Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas

  • Authors:
    • Koji Takano
    • Manabu Kinoshita
    • Hideyuki Arita
    • Yoshiko Okita
    • Yasuyoshi Chiba
    • Naoki Kagawa
    • Yoshiyuki Watanabe
    • Eku Shimosegawa
    • Jun Hatazawa
    • Naoya Hashimoto
    • Yasunori Fujimoto
    • Haruhiko Kishima
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Osaka International Cancer Institute, Osaka 541‑8567, Japan, Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540‑0006, Japan, Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Neurosurgery, Kyoto Prefectural University Graduate School of Medical Science, Kyoto 602‑8566, Japan
    Copyright: © Takano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7934-7940
    |
    Published online on: March 22, 2018
       https://doi.org/10.3892/ol.2018.8319
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A number of studies have revealed the usefulness of multimodal imaging in gliomas. Although the results have been heavily affected by the method used for region of interest (ROI) design, the most discriminatory method for setting the ROI remains unclear. The aim of the present study was to determine the most suitable ROI design for 18F‑fluorodeoxyglucose (FDG) and 11C‑methionine (MET) positron emission tomography (PET), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) obtained by diffusion tensor imaging (DTI) from the viewpoint of grades of non‑enhancing gliomas. A total of 31 consecutive patients with newly diagnosed, histologically confirmed magnetic resonance (MR) non‑enhancing gliomas who underwent FDG‑PET, MET‑PET and DTI were retrospectively investigated. Quantitative measurements were performed using four different ROIs; hotspot/tumor center and whole tumor, constructed in either two‑dimensional (2D) or three‑dimensional (3D). Histopathological grading of the tumor was considered as empirical truth and the quantitative measurements obtained from each ROI was correlated with the grade of the tumor. The most discriminating ROI for non‑enhancing glioma grading was different according to the different imaging modalities. 2D‑hotspot/center ROI was most discriminating for FDG‑PET (P=0.087), ADC map (P=0.0083), and FA map (P=0.25), whereas 3D‑whole tumor ROI was best for MET‑PET (P=0.0050). In the majority of scenarios, 2D‑ROIs performed better than 3D‑ROIs. Results from the image analysis using FDG‑PET, MET‑PET, ADC and FA may be affected by ROI design and the most discriminating ROI for non‑enhancing glioma grading was different according to the imaging modality.
View Figures

Figure 1

Figure 2

View References

1 

Goebell E, Paustenbach S, Vaeterlein O, Ding XQ, Heese O, Fiehler J, Kucinski T, Hagel C, Westphal M and Zeumer H: Low-grade and anaplastic gliomas: Differences in architecture evaluated with diffusion-tensor MR imaging. Radiology. 239:217–222. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Lee EJ, Lee SK, Agid R, Bae JM, Keller A and Terbrugge K: Preoperative grading of presumptive low-grade astrocytomas on MR imaging: Diagnostic value of minimum apparent diffusion coefficient. AJNR Am J Neuroradiol. 29:1872–1877. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Lee HY, Na DG, Song IC, Lee DH, Seo HS, Kim JH and Chang KH: Diffusion-tensor imaging for glioma grading at 3-T magnetic resonance imaging: Analysis of fractional anisotropy and mean diffusivity. J Comput Assist Tomogr. 32:298–303. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Higano S, Yun X, Kumabe T, Watanabe M, Mugikura S, Umetsu A, Sato A, Yamada T and Takahashi S: Malignant astrocytic tumors: Clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology. 241:839–846. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Van Laere K, Ceyssens S, Van Calenbergh F, de Groot T, Menten J, Flamen P, Bormans G and Mortelmans L: Direct comparison of 18F-FDG and 11C-methionine PET in suspected recurrence of glioma: Sensitivity, inter-observer variability and prognostic value. Eur J Nucl Med Mol Imaging. 32:39–51. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Stadlbauer A, Ganslandt O, Buslei R, Hammen T, Gruber S, Moser E, Buchfelder M, Salomonowitz E and Nimsky C: Gliomas: Histopathologic evaluation of changes in directionality and magnitude of water diffusion at diffusion-tensor MR imaging. Radiology. 240:803–810. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Kinoshita M, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N and Yoshimine T: Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors. Neuro Image. 43:29–35. 2008.PubMed/NCBI

8 

Liu X, Tian W, Kolar B, Yeaney GA, Qiu X, Johnson MD and Ekholm S: MR diffusion tensor and perfusion-weighted imaging in preoperative grading of supratentorial nonenhancing gliomas. Neuro Oncol. 13:447–455. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Singhal T, Narayanan TK, Jacobs MP, Bal C and Mantil JC: 11C-methionine PET for grading and prognostication in gliomas: A comparison study with 18F-FDG PET and contrast enhancement on MRI. J Nucl Med. 53:1709–1715. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Okita Y, Nonaka M, Shofuda T, Kanematsu D, Yoshioka E, Kodama Y, Mano M, Nakajima S and Kanemura Y: (11)C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas. Clin Neurol Neurosurg. 125:212–216. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Berger G, Maziere M, Knipper R, Prenant C and Comar D: Automated synthesis of 11C-labelled radiopharmaceuticals: Imipramine, chlorpromazine, nicotine and methionine. Int J Appl Radiat Isot. 30:393–399. 1979. View Article : Google Scholar : PubMed/NCBI

12 

Yoshiura T, Mihara F, Tanaka A, Ogomori K, Ohyagi Y, Taniwaki T, Yamada T, Yamasaki T, Ichimiya A, Kinukawa N, et al: High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease. NeuroImage. 20:413–419. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Di Chiro G, DeLaPaz RL, Brooks RA, Sokoloff L, Kornblith PL, Smith BH, Patronas NJ, Kufta CV, Kessler RM, Johnston GS, et al: Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography. Neurology. 32:1323–1329. 1982. View Article : Google Scholar : PubMed/NCBI

