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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-2018 Volume 15 Issue 5

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Case Report Open Access

Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report

  • Authors:
    • Tomofumi Naruse
    • Mitsuko Tokuhisa
    • Souichi Yanamoto
    • Yuki Sakamoto
    • Kohei Okuyama
    • Hiroki Tsuchihashi
    • Masahiro Umeda
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oral Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852‑8588, Japan
    Copyright: © Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7158-7162
    |
    Published online on: March 14, 2018
       https://doi.org/10.3892/ol.2018.8261
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Abstract

Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long‑term cetuximab treatment in a 60‑year‑old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N‑cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial‑to‑mesenchymal transition potential.
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Copy and paste a formatted citation
Spandidos Publications style
Naruse T, Tokuhisa M, Yanamoto S, Sakamoto Y, Okuyama K, Tsuchihashi H and Umeda M: Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report. Oncol Lett 15: 7158-7162, 2018.
APA
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., & Umeda, M. (2018). Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report. Oncology Letters, 15, 7158-7162. https://doi.org/10.3892/ol.2018.8261
MLA
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., Umeda, M."Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report". Oncology Letters 15.5 (2018): 7158-7162.
Chicago
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., Umeda, M."Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report". Oncology Letters 15, no. 5 (2018): 7158-7162. https://doi.org/10.3892/ol.2018.8261
Copy and paste a formatted citation
x
Spandidos Publications style
Naruse T, Tokuhisa M, Yanamoto S, Sakamoto Y, Okuyama K, Tsuchihashi H and Umeda M: Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report. Oncol Lett 15: 7158-7162, 2018.
APA
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., & Umeda, M. (2018). Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report. Oncology Letters, 15, 7158-7162. https://doi.org/10.3892/ol.2018.8261
MLA
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., Umeda, M."Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report". Oncology Letters 15.5 (2018): 7158-7162.
Chicago
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., Umeda, M."Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report". Oncology Letters 15, no. 5 (2018): 7158-7162. https://doi.org/10.3892/ol.2018.8261
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