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Article Open Access

Association between ovarian cancer and advanced endometriosis

  • Authors:
    • Michail Matalliotakis
    • Charoula Matalliotaki
    • George N. Goulielmos
    • Evridiki Patelarou
    • Maria Tzardi
    • Demetrios A. Spandidos
    • Aydin Arici
    • Ioannis Matalliotakis
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Crete, Greece, School of Health Sciences and Welfare, Technological Educational Institute of Crete, 71004 Heraklion, Crete, Greece, Department of Histopathology, University Hospital of Heraklion, Faculty of Medicine, 71110 Heraklion, Crete, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Copyright: © Matalliotakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7689-7692
    |
    Published online on: March 16, 2018
       https://doi.org/10.3892/ol.2018.8287
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Abstract

We retrospectively analyzed clinicopathological data in two different countries over the past years on the association between ovarian endometriosis and ovarian carcinoma. Medical and pathological reports were evaluated from 1,000 patients with endometriosis from two different geographical areas. The prevalence and women characteristics of cases were analyzed. Endometriosis‑associated ovarian cancer was present in 20 (2%) cases, among the study subjects. The observed prevalence was 12 (60%) for endometrioid carcinoma, 4 (20%) for clear cell ovarian carcinoma, 2 (10%) for serous and 2 (10%) for mucinous adenocarcinoma. A higher proportion of endometrioid carcinoma cases were noted in comparison with other types (P<0.001). We found only 3/20 (15%) postmenopausal cases. In all cases, we reported advanced stage of endometriosis (stage III or IV). Left‑sided endometrioid carcinoma were notably more common than right‑sided ones (P<0.001). In the majority of cases, malignant transformation of endometriosis was observed in endometrioid carcinoma or clear cell carcinoma of the ovary. Further research is required to establish the relationship between endometriosis and ovarian cancer.
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1 

Vercellini P, Scarfone G, Bolis G, Stellato G, Carinelli S and Crosignani PG: Site of origin of epithelial ovarian cancer: The endometriosis connection. BJOG. 107:1155–1157. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Sampson JA: Endometrial carcinoma of the ovary, arising in endometrial tissue in that organ. Arch Surg. 10:1–72. 1925. View Article : Google Scholar

3 

Vaughan S, Coward JI, Bast RC Jr, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, et al: Rethinking ovarian cancer: Recommendations for improving outcomes. Nat Rev Cancer. 11:719–725. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Guo SW: Endometriosis and ovarian cancer: Potential benefits and harms of screening and risk-reducing surgery. Fertil Steril. 104:813–830. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Erzen M, Rakar S, Klancnik B and Syrjänen K: Endometriosis-associated ovarian carcinoma (EAOC): An entity distinct from other ovarian carcinomas as suggested by a nested case-control study. Gynecol Oncol. 83:100–108. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Kumar S, Munkarah A, Arabi H, Bandyopadhyay S, Semaan A, Hayek K, Garg G, Morris R and Ali-Fehmi R: Prognostic analysis of ovarian cancer associated with endometriosis. Am J Obstet Gynecol. 204:63.e1–63.e7. 2011. View Article : Google Scholar

8 

Birrer MJ: The origin of ovarian cancer - Is it getting clearer? N Engl J Med. 363:1574–1575. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Kappou D, Matalliotakis M, Sifakis S, Ziogos E and Matalliotakis I: The association of endometriosis to various types of malignancies: A comprehensive review of current knowledge and future directionsNew Developments in Endometriosis. Matalliotakis I and Arici A: CreateSpace; pp. 416–456. 2011

10 

Wilbur MA, Shih IM, Segars JH and Fader AN: Cancer implications for patients with endometriosis. Semin Reprod Med. 35:110–116. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Greene AD, Lang SA, Kendziorski JA, Sroga-Rios JM, Herzog TJ and Burns KA: Endometriosis: Where are we and where are we going? Reproduction. 152:R63–R78. 2016. View Article : Google Scholar : PubMed/NCBI

12 

American Fertility Society: Revised American Fertility Society classification of endometriosis: 1985. Fertil Steril. 43:351–352. 1985. View Article : Google Scholar : PubMed/NCBI

13 

Creasman WT: Announcement, FIGO stages: 1988 revisions. Gynecol Oncol. 35:125–127. 1989.

14 

Prefumo F, Todeschini F, Fulcheri E and Venturini PL: Epithelial abnormalities in cystic ovarian endometriosis. Gynecol Oncol. 84:280–284. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE and Westhoff CL: Ovarian cancer risk associated with varying causes of infertility. Fertil Steril. 82:405–414. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Brinton LA, Westhoff CL, Scoccia B, Lamb EJ, Althuis MD, Mabie JE and Moghissi KSP: Causes of infertility as predictors of subsequent cancer risk. Epidemiology. 16:500–507. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Melin A, Sparén P, Persson I and Bergqvist A: Endometriosis and the risk of cancer with special emphasis on ovarian cancer. Hum Reprod. 21:1237–1242. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Sato N, Tsunoda H, Nishida M, Morishita Y, Takimoto Y, Kubo T and Noguchi M: Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: Possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Cancer Res. 60:7052–7056. 2000.PubMed/NCBI

