Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China

  • Authors:
    • Liang Xie
    • Wei Chen
    • Ran Dong
    • Bin He
    • Kaishun Zhao
    • Li Zhang
    • Min Zhou
    • Ping He
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Respiratory Disease, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Department of Respiration, Jiading Central Hospital, Shanghai 201800, P.R. China, Department of Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 8046-8052
    |
    Published online on: March 21, 2018
       https://doi.org/10.3892/ol.2018.8311
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study assessed the association between the variants of macrophage scavenger receptor (MSR)1 and chronic obstructive pulmonary disease (COPD), with or without lung cancer in China. COPD and lung cancer were previously regarded as two separate diseases. However, it has since been reported that there are close associations between COPD and lung cancer. Lung cancer may be an outcome of COPD. COPD may also coexist with lung cancer, and patients with COPD with lung cancer tend to have increased mortality. It is important to have a better understanding of the pathogenesis of COPD and the reason why it develops into lung cancer. MSR1 serves a crucial function in phagocytosis, which may be associated with the pathogenesis of COPD and lung cancer in patients with COPD. From 1 July 2015 to 20 February 2016, 100 patients with COPD and lung cancer, 100 patients with COPD without lung cancer and 100 healthy smokers were enrolled at the Shanghai Ruijin Hospital (Shanghai, China) for the genotyping of eight single‑nucleotide polymorphisms (SNPs; ex3P36A_C>G, ex3S41Y_C>A, ex4V113A_T>C, ex4P174Y_G>T, ex6P275A_C>G, ex6R293x_C>T, ex10G369S_G>A and ex11H441R_A>G) via gene sequencing. The genotype frequencies of these SNPs did not significantly differ between patients with COPD with and without lung cancer, and the healthy controls. However, during DNA sequencing, the SNP rs13306550 (IVS4+3A>G) was identified in the splice donor site and was significantly associated with an increased risk of COPD compared with the healthy smokers (P=0.0053). The present study demonstrated that the variant rs13306550 was a risk factor for COPD susceptibility, but that did not influence lung cancer pathogenesis in patients with COPD. However, the mechanisms underlying the influence of rs13306550 on COPD development and progression remain to be elucidated and require further study.
View Figures

Figure 1

View References

1 

Ko FW, Chan KP, Hui DS, Goddard JR, Shaw JG, Reid DW and Yang IA: Acute exacerbation of COPD. Respirology. 21:1152–1165. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Gridelli C, Rossi A, Carbone DP, Guarize J, Karachaliou N, Mok T, Petrella F, Spaggiari L and Rosell R: Non-small-cell lung cancer. Nat Rev Dis Primers. 1:150092015. View Article : Google Scholar : PubMed/NCBI

3 

Houghton AM: Mechanistic links between COPD and lung cancer. Nat Rev Cancer. 13:233–245. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Putcha N, Barr RG, Han MK, Woodruff PG, Bleecker ER, Kanner RE, Martinez FJ, Smith BM, Tashkin DP, Bowler RP, et al: Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort. Thorax: thoraxjnl-2015-207487. 2016. View Article : Google Scholar

5 

Dong R, Xie L, Zhao K, Zhang Q, Zhou M and He P: Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway. Int J Chron Obstruct Pulmon Dis. 11:31–41. 2015.PubMed/NCBI

6 

Cheng L, Liu J, Li B, Liu S, Li X and Tu H: Cigarette smoke-induced hypermethylation of the GCLC gene is associated with COPD. Chest. 149:474–482. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Kim CH, Lee YC, Hung RJ, McNallan SR, Cote ML, Lim WY, Chang SC, Kim JH, Ugolini D, Chen Y, et al: Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the international lung cancer consortium (ILCCO). Int J Cancer. 135:1918–1930. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Bossé Y: Updates on the COPD gene list. Int J Chron Obstruct Pulmon Dis. 7:607–631. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Hersh CP, DeMeo DL, Raby BA, Litonjua AA, Sylvia JS, Sparrow D, Reilly JJ and Silverman EK: Genetic linkage and association analysis of copd-related traits on chromosome 8p. COPD. 3:189–194. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ohar JA, Hamilton RF Jr, Zheng S, Sadeghnejad A, Sterling DA, Xu J, Meyers DA, Bleecker ER and Holian A: COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. Chest. 137:1098–1107. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Canton J, Neculai D and Grinstein S: Scavenger receptors in homeostasis and immunity. Nat Rev Immunol. 13:621–634. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Peiser L, Mukhopadhyay S and Gordon S: Scavenger receptors in innate immunity. Curr Opin Immunol. 14:123–128. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Taylor AE, Finney-Hayward TK, Quint JK, Thomas CM, Tudhope SJ, Wedzicha JA, Barnes PJ and Donnelly LE: Defective macrophage phagocytosis of bacteria in COPD. Eur Respir J. 35:1039–1047. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Hirayama S, Ishii G, Nagai K, Ono S, Kojima M, Yamauchi C, Aokage K, Hishida T, Yoshida J, Suzuki K and Ochiai A: Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: Possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment. J Thorac Oncol. 7:1790–1797. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Emi M, Asaoka H, Matsumoto A, Itakura H, Kurihara Y, Wada Y, Kanamori H, Yazaki Y, Takahashi E, Lepert M, et al: Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene. J Biol Chem. 268:2120–2125. 1993.PubMed/NCBI

