Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis

  • Authors:
    • Chung‑Jie Cao
    • Cheng‑Yun Dou
    • Jiayan Lian
    • Zhao‑Sheng Luan
    • Wen Zhou
    • Wenlin Xie
    • Li Chen
    • Kehua Zhou
    • Hong Lai
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Nuclear Medicine, PLA 88 Hospital, Taian, Shandong 271000, P.R. China, Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 8141-8148
    |
    Published online on: March 15, 2018
       https://doi.org/10.3892/ol.2018.8270
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cervical lymph node metastasis (CLNM) is common in differentiated thyroid cancer (DTC). Radioiodine‑131 (131I) treatment is recommended for the removal of residual thyroid tissue following thyroidectomy. To date, the effect of 131I therapy on the outcomes of patients with DTC with CLNM is unclear. The aim of the present study was to evaluate the final outcome of patients with DTC with CLNM according to 131I administration, and to analyze the factors that may affect clinical outcomes. A total of 357 patients with DTC with CLNM were recruited and divided into three groups: Those who received 2, 3 or 4 doses of 131I therapy, respectively. Successful ablation was defined as levels of stimulated serum thyroglobulin <2 ng/ml in the absence of CLNM. The rates of successful ablation were 80.35 (229/285), 76.36 (42/55) and 70.59% (12/17) for patients who received 2, 3 and 4 doses, respectively. The patients with DTC with CLNM who were <45 years old, with tumor sizes <2 cm, solitary nodules and TNM stage I‑II disease exhibited significantly higher rates of successful ablation compared with the patients who were ≥45 years old, with tumor size ≥2 cm, multiple nodules and stage III‑IV disease. Multivariate analyses revealed that tumor size, number of nodules and TNM stage were independent risk factors associated with successful ablation in patients with DTC with CLNM who received 2 doses of 131I therapy. 131I administration is a useful therapy to eradicate cervical lymph node metastasis in patients with DTC, and may be preferentially indicated in patients with DTC with CLNM who are aged <45 years, with tumor sizes <2 cm, solitary nodules and lower TNM stages, in order to control and prevent recurrence and/or metastases.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Mitchell AL, Gandhi A, Scott-Coombes D and Perros P: Management of thyroid cancer: United kingdom national multidisciplinary guidelines. J Laryngol Otol. 130:S150–S160. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Shi RL, Qu N, Yang SW, Ma B, Lu ZW, Wen D, Sun GH, Wang Y and Ji QH: Tumor size interpretation for predicting cervical lymph node metastasis using a differentiated thyroid cancer risk model. Onco Targets Ther. 9:5015–5022. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Wang TS, Dubner S, Sznyter LA and Heller KS: Incidence of metastatic well-differentiated thyroid cancer in cervical lymph nodes. Arch Otolaryngol Head Neck Surg. 130:110–113. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Hay ID, Grant CS, van Heerden JA, Goellner JR, Ebersold JR and Bergstralh EJ: Papillary thyroid microcarcinoma: A study of 535 cases observed in a 50-year period. Surgery. 112:1139–1147. 1992.PubMed/NCBI

6 

Lang BH, Ng SH, Lau LL, Cowling BJ, Wong KP and Wan KY: A systematic review and meta-analysis of prophylactic central neck dissection on short-term locoregional recurrence in papillary thyroid carcinoma after total thyroidectomy. Thyroid. 23:1087–1098. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Hundahl SA, Cady B, Cunningham MP, Mazzaferri E, McKee RF, Rosai J, Shah JP, Fremgen AM, Stewart AK and Hölzer S: Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996. U.S. and German thyroid cancer study group. An American college of surgeons commission on cancer patient care evaluation study. Cancer. 89:202–217. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Ain KB: Radioiodine-remnant ablation in low-risk differentiated thyroid cancer. Pros Endocrine. 50:61–66. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Schlumberger M, Catargi B, Borget I, Deandreis D, Zerdoud S, Bridji B, Bardet S, Leenhardt L, Bastie D, Schvartz C, et al: Strategies of radioiodine ablation in patients with low-risk thyroid cancer. N Engl J Med. 366:1663–1673. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Lee YM, Cho JY, Sung TY, Kim TY, Chung KW, Hong SJ and Yoon JH: Clinicopathological risk factors and biochemical predictors of safe discharge after total thyroidectomy and central compartment node dissection for thyroid cancer: A prospective study. Int J Endocrinol. 2015:2145252015. View Article : Google Scholar : PubMed/NCBI

11 

Jia Q, Meng Z, Tan J, Zhang G, He Y, Sun H, Yu C, Li D, Zheng W, Wang R, et al: Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer. Exp Ther Med. 10:1995–2001. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Hackshaw A, Harmer C, Mallick U, Haq M and Franklyn JA: 131I activity for remnant ablation in patients with differentiated thyroid cancer: A systematic review. J Clin Endocrinol Metab. 92:28–38. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

14 

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, . Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, et al: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 19:1167–1214. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Harding LK: Radiation protection legislation. Eur J Nucl Med. 25:187–191. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Alexander C, Bader JB, Schaefer A, Finke C and Kirsch CM: Intermediate and long-term side effects of high-dose radioiodine therapy for thyroid carcinoma. J Nucl Med. 39:1551–1554. 1998.PubMed/NCBI

17 

Chang H, Yoo RN, Kim SM, Kim BW, Lee YS, Lee SC, Chang HS and Park CS: The clinical significance of the right para-oesophageal lymph nodes in papillary thyroid cancer. Yonsei Med J. 56:1632–1637. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Gulcelik MA, Ozdemir Y, Kadri Colakoglu M, Camlibel M and Alagol H: Prognostic factors determining survival in patients with node positive differentiated thyroid cancer: A retrospective cross-sectional study. Clin Otolaryngol. 37:460–467. 2012. View Article : Google Scholar : PubMed/NCBI