19 

Singer G, Kurman RJ, Chang H-W, Cho SK and Shih IeM: Diverse tumorigenic pathways in ovarian serous carcinoma. Am J Pathol. 160:1223–1228. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Levanon K, Crum C and Drapkin R: New insights into the pathogenesis of serous ovarian cancer and its clinical impact. J Clin Oncol. 26:5284–5293. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, Senz J, McConechy MK, Anglesio MS, Kalloger SE, et al: ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med. 363:1532–1543. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Lee AW, Templeman C, Stram DA, Beesley J, Tyrer J, Berchuck A, Pharoah PP, Chenevix-Trench G, Pearce CL and Ness RB: Ovarian Cancer Association Consortium: Evidence of a genetic link between endometriosis and ovarian cancer. Fertil Steril. 105(35–43): e1–10. 2016.PubMed/NCBI

23 

Burghaus S, Fasching PA, Häberle L, Rübner M, Büchner K, Blum S, Engel A, Ekici AB, Hartmann A, Hein A, et al: Genetic risk factors for ovarian cancer and their role for endometriosis risk. Gynecol Oncol. 145:142–147. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Lu Y, Cuellar-Partida G, Painter JN, Nyholt DR, Morris AP, Fasching PA, Hein A, Burghaus S, Beckmann MW, Lambrechts D, et al: Australian Ovarian Cancer Study; International Endogene Consortium (IEC): Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. Hum Mol Genet. 24:5955–5964. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Matalliotakis I, Mahutte NG, Koukoura O and Arici A: Endometriosis associated with stage IA clear cell ovarian carcinoma in a woman with IVF-ET treatments in the Yale Series. Arch Gynecol Obstet. 274:184–186. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Matalliotakis IM, Cakmak H, Krasonikolakis GD, Dermitzaki D, Fragouli Y, Vlastos G and Arici A: Endometriosis related to family history of malignancies in the Yale series. Surg Oncol. 19:33–37. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Jimbo H, Yoshikawa H, Onda T, Yasugi T, Sakamoto A and Taketani Y: Prevalence of ovarian endometriosis in epithelial ovarian cancer. Int J Gynaecol Obstet. 59:245–250. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Ness RB: Endometriosis and ovarian cancer: Thoughts on shared pathophysiology. Am J Obstet Gynecol. 189:280–294. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Matalliotakis M, Matalliotaki C, Goulielmos GN, Patelarou E, Tzardi M, Spandidos DA, Arici A and Matalliotakis I: Association between ovarian cancer and advanced endometriosis. Oncol Lett 15: 7689-7692, 2018.
APA
Matalliotakis, M., Matalliotaki, C., Goulielmos, G.N., Patelarou, E., Tzardi, M., Spandidos, D.A. ... Matalliotakis, I. (2018). Association between ovarian cancer and advanced endometriosis. Oncology Letters, 15, 7689-7692. https://doi.org/10.3892/ol.2018.8287
MLA
Matalliotakis, M., Matalliotaki, C., Goulielmos, G. N., Patelarou, E., Tzardi, M., Spandidos, D. A., Arici, A., Matalliotakis, I."Association between ovarian cancer and advanced endometriosis". Oncology Letters 15.5 (2018): 7689-7692.
Chicago
Matalliotakis, M., Matalliotaki, C., Goulielmos, G. N., Patelarou, E., Tzardi, M., Spandidos, D. A., Arici, A., Matalliotakis, I."Association between ovarian cancer and advanced endometriosis". Oncology Letters 15, no. 5 (2018): 7689-7692. https://doi.org/10.3892/ol.2018.8287
Copy and paste a formatted citation
x
Spandidos Publications style
Matalliotakis M, Matalliotaki C, Goulielmos GN, Patelarou E, Tzardi M, Spandidos DA, Arici A and Matalliotakis I: Association between ovarian cancer and advanced endometriosis. Oncol Lett 15: 7689-7692, 2018.
APA
Matalliotakis, M., Matalliotaki, C., Goulielmos, G.N., Patelarou, E., Tzardi, M., Spandidos, D.A. ... Matalliotakis, I. (2018). Association between ovarian cancer and advanced endometriosis. Oncology Letters, 15, 7689-7692. https://doi.org/10.3892/ol.2018.8287
MLA
Matalliotakis, M., Matalliotaki, C., Goulielmos, G. N., Patelarou, E., Tzardi, M., Spandidos, D. A., Arici, A., Matalliotakis, I."Association between ovarian cancer and advanced endometriosis". Oncology Letters 15.5 (2018): 7689-7692.
Chicago
Matalliotakis, M., Matalliotaki, C., Goulielmos, G. N., Patelarou, E., Tzardi, M., Spandidos, D. A., Arici, A., Matalliotakis, I."Association between ovarian cancer and advanced endometriosis". Oncology Letters 15, no. 5 (2018): 7689-7692. https://doi.org/10.3892/ol.2018.8287
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