology Letters 15.5 (2018): 7163-7167.
Chicago
Li, L., Liu, J., Liu, C., Lu, X."The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer". Oncology Letters 15, no. 5 (2018): 7163-7167. https://doi.org/10.3892/ol.2018.8246
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Liu J, Liu C and Lu X: The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer. Oncol Lett 15: 7163-7167, 2018.
APA
Li, L., Liu, J., Liu, C., & Lu, X. (2018). The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer. Oncology Letters, 15, 7163-7167. https://doi.org/10.3892/ol.2018.8246
MLA
Li, L., Liu, J., Liu, C., Lu, X."The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer". Oncology Letters 15.5 (2018): 7163-7167.
Chicago
Li, L., Liu, J., Liu, C., Lu, X."The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer". Oncology Letters 15, no. 5 (2018): 7163-7167. https://doi.org/10.3892/ol.2018.8246
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