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Article

Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma

  • Authors:
    • Dongyun Xu
    • Yuqing Miao
    • Xiaoqiang Gu
    • Jiejun Wang
    • Guanzhen Yu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Huaihai Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221003, P.R. China, Department of Oncology, Changzheng Hospital, Shanghai 200070, P.R. China, Department of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
  • Pages: 8095-8101
    |
    Published online on: March 15, 2018
       https://doi.org/10.3892/ol.2018.8278
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Abstract

The inorganic pyrophosphatase gene (PPA1) encodes inorganic pyrophosphatase, an enzyme that catalyzes the hydrolysis of inorganic pyrophosphate to orthophosphate, and has been revealed to be dysregulated in several types of human cancer. However, the role of PPA1 in intrahepatic cholangiocarcinoma (ICC) has not yet been determined. The present study detected PPA1 expression and investigated its clinical significance in ICC. Tissue microarray blocks containing 93 ICC specimens were constructed. The protein expression of PPA1 in these specimens was detected by immunohistochemistry. PPA1 was overexpressed in 49.5% of the ICC specimens and was significantly associated with large tumor size, positive margins, T stage, lymph nodal metastases, poorly differentiated tumors and advanced disease stage. Furthermore, PPA1 expression was an indicator of future recurrence and poor survival in patients with ICC. Increased expression of PPA1 is a common event in human ICC and is significantly associated with a poor outcome in patients with ICC, suggesting a potential role for PPA1 in the development and progression of ICC.
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1 

Razumilava N and Gores GJ: Cholangiocarcinoma. Lancet. 383:2168–2179. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Nehls O, Gregor M and Klump B: Serum and bile markers for cholangiocarcinoma. Semin Liver Dis. 24:139–154. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Patel T: Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 33:1353–1357. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Patel T: Worldwide trends in mortality from biliary tract malignancies. BMC Cancer. 2:102002. View Article : Google Scholar : PubMed/NCBI

5 

Poultsides GA, Zhu AX, Choti MA and Pawlik TM: Intrahepatic cholangiocarcinoma. Surg Clin North Am. 90:817–837. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Cardinale V, Carpino G, Reid L, Gaudio E and Alvaro D: Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity. World J Gastrointest Oncol. 4:94–102. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Harrison LE, Fong Y, Klimstra DS, Zee SY and Blumgart LH: Surgical treatment of 32 patients with peripheral intrahepatic cholangiocarcinoma. Br J Surg. 85:1068–1070. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Yamamoto M, Takasaki K, Yoshikawa T, Ueno K and Nakano M: Does gross appearance indicate prognosis in intrahepatic cholangiocarcinoma? J Surg Oncol. 69:162–167. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Nakagohri T, Kinoshita T, Konishi M, Takahashi S and Gotohda N: Surgical outcome and prognostic factors in intrahepatic cholangiocarcinoma. World J Surg. 32:2675–2680. 2008. View Article : Google Scholar : PubMed/NCBI

10 

El-Serag HB, Engels EA, Landgren O, Chiao E, Henderson L, Amaratunge HC and Giordano TP: Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. Hepatology. 49:116–123. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Welzel TM, Graubard BI, El-Serag HB, Shaib YH, Hsing AW, Davila JA and McGlynn KA: Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: A population-based case-control study. Clin Gastroenterol Hepatol. 5:1221–1228. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Zhang F, Li L, Yang X, Wang B, Zhao J, Lu S and Yu X: Expression and activation of EGFR and STAT3 during the multistage carcinogenesis of intrahepatic cholangiocarcinoma induced by 3′-methyl-4 dimethylaminoazobenzene in rats. J Toxicol Pathol. 28:79–87. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Chen Y, Ma L, He Q, Zhang S, Zhang C and Jia W: TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma. Biol Res. 48:262015. View Article : Google Scholar : PubMed/NCBI

14 

Tian X, Wang Q, Li Y, Hu J, Wu L, Ding Q and Zhang C: The expression of S100A4 protein in human intrahepatic cholangiocarcinoma: Clinicopathologic significance and prognostic value. Pathol Oncol Res. 21:195–201. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Baykov AA, Cooperman BS, Goldman A and Lahti R: Cytoplasmic inorganic pyrophosphatase. Prog Mol Subcell Biol. 23:127–150. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Islam MK, Miyoshi T, Yamada M and Tsuji N: Pyrophosphatase of the roundworm Ascaris suum plays an essential role in the worm's molting and development. Infect Immun. 73:1995–2004. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Chen J, Brevet A, Fromant M, Lévêque F, Schmitter JM, Blanquet S and Plateau P: Pyrophosphatase is essential for growth of Escherichia coli. J Bacteriol. 172:5686–5689. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Kharbhih WJ and Sharma R: Age-dependent increased expression and activity of inorganic pyrophosphatase in the liver of male mice and its further enhancement with short- and long-term dietary restriction. Biogerontology. 15:81–86. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Panda H, Pandey RS, Debata PR and Supakar PC: Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene. Biogerontology. 8:517–525. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Chen G, Gharib TG, Huang CC, Thomas DG, Shedden KA, Taylor JM, Kardia SL, Misek DE, Giordano TJ, Iannettoni MD, et al: Proteomic analysis of lung adenocarcinoma: Identification of a highly expressed set of proteins in tumors. Clin Cancer Res. 8:2298–2305. 2002.PubMed/NCBI