14 

Murakami R, Hirai T, Sugahara T, Fukuoka H, Toya R, Nishimura S, Kitajima M, Okuda T, Nakamura H, Oya N, et al: Grading astrocytic tumors by using apparent diffusion coefficient parameters: Superiority of a one- vs. two-parameter pilot method. Radiology. 251:838–845. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Fan GG, Deng QL, Wu ZH and Guo QY: Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: A valuable tool to predict tumour grading? Br J Radiol. 79:652–658. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, et al: Comparison of diffusion tensor imaging and (11)C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas. J Neurosurg. 125:1136–1142. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Beppu T, Inoue T, Shibata Y, Yamada N, Kurose A, Ogasawara K, Ogawa A and Kabasawa H: Fractional anisotropy value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas. Surg Neurol. 63:D56–D61. 2005. View Article : Google Scholar

18 

Ishiwata K, Kubota K, Murakami M, Kubota R and Senda M: A comparative study on protein incorporation of L-[methyl-3H]methionine, L-[1-14C]leucine and L-2-[18F]fluorotyrosine in tumor bearing mice. Nucl Med Biol. 20:895–899. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ and Piers DA: Radiolabeled amino acids: Basic aspects and clinical applications in oncology. J Nucl Med. 42:432–445. 2001.PubMed/NCBI

20 

Stern PH, Wallace CD and Hoffman RM: Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines. J Cell Physiol. 119:29–34. 1984. View Article : Google Scholar : PubMed/NCBI

21 

Herholz K, Hölzer T, Bauer B, Schröder R, Voges J, Ernestus RI, Mendoza G, Weber-Luxenburger G, Löttgen J, Thiel A, et al: 11C-methionine PET for differential diagnosis of low-grade gliomas. Neurology. 50:1316–1322. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Pirotte B, Goldman S, Dewitte O, Massager N, Wikler D, Lefranc F, Ben Taib NO, Rorive S, David P, Brotchi J and Levivier M: Integrated positron emission tomography and magnetic resonance imaging-guided resection of brain tumors: A report of 103 consecutive procedures. J Neurosurg. 104:238–253. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Galanis E, Buckner JC, Maurer MJ, Sykora R, Castillo R, Ballman KV and Erickson BJ: Validation of neuroradiologic response assessment in gliomas: Measurement by RECIST, two-dimensional, computer-assisted tumor area and computer-assisted tumor volume methods. Neuro Oncol. 8:156–165. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Gállego Pérez-Larraya J, Lahutte M, Petrirena G, Reyes-Botero G, González-Aguilar A, Houillier C, Guillevin R, Sanson M, Hoang-Xuan K and Delattre JY: Response assessment in recurrent glioblastoma treated with irinotecan-bevacizumab: Comparative analysis of the Macdonald, RECIST, RANO and RECIST + F criteria. Neuro Oncol. 14:667–673. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Shah GD, Kesari S, Xu R, Batchelor TT, O'Neill AM, Hochberg FH, Levy B, Bradshaw J and Wen PY: Comparison of linear and volumetric criteria in assessing tumor response in adult high-grade gliomas. Neuro Oncol. 8:38–46. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Watanabe Y, Shimosegawa E, Hatazawa J, Hashimoto N, Hashimoto N, et al: Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas. Oncol Lett 15: 7934-7940, 2018.
APA
Takano, K., Kinoshita, M., Arita, H., Okita, Y., Chiba, Y., Kagawa, N. ... Kishima, H. (2018). Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas. Oncology Letters, 15, 7934-7940. https://doi.org/10.3892/ol.2018.8319
MLA
Takano, K., Kinoshita, M., Arita, H., Okita, Y., Chiba, Y., Kagawa, N., Watanabe, Y., Shimosegawa, E., Hatazawa, J., Hashimoto, N., Fujimoto, Y., Kishima, H."Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas". Oncology Letters 15.5 (2018): 7934-7940.
Chicago
Takano, K., Kinoshita, M., Arita, H., Okita, Y., Chiba, Y., Kagawa, N., Watanabe, Y., Shimosegawa, E., Hatazawa, J., Hashimoto, N., Fujimoto, Y., Kishima, H."Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas". Oncology Letters 15, no. 5 (2018): 7934-7940. https://doi.org/10.3892/ol.2018.8319
Copy and paste a formatted citation
x
Spandidos Publications style
Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Watanabe Y, Shimosegawa E, Hatazawa J, Hashimoto N, Hashimoto N, et al: Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas. Oncol Lett 15: 7934-7940, 2018.
APA
Takano, K., Kinoshita, M., Arita, H., Okita, Y., Chiba, Y., Kagawa, N. ... Kishima, H. (2018). Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas. Oncology Letters, 15, 7934-7940. https://doi.org/10.3892/ol.2018.8319
MLA
Takano, K., Kinoshita, M., Arita, H., Okita, Y., Chiba, Y., Kagawa, N., Watanabe, Y., Shimosegawa, E., Hatazawa, J., Hashimoto, N., Fujimoto, Y., Kishima, H."Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas". Oncology Letters 15.5 (2018): 7934-7940.
Chicago
Takano, K., Kinoshita, M., Arita, H., Okita, Y., Chiba, Y., Kagawa, N., Watanabe, Y., Shimosegawa, E., Hatazawa, J., Hashimoto, N., Fujimoto, Y., Kishima, H."Influence of region‑of‑interest designs on quantitative measurement of multimodal imaging of MR non‑enhancing gliomas". Oncology Letters 15, no. 5 (2018): 7934-7940. https://doi.org/10.3892/ol.2018.8319
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team