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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Case Report

Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature

  • Authors:
    • Yanan Li
    • Xiaorui Fu
    • Jingjing Wu
    • Chang Yu
    • Zhaoming Li
    • Zhenchang Sun
    • Jiaqin Yan
    • Feifei Nan
    • Xundong Zhang
    • Ling Li
    • Xin Li
    • Lei Zhang
    • Wencai Li
    • Guannan Wang
    • Mingzhi Zhang
  • View Affiliations / Copyright

    Affiliations: Lymphoma Diagnosis and Treatment Center, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 8034-8038
    |
    Published online on: March 16, 2018
       https://doi.org/10.3892/ol.2018.8288
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Abstract

Extranodal natural killer/T-cell lymphoma (NKTL), nasal-type is one of the most aggressive lymphoid malignancies and is characterized by an extremely poor survival outcome. The present study reports the case of a 39‑year‑old Chinese male with history of extranodal NKTL who presented with a painless indurated mass in the glans penis. The results of an incisional biopsy revealed atypical cells that were positive for CD3, CD56, T‑cell‑restricted intracellular antigen‑1, granzyme B and Epstein‑Barr virus‑encoded RNA, and negative for CD20. A diagnosis of metastatic NKTL was determined. The patient was treated with systemic chemotherapy consisting of cisplatin, dexamethasone, gemcitabine and pegaspargase, which resulted in remission and regression of the mass. In addition, a review of the literature was performed, and the data for 13 cases of non‑B‑cell penile lymphoma, including the present case, are presented. To the best of our knowledge, this is first review of this entity.
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1 

Haverkos BM, Pan Z, Gru AA, Freud AG, Rabinovitch R, Xu-Welliver M, Otto B, Barrionuevo C, Baiocchi RA, Rochford R and Porcu P: Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT): An update on epidemiology, clinical presentation and natural history in North American and European cases. Curr Hematol Malig Rep. 11:514–527. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Suzuki R: Pathogenesis and treatment of extranodal natural killer/T-cell lymphoma. Semin Hematol. 51:42–51. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Au WY, Weisenburger DD, Intragumtornchai T, Nakamura S, Kim WS, Sng I, Vose J, Armitage JO and Liang R: International Peripheral T-Cell Lymphoma Project: Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: A study of 136 cases from the international peripheral t-cell lymphoma project. Blood. 113:3931–3937. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Baldur-Felskov B, Hannibal CG, Munk C and Kjaer SK: Increased incidence of penile cancer and high-grade penile intraepithelial neoplasia in denmark 1978–2008: A nationwide population-based study. Cancer Causes Control. 23:273–280. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Barnholtz-Sloan JS, Maldonado JL, Pow-sang J, Giuliano AR and Guiliano AR: Incidence trends in primary malignant penile cancer. Urol Oncol. 25:361–367. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Lin DW, Thorning DR and Krieger JN: Primary penile lymphoma: Diagnostic difficulties and management options. Urology. 54:3661999. View Article : Google Scholar : PubMed/NCBI

7 

Lan SK, Lin CW, Ho HC, Lee MS, Tzeng JE and Su YC: Penile metastasis secondary to nasal NK/T-cell lymphoma. Urology. 72:1014–1015. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC, Rosenberg SA, Coltman CA and Tubiana M: Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting. J Clin Oncol. 7:1630–1636. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Lee J, Suh C, Park YH, Ko YH, Bang SM, Lee JH, Lee DH, Huh J, Oh SY, Kwon HC, et al: Extranodal natural killer T-cell lymphoma, nasal-type: A prognostic model from a retrospective multicenter study. J Clin Oncol. 24:612–618. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Sun J, Medeiros LJ, Lin P, Lu G, Bueso-Ramos CE and You MJ: Plasmablastic lymphoma involving the penis: A previously unreported location of a case with aberrant CD3 expression. Pathology. 43:54–57. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Yao HJ, Ying J, Wang Z, Yao DH, Ren XM and Bao YY: One case report of primary penile malignant lymphoma (with a review of 24 case reports). Zhonghua Nan Ke Xue. 12:520–524. 2006.PubMed/NCBI

12 

Terada T, Shirakashi Y and Sugiura M: T-cell lymphoma of the penis as the first manifestation of adult T-cell lymphoma/leukemia. Int J Dermatol. 51:973–975. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Li YL, Wang QZ, Ding GF, Li LX, Ni Z and Wang XM: Primary non-Hodgkin's lymphoma of the testis and penis: Clinical analysis of 5 cases. Zhonghua Nan Ke Xue. 17:254–256. 2011.(In Chinese). PubMed/NCBI