21 

Hamler RL, Zhu K, Buchanan NS, Kreunin P, Kachman MT, Miller FR and Lubman DM: A two-dimensional liquid-phase separation method coupled with mass spectrometry for proteomic studies of breast cancer and biomarker identification. Proteomics. 4:562–577. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Chahed K, Kabbage M, Ehret-Sabatier L, Lemaitre-Guillier C, Remadi S, Hoebeke J and Chouchane L: Expression of fibrinogen E-fragment and fibrin E-fragment is inhibited in the human infiltrating ductal carcinoma of the breast: The two-dimensional electrophoresis and MALDI-TOF-mass spectrometry analyses. Int J Oncol. 27:1425–1431. 2005.PubMed/NCBI

23 

Megger DA, Bracht T, Kohl M, Ahrens M, Naboulsi W, Weber F, Hoffmann AC, Stephan C, Kuhlmann K, Eisenacher M, et al: Proteomic differences between hepatocellular carcinoma and nontumorous liver tissue investigated by a combined gel-based and label-free quantitative proteomics study. Mol Cell Proteomics. 12:2006–2020. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Tomonaga T, Matsushita K, Yamaguchi S, Oh-Ishi M, Kodera Y, Maeda T, Shimada H, Ochiai T and Nomura F: Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis. Clin Cancer Res. 10:2007–2014. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Yu WL, Cong WM, Zhang Y, Chen Y, Wang F and Yu G: Overexpression of ATA1/SLC38A1 predicts future recurrence and death in Chinese patients with hilar cholangiocarcinoma. J Surg Res. 171:663–668. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Chen Y, Cha Z, Fang W, Qian B, Yu W, Li W, Yu G and Gao Y: The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma. Oncotarget. 6:20419–20433. 2015.PubMed/NCBI

27 

Yu G, Yu W, Jin G, Xu D, Chen Y, Xia T, Yu A, Fang W, Zhang X, Li Z and Xie K: PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma. Mol Cancer. 14:1932015. View Article : Google Scholar : PubMed/NCBI

28 

Kim Y, Moris DP, Zhang XF, Bagante F, Spolverato G, Schmidt C, Dilhoff M and Pawlik TM: Evaluation of the 8th edition American joint commission on cancer (AJCC) staging system for patients with intrahepatic cholangiocarcinoma: A surveillance, epidemiology, and end results (SEER) analysis. J Surg Oncol. 116:643–650. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Jeong SH, Ko GH, Cho YH, Lee YJ, Cho BI, Ha WS, Choi SK, Kim JW, Lee CW, Heo YS, et al: Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer. Tumour Biol. 33:1889–1898. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Sempoux C, Jibara G, Ward SC, Fan C, Qin L, Roayaie S, Fiel MI, Schwartz M and Thung SN: Intrahepatic cholangiocarcinoma: New insights in pathology. Semin Liver Dis. 31:49–60. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hyder O, Marques H, Pulitano C, Marsh JW, Alexandrescu S, Bauer TW, Gamblin TC, Sotiropoulos GC, Paul A, Barroso E, et al: A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: An Eastern and Western experience. JAMA Surg. 149:432–438. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Ribero D, Pinna AD, Guglielmi A, Ponti A, Nuzzo G, Giulini SM, Aldrighetti L, Calise F, Gerunda GE, Tomatis M, et al: Surgical approach for long-term survival of patients with intrahepatic cholangiocarcinoma: A multi-institutional analysis of 434 patients. Arch Surg. 147:1107–1113. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Li YY, Li H, Lv P, Liu G, Li XR, Tian BN and Chen DJ: Prognostic value of cirrhosis for intrahepatic cholangiocarcinoma after surgical treatment. J Gastrointest Surg. 15:608–613. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Mishra DR, Chaudhary S, Krishna BM and Mishra SK: Identification of critical elements for regulation of inorganic pyrophosphatase (PPA1) in MCF7 breast cancer cells. PLoS One. 10:e01248642015. View Article : Google Scholar : PubMed/NCBI

35 

Thoma I, Loeffler C, Sinha AK, Gupta M, Krischke M, Steffan B, Roitsch T and Mueller MJ: Cyclopentenone isoprostanes induced by reactive oxygen species trigger defense gene activation and phytoalexin accumulation in plants. Plant J. 34:363–375. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu D, Miao Y, Gu X, Wang J and Yu G: Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma. Oncol Lett 15: 8095-8101, 2018.
APA
Xu, D., Miao, Y., Gu, X., Wang, J., & Yu, G. (2018). Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma. Oncology Letters, 15, 8095-8101. https://doi.org/10.3892/ol.2018.8278
MLA
Xu, D., Miao, Y., Gu, X., Wang, J., Yu, G."Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma". Oncology Letters 15.5 (2018): 8095-8101.
Chicago
Xu, D., Miao, Y., Gu, X., Wang, J., Yu, G."Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma". Oncology Letters 15, no. 5 (2018): 8095-8101. https://doi.org/10.3892/ol.2018.8278
Copy and paste a formatted citation
x
Spandidos Publications style
Xu D, Miao Y, Gu X, Wang J and Yu G: Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma. Oncol Lett 15: 8095-8101, 2018.
APA
Xu, D., Miao, Y., Gu, X., Wang, J., & Yu, G. (2018). Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma. Oncology Letters, 15, 8095-8101. https://doi.org/10.3892/ol.2018.8278
MLA
Xu, D., Miao, Y., Gu, X., Wang, J., Yu, G."Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma". Oncology Letters 15.5 (2018): 8095-8101.
Chicago
Xu, D., Miao, Y., Gu, X., Wang, J., Yu, G."Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma". Oncology Letters 15, no. 5 (2018): 8095-8101. https://doi.org/10.3892/ol.2018.8278
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