Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature

Li,Yanan; Fu,Xiaorui; Wu,Jingjing; Yu,Chang; Li,Zhaoming; Sun,Zhenchang; Yan,Jiaqin; Nan,Feifei; Zhang,Xundong; Li,Ling; Li,Xin; Zhang,Lei; Li,Wencai; Wang,Guannan; Zhang,Mingzhi

doi:10.3892/ol.2018.8288

Penile metastasis secondary to nasal-type extranodal natural killer/T-cell lymphoma: A case report and review of the literature

Authors:
- Yanan Li
- Xiaorui Fu
- Jingjing Wu
- Chang Yu
- Zhaoming Li
- Zhenchang Sun
- Jiaqin Yan
- Feifei Nan
- Xundong Zhang
- Ling Li
- Xin Li
- Lei Zhang
- Wencai Li
- Guannan Wang
- Mingzhi Zhang
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Affiliations: Lymphoma Diagnosis and Treatment Center, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: March 16, 2018 https://doi.org/10.3892/ol.2018.8288
Pages: 8034-8038

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Abstract

Extranodal natural killer/T-cell lymphoma (NKTL), nasal-type is one of the most aggressive lymphoid malignancies and is characterized by an extremely poor survival outcome. The present study reports the case of a 39‑year‑old Chinese male with history of extranodal NKTL who presented with a painless indurated mass in the glans penis. The results of an incisional biopsy revealed atypical cells that were positive for CD3, CD56, T‑cell‑restricted intracellular antigen‑1, granzyme B and Epstein‑Barr virus‑encoded RNA, and negative for CD20. A diagnosis of metastatic NKTL was determined. The patient was treated with systemic chemotherapy consisting of cisplatin, dexamethasone, gemcitabine and pegaspargase, which resulted in remission and regression of the mass. In addition, a review of the literature was performed, and the data for 13 cases of non‑B‑cell penile lymphoma, including the present case, are presented. To the best of our knowledge, this is first review of this entity.

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