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Article Open Access

Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma

  • Authors:
    • Qiaoqi Wang
    • Xiangkun Wang
    • Qian Liang
    • Shijun Wang
    • Liao Xiwen
    • Fuqiang Pan
    • Hongyang Chen
    • Dong Li
  • View Affiliations / Copyright

    Affiliations: Cosmetic and Plastic Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7914-7922
    |
    Published online on: March 20, 2018
       https://doi.org/10.3892/ol.2018.8306
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Abstract

The purpose of the present study was to assess if guanylate-binding protein (GBP) mRNAs could be prognostic biomarkers for patients with skin cutaneous melanoma (SKCM). The prognostic value of GBP mRNA expression in patients with SKCM was investigated by analyzing gene expression data in 459 SKCM patients. The data were extracted from the OncoLnc database of The Cancer Genome Atlas. A high expression of GBP1, GBP2, GBP3, GBP4 and GBP5 were correlated with favorable overall survival (OS) in the SKCM patients followed for over 30 years. In addition, a high expression of GBP6 mRNA was not correlated with OS in the SKCM patients. A joint effects analysis showed that the co‑incidence of the high expression of GBP1-5 was correlated with favorable overall survival in SKCM patients. Our findings suggest that GBP1-5 mRNAs in SKCM are associated with favorable prognosis and may be potential prognostic biomarkers. The combination of GBP1-5 could improve the sensitivity for predicting OS in SKCM patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Wang X, Liang Q, Wang S, Xiwen L, Pan F, Chen H and Li D: Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma. Oncol Lett 15: 7914-7922, 2018.
APA
Wang, Q., Wang, X., Liang, Q., Wang, S., Xiwen, L., Pan, F. ... Li, D. (2018). Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma. Oncology Letters, 15, 7914-7922. https://doi.org/10.3892/ol.2018.8306
MLA
Wang, Q., Wang, X., Liang, Q., Wang, S., Xiwen, L., Pan, F., Chen, H., Li, D."Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma". Oncology Letters 15.5 (2018): 7914-7922.
Chicago
Wang, Q., Wang, X., Liang, Q., Wang, S., Xiwen, L., Pan, F., Chen, H., Li, D."Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma". Oncology Letters 15, no. 5 (2018): 7914-7922. https://doi.org/10.3892/ol.2018.8306
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Wang X, Liang Q, Wang S, Xiwen L, Pan F, Chen H and Li D: Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma. Oncol Lett 15: 7914-7922, 2018.
APA
Wang, Q., Wang, X., Liang, Q., Wang, S., Xiwen, L., Pan, F. ... Li, D. (2018). Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma. Oncology Letters, 15, 7914-7922. https://doi.org/10.3892/ol.2018.8306
MLA
Wang, Q., Wang, X., Liang, Q., Wang, S., Xiwen, L., Pan, F., Chen, H., Li, D."Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma". Oncology Letters 15.5 (2018): 7914-7922.
Chicago
Wang, Q., Wang, X., Liang, Q., Wang, S., Xiwen, L., Pan, F., Chen, H., Li, D."Distinct prognostic value of mRNA expression of guanylate-binding protein genes in skin cutaneous melanoma". Oncology Letters 15, no. 5 (2018): 7914-7922. https://doi.org/10.3892/ol.2018.8306
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