16 

Walsh PC: Germline mutations and sequence variants of macrophage scavenger receptor 1 gene are associated with prostate cancer risk. J Urol. 169:1589–1590. 2003.PubMed/NCBI

17 

Pauwels RA, Buist AS, Calverley PM, Jenkins CR and Hurd SS: GOLD Scientific Committee: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med. 163:1256–1276. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, et al: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 176:532–555. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Grenier PA, Beigelman-Aubry C, Fetita CI and Brillet PY: CT imaging of chronic obstructive pulmonary disease: Role in phenotyping and interventions. Expert Opin Med Diagn. 3:689–703. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ben J, Jin G, Zhang Y, Ma B, Bai H, Chen J, Zhang H, Gong Q, Zhou X, Zhang H, et al: Class A scavenger receptor deficiency exacerbates lung tumorigenesis by cultivating a procarcinogenic microenvironment in humans and mice. Am J Respir Crit Care Med. 186:763–772. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Palecanda A and Kobzik L: Receptors for unopsonized particles: The role of alveolar macrophage scavenger receptors. Curr Mol Med. 1:589–595. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Barnes PJ: Alveolar macrophages as orchestrators of COPD. COPD. 1:59–70. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Valacchi G, Maioli E, Sticozzi C, Cervellati F, Pecorelli A, Cervellati C and Hayek J: Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis. Ann N Y Acad Sci. 1340:47–54. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Barnes PJ: Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 138:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Nurwidya F, Damayanti T and Yunus F: The role of innate and adaptive immune cells in the immunopathogenesis of chronic obstructive pulmonary disease. Tuberc Respir Dis (Seoul). 79:5–13. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Liu G and Yang H: Modulation of macrophage activation and programming in immunity. J Cell Physiol. 228:502–512. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Cheng C, Huang C, Ma TT, Bian EB, He Y, Zhang L and Li J: SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages. Toxicol Lett. 225:488–497. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Cosio MG, Saetta M and Agusti A: Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med. 360:2445–2454. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M and Hoshino T: Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease. PLoS One. 9:e874002014. View Article : Google Scholar : PubMed/NCBI

30 

Lindmark F, Jonsson BA, Bergh A, Stattin P, Zheng SL, Meyers DA, Xu J and Gronberg H: Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer. Prostate. 59:132–140. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Zeng L, Liu W, Feng W, Wang X, Dang H, Gao L, Yao J and Zhang X: A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family. Mol Vis. 19:2244–2249. 2013.PubMed/NCBI

32 

Krawczak M, Reiss J and Cooper DN: The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences. Hum Genet. 90:41–54. 1992. View Article : Google Scholar : PubMed/NCBI

33 

Kuronuma K, Sano H, Kato K, Kudo K, Hyakushima N, Yokota S, Takahashi H, Fujii N, Suzuki H, Kodama T, et al: Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. J Biol Chem. 279:21421–21430. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD and Gordon S: Macrophage receptors and immune recognition. Annu Rev Immunol. 23:901–944. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie L, Chen W, Dong R, He B, Zhao K, Zhang L, Zhou M and He P: Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China. Oncol Lett 15: 8046-8052, 2018.
APA
Xie, L., Chen, W., Dong, R., He, B., Zhao, K., Zhang, L. ... He, P. (2018). Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China. Oncology Letters, 15, 8046-8052. https://doi.org/10.3892/ol.2018.8311
MLA
Xie, L., Chen, W., Dong, R., He, B., Zhao, K., Zhang, L., Zhou, M., He, P."Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China". Oncology Letters 15.5 (2018): 8046-8052.
Chicago
Xie, L., Chen, W., Dong, R., He, B., Zhao, K., Zhang, L., Zhou, M., He, P."Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China". Oncology Letters 15, no. 5 (2018): 8046-8052. https://doi.org/10.3892/ol.2018.8311
Copy and paste a formatted citation
x
Spandidos Publications style
Xie L, Chen W, Dong R, He B, Zhao K, Zhang L, Zhou M and He P: Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China. Oncol Lett 15: 8046-8052, 2018.
APA
Xie, L., Chen, W., Dong, R., He, B., Zhao, K., Zhang, L. ... He, P. (2018). Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China. Oncology Letters, 15, 8046-8052. https://doi.org/10.3892/ol.2018.8311
MLA
Xie, L., Chen, W., Dong, R., He, B., Zhao, K., Zhang, L., Zhou, M., He, P."Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China". Oncology Letters 15.5 (2018): 8046-8052.
Chicago
Xie, L., Chen, W., Dong, R., He, B., Zhao, K., Zhang, L., Zhou, M., He, P."Function of macrophage scavenger receptor 1 gene polymorphisms in chronic obstructive pulmonary disease with and without lung cancer in China". Oncology Letters 15, no. 5 (2018): 8046-8052. https://doi.org/10.3892/ol.2018.8311
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team