Open Access

Baseline prostate-specific antigen levels following treatment with abiraterone acetate as a prognostic factor in castration-resistant prostate cancer

  • Authors:
    • Tasuku Hiroshige
    • Yoshiro Eguchi
    • Osamu Yoshizumi
    • Katsuaki Chikui
    • Hisaji Kumagai
    • Yoshihiro Kawaguchi
    • Rei Onishi
    • Tokumasa Hayashi
    • Kouta Watanabe
    • Tomotaro Mitani
    • Koujiro Saito
    • Tsukasa Igawa
  • View Affiliations

  • Published online on: March 14, 2018     https://doi.org/10.3892/ol.2018.8263
  • Pages: 6806-6814
  • Copyright: © Hiroshige et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the prognostic factors associated with progression‑free survival (PFS) and overall survival (OS) times in patients with castration-resistant prostate cancer (CRPC) who received treatment with abiraterone acetate (AA) in routine clinical settings. A total of 93 patients treated with AA between September 2014 and February 2017 were selected and their medical records were analyzed retrospectively. The median PFS time of docetaxel (DTX)‑naïve patients was 171 days, and that of post‑DTX patients was 56 days. The OS time of DTX‑naïve patients did not reach the median. The median OS time of post‑DTX patients was 761 days. Multivariate analyses identified baseline prostate‑specific antigen (PSA) level prior to treatment with AA and the PSA response rate as independent prognostic factors for PFS time, and baseline PSA prior to treatment with AA as the only independent prognostic factor for OS time. The results of the present study indicate that the baseline PSA level prior to treatment with AA is a notable prognostic factor in patients with CRPC.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hiroshige T, Eguchi Y, Yoshizumi O, Chikui K, Kumagai H, Kawaguchi Y, Onishi R, Hayashi T, Watanabe K, Mitani T, Mitani T, et al: Baseline prostate-specific antigen levels following treatment with abiraterone acetate as a prognostic factor in castration-resistant prostate cancer. Oncol Lett 15: 6806-6814, 2018
APA
Hiroshige, T., Eguchi, Y., Yoshizumi, O., Chikui, K., Kumagai, H., Kawaguchi, Y. ... Igawa, T. (2018). Baseline prostate-specific antigen levels following treatment with abiraterone acetate as a prognostic factor in castration-resistant prostate cancer. Oncology Letters, 15, 6806-6814. https://doi.org/10.3892/ol.2018.8263
MLA
Hiroshige, T., Eguchi, Y., Yoshizumi, O., Chikui, K., Kumagai, H., Kawaguchi, Y., Onishi, R., Hayashi, T., Watanabe, K., Mitani, T., Saito, K., Igawa, T."Baseline prostate-specific antigen levels following treatment with abiraterone acetate as a prognostic factor in castration-resistant prostate cancer". Oncology Letters 15.5 (2018): 6806-6814.
Chicago
Hiroshige, T., Eguchi, Y., Yoshizumi, O., Chikui, K., Kumagai, H., Kawaguchi, Y., Onishi, R., Hayashi, T., Watanabe, K., Mitani, T., Saito, K., Igawa, T."Baseline prostate-specific antigen levels following treatment with abiraterone acetate as a prognostic factor in castration-resistant prostate cancer". Oncology Letters 15, no. 5 (2018): 6806-6814. https://doi.org/10.3892/ol.2018.8263