14 

Zhou ZL, Wang CY, Xu ZS and Zheng BZ: Primary cutaneous T-cell lymphoma of the penis complicated by Fournier gangrene: A case report. Zhonghua Nan Ke Xue. 14:542–544. 2008.PubMed/NCBI

15 

Shi YL, Yin HL, Zhou XJ, Zhou HB and Lu ZF: Primary peripheral T-cell lymphoma of the penis: A case report and review of the literature. Zhonghua Nan Ke Xue. 14:1003–1006. 2008.(In Chinese). PubMed/NCBI

16 

Wang HT, Lo YS and Huang JK: Primary lymphoma of the penis. J Chin Med Assoc. 66:379–381. 2003.PubMed/NCBI

17 

Tomb RR, Stephan F, Klein-Tomb L, Chahine G and Grosshans E: Recurrent primary CD30+ lymphoma of the penis. Br J Dermatol. 149:903–905. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Thorns C, Urban H, Remmler K, Dietel A, Lange K and Merz H: Primary cutaneous T-cell lymphoma of the penis. Histopathology. 42:513–514. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Pomara G, Cuttano MG, Tripodo C, Carlino F and Selli C: Primary T-cell rich B-cell lymphoma of the penis: A first case. BJU Int. 91:8892003. View Article : Google Scholar : PubMed/NCBI

20 

Allen DC and Walsh MY: Malignant lymphoma of the scrotum and Wegener's granulomatosis of the penis-genital presentation of systemic disease. Ulster Med J. 65:169–172. 1996.PubMed/NCBI

21 

Yanagi H, Nakamura Y, Takagi D and Kubota K: Extranodal natural killer/T-cell lymphoma: A diagnostic dilemma. Rhinology. 50:325–331. 2012.PubMed/NCBI

22 

Zhou Z, Li X, Chen C, Li X, Zhang L, Li L, Wang X, Ma W, Fu X, Wu J, et al: Effectiveness of gemcitabine, pegaspargase, cisplatin and dexamethasone (DDGP) combination chemotherapy in the treatment of relapsed/refractory extranodal NK/T cell lymphoma: A retrospective study of 17 patients. Ann Hematol. 93:1889–1894. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Wen JY, Li M, Li X, Chen J, Lin Q, Ma XK, Dong M, Wei L, Chen ZH and Wu XY: Efficacy and tolerance of pegaspargase-based chemotherapy in patients with nasal-type extranodal NK/T-cell lymphoma: A pilot study. Asian Pac J Cancer Prev. 15:6275–6281. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Fu X, Wu J, Yu C, Li Z, Sun Z, Yan J, Nan F, Zhang X, Li L, Li L, et al: Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature. Oncol Lett 15: 8034-8038, 2018.
APA
Li, Y., Fu, X., Wu, J., Yu, C., Li, Z., Sun, Z. ... Zhang, M. (2018). Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature. Oncology Letters, 15, 8034-8038. https://doi.org/10.3892/ol.2018.8288
MLA
Li, Y., Fu, X., Wu, J., Yu, C., Li, Z., Sun, Z., Yan, J., Nan, F., Zhang, X., Li, L., Li, X., Zhang, L., Li, W., Wang, G., Zhang, M."Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature". Oncology Letters 15.5 (2018): 8034-8038.
Chicago
Li, Y., Fu, X., Wu, J., Yu, C., Li, Z., Sun, Z., Yan, J., Nan, F., Zhang, X., Li, L., Li, X., Zhang, L., Li, W., Wang, G., Zhang, M."Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature". Oncology Letters 15, no. 5 (2018): 8034-8038. https://doi.org/10.3892/ol.2018.8288
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Fu X, Wu J, Yu C, Li Z, Sun Z, Yan J, Nan F, Zhang X, Li L, Li L, et al: Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature. Oncol Lett 15: 8034-8038, 2018.
APA
Li, Y., Fu, X., Wu, J., Yu, C., Li, Z., Sun, Z. ... Zhang, M. (2018). Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature. Oncology Letters, 15, 8034-8038. https://doi.org/10.3892/ol.2018.8288
MLA
Li, Y., Fu, X., Wu, J., Yu, C., Li, Z., Sun, Z., Yan, J., Nan, F., Zhang, X., Li, L., Li, X., Zhang, L., Li, W., Wang, G., Zhang, M."Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature". Oncology Letters 15.5 (2018): 8034-8038.
Chicago
Li, Y., Fu, X., Wu, J., Yu, C., Li, Z., Sun, Z., Yan, J., Nan, F., Zhang, X., Li, L., Li, X., Zhang, L., Li, W., Wang, G., Zhang, M."Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature". Oncology Letters 15, no. 5 (2018): 8034-8038. https://doi.org/10.3892/ol.2018.8288
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