19 

American Thyroid Association Surgery Working Group; American Association of Endocrine Surgeons, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society, . Carty SE, Cooper DS, Doherty GM, Duh QY, Kloos RT, Mandel SJ, et al: Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid. 19:1153–1158. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Bal CS, Kumar A and Pant GS: Radioiodine dose for remnant ablation in differentiated thyroid carcinoma: A randomized clinical trial in 509 patients. J Clin Endocrinol Metab. 89:1666–1673. 2004. View Article : Google Scholar : PubMed/NCBI

21 

M E, l-Refaei S, W Yassin S, Salman K, Al Munshy T, Al-Ezzi M, M Al-Sayed Y and Abd Elkareem Husseni M: Comparison between low and high radioactive iodine (131I) reablation dose in patients with papillary thyroid cancer. Nucl Med Commun. 36:114–119. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Lim YC, Liu L, Chang JW and Koo BS: Lateral lymph node recurrence after total thyroidectomy and central neck dissection in patients with papillary thyroid cancer without clinical evidence of lateral neck metastasis. Oral Oncol. 62:109–113. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Wagieh SM, El-Refaei SM, Salem SS, Al-Shiekh EA, Al-Ghamdy HA and Al-Juhani NR: Impact of histopathology of non-neoplastic thyroid tissue on ablation outcome in patients with papillary thyroid cancer. Nucl Med Commun. 32:597–604. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Pacini F, Schlumberger M, Harmer C, Berg GG, Cohen O, Duntas L, Jamar F, Jarzab B, Limbert E, Lind P, et al: Post-surgical use of radioiodine (131I) in patients with papillary and follicular thyroid cancer and the issue of remnant ablation: A consensus report. Eur J Endocrinol. 153:651–659. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Tsang RW, Brierley JD, Simpson WJ, Panzarella T, Gospodarowicz MK and Sutcliffe SB: The effects of surgery, radioiodine, and external radiation therapy on the clinical outcome of patients with differentiated thyroid carcinoma. Cancer. 82:375–388. 1998. View Article : Google Scholar : PubMed/NCBI

26 

McCowen KD, Adler RA, Ghaed N, Verdon T and Hofeldt FD: Low dose radioiodide thyroid ablation in postsurgical patients with thyroid cancer. Am J Med. 61:52–58. 1976. View Article : Google Scholar : PubMed/NCBI

27 

Prpic M, Dabelic N, Stanicic J, Jukic T, Milosevic M and Kusic Z: Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: A comparison of ablation success with different activities of radioiodine (I-131). Ann Nucl Med. 26:744–751. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Higashi T, Nishii R, Yamada S, Nakamoto Y, Ishizu K, Kawase S, Togashi K, Itasaka S, Hiraoka M, Misaki T and Konishi J: Delayed initial radioactive iodine therapy resulted in poor survival in patients with metastatic differentiated thyroid carcinoma: A retrospective statistical analysis of 198 cases. J Nucl Med. 52:683–689. 2012. View Article : Google Scholar

29 

Tsirona S, Vlassopoulou V, Tzanela M, Rondogianni P, Ioannidis G, Vassilopoulos C, Botoula E, Trivizas P, Datseris I and Tsagarakis S: Impact of early vs late postoperative radioiodine remnant ablation on final outcome in patients with low-risk well-differentiated thyroid cancer. Clin Endocrinol (Oxf). 80:459–463. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cao CJ, Dou CY, Lian J, Luan ZS, Zhou W, Xie W, Chen L, Zhou K and Lai H: Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis. Oncol Lett 15: 8141-8148, 2018.
APA
Cao, C., Dou, C., Lian, J., Luan, Z., Zhou, W., Xie, W. ... Lai, H. (2018). Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis. Oncology Letters, 15, 8141-8148. https://doi.org/10.3892/ol.2018.8270
MLA
Cao, C., Dou, C., Lian, J., Luan, Z., Zhou, W., Xie, W., Chen, L., Zhou, K., Lai, H."Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis". Oncology Letters 15.5 (2018): 8141-8148.
Chicago
Cao, C., Dou, C., Lian, J., Luan, Z., Zhou, W., Xie, W., Chen, L., Zhou, K., Lai, H."Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis". Oncology Letters 15, no. 5 (2018): 8141-8148. https://doi.org/10.3892/ol.2018.8270
Copy and paste a formatted citation
x
Spandidos Publications style
Cao CJ, Dou CY, Lian J, Luan ZS, Zhou W, Xie W, Chen L, Zhou K and Lai H: Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis. Oncol Lett 15: 8141-8148, 2018.
APA
Cao, C., Dou, C., Lian, J., Luan, Z., Zhou, W., Xie, W. ... Lai, H. (2018). Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis. Oncology Letters, 15, 8141-8148. https://doi.org/10.3892/ol.2018.8270
MLA
Cao, C., Dou, C., Lian, J., Luan, Z., Zhou, W., Xie, W., Chen, L., Zhou, K., Lai, H."Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis". Oncology Letters 15.5 (2018): 8141-8148.
Chicago
Cao, C., Dou, C., Lian, J., Luan, Z., Zhou, W., Xie, W., Chen, L., Zhou, K., Lai, H."Clinical outcomes and associated factors of radioiodine-131 treatment in differentiated thyroid cancer with cervical lymph node metastasis". Oncology Letters 15, no. 5 (2018): 8141-8148. https://doi.org/10.3892/ol.2018.8270
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team