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Article

Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer

  • Authors:
    • Wei‑Jun Yang
    • Ying‑Xue Hao
    • Xia Yang
    • Xiao‑Lan Fu
    • Yan Shi
    • Hai‑Ling Yue
    • Peng Yin
    • Hao‑Lin Dong
    • Pei‑Wu Yu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery and Center of Minimally Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China, Department of Immunology, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 8027-8033
    |
    Published online on: March 23, 2018
       https://doi.org/10.3892/ol.2018.8329
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Abstract

Tunica Interna endothelial cell kinase (Tie2)‑expressing macrophages (TEMs) are a subgroup of tumor‑associated macrophages that are associated with a poor prognosis in numerous types of cancer. The present study aimed to assess the prognostic impact of Tie2 expression in gastric cancer tissues. Between January 2009 and December 2009, 76 newly diagnosed patients with gastric cancer at the Southwest Hospital, Third Military Medical University (Chongqing, China) were enrolled. TEMs were detected using immunohistochemistry. Tie2, cluster of differentiation (CD)68 and carbonic anhydrase IX (CAIX) were analyzed using immunohistochemistry and immunofluorescent microscopy. Tie2 protein expression was analyzed using western blot analysis in hypoxic and normoxic gastric cancer tissues. The number of TEMs positively staining for Tie2 increased with the tumor‑node‑metastasis (TNM) stage: 0, 53.9, 75.6 and 100% in stages I, II, III and IV, respectively (P<0.001). Tumor size and lymph node involvement were significantly associated with the presence of Tie2 in the tumor stroma (P<0.001). There was no significant difference between Tie2 and CAIX, irrespective of how the patients were grouped (tumor size, lymph node involvement, TNM stage or histological grade). Tie2 protein expression was increased in the hypoxic regions of gastric tumors.Tie2 and CD68 expression colocalized in hypoxic and normoxic gastric cancer tissues. The 1‑, 2‑ and 3‑year recurrence rates of the TEM‑positive group were 31.4, 56.9 and 66.7%, respectively, as compared with 8, 28 and 48%, respectively, for the TEM‑negative group (P<0.05). In the TEM‑negative group, 2 patients succumbed to the disease, as compared with 21 patients in the TEM‑positive group (P<0.05). Therefore, high quantities of TEMs, represented by Tie2 expression, in gastric tumors may be associated with poor survival.
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1 

Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LA, Eheman C, Jemal A, Anderson RN, Ajani UA and Edwards BK: Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst. 103:714–736. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Bertuccio P, Chatenoud L, Levi F, Praud D, Ferlay J, Negri E, Malvezzi M and La Vecchia C: Recent patterns in gastric cancer: A global overview. Int J Cancer. 125:666–673. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Zhu H, Yang X, Zhang C, Zhu C, Tao G, Zhao L, Tang S, Shu Z, Cai J, Dai S, et al: Red and processed meat intake is associated with higher gastric cancer risk: A meta-analysis of epidemiological observational studies. PLoS One. 8:e709552013. View Article : Google Scholar : PubMed/NCBI

4 

Doll R, Peto R, Boreham J and Sutherland I: Mortality from cancer in relation to smoking: 50 years observations on British doctors. Br J Cancer. 92:426–429. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Marrelli D, Morgagni P, de Manzoni G, Coniglio A, Marchet A, Saragoni L, Tiberio G and Roviello F: Italian Research Group for Gastric C (IRGGC): Prognostic value of the 7th AJCC/UICC TNM classification of noncardia gastric cancer: Analysis of a large series from specialized Western centers. Ann Surg. 255:486–491. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wagner AD, Unverzagt S, Grothe W, Kleber G, Grothey A, Haerting J and Fleig WE: Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev: CD004064. 2010. View Article : Google Scholar

7 

Gertler R, Rosenberg R, Feith M, Schuster T and Friess H: Pouch vs. no pouch following total gastrectomy: Meta-analysis and systematic review. Am J Gastroenterol. 104:2838–2851. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Pollard JW: Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 4:71–78. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Balkwill F, Charles KA and Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell. 7:211–217. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Lewis CE and Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66:605–612. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Noy R and Pollard JW: Tumor-associated macrophages: From mechanisms to therapy. Immunity. 41:49–61. 2014. View Article : Google Scholar : PubMed/NCBI

12 

van Netten JP, George EJ, Ashmead BJ, Fletcher C, Thornton IG and Coy P: Macrophage-tumour cell associations in breast cancer. Lancet. 342:872–873. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Takanami I, Takeuchi K and Kodaira S: Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: Association with angiogenesis and poor prognosis. Oncology. 57:138–142. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Tsutsui S, Yasuda K, Suzuki K, Tahara K, Higashi H and Era S: Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density. Oncol Rep. 14:425–431. 2005.PubMed/NCBI

15 

Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY and Suda T: Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 118:149–161. 2004. View Article : Google Scholar : PubMed/NCBI

16 

De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M and Naldini L: Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell. 8:211–226. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Venneri MA, De Palma M, Ponzoni M, Pucci F, Scielzo C, Zonari E, Mazzieri R, Doglioni C and Naldini L: Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood. 109:5276–5285. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Bingle L, Brown NJ and Lewis CE: The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies. J Pathol. 196:254–265. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Medrek C, Ponten F, Jirstrom K and Leandersson K: The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer. 12:3062012. View Article : Google Scholar : PubMed/NCBI

20 

Kübler K, Ayub TH, Weber SK, Zivanovic O, Abramian A, Keyver-Paik MD, Mallmann MR, Kaiser C, Serçe NB, Kuhn W and Rudlowski C: Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma. Gynecol Oncol. 135:176–183. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Greene FL, Page DL, Fleming ID, et al: AJCC cancer staging handbook. New York: Springer; 2001

22 

Ajani JA, Beaii-saab T, Yang G, et al: NCCN clinical practice guidelines in oncology[M]: gastric cancer. 2009.

23 

Kaluz S, Kaluzova M and Stanbridge EJ: The role of extracellular signal-regulated protein kinase in transcriptional regulation of the hypoxia marker carbonic anhydrase IX. J Cell Biochem. 97:207–216. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouysségur J and Berra E: HIF-1alpha and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome. Int J Cancer. 120:1451–1458. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Hussain SA, Ganesan R, Reynolds G, Gross L, Stevens A, Pastorek J, Murray PG, Perunovic B, Anwar MS, Billingham L, et al: Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer. Br J Cancer. 96:104–109. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Brahimi-Horn MC and Pouyssegur J: The hypoxia-inducible factor and tumor progression along the angiogenic pathway. Int Rev Cytol. 242:157–213. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, et al: Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 71:741–747. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Hu B and Cheng SY: Angiopoietin-2: Development of inhibitors for cancer therapy. Curr Oncol Rep. 11:111–116. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Etoh T, Inoue H, Tanaka S, Barnard GF, Kitano S and Mori M: Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: Possible in vivo regulation via induction of proteases. Cancer Res. 61:2145–2153. 2001.PubMed/NCBI

30 

Murdoch C, Giannoudis A and Lewis CE: Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 104:2224–2234. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L and Lewis CE: Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol. 163:1233–1243. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Bingle L, Lewis CE, Corke KP, Reed MW and Brown NJ: Macrophages promote angiogenesis in human breast tumour spheroids in vivo. Br J Cancer. 94:101–107. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Murdoch C, Tazzyman S, Webster S and Lewis CE: Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol. 178:7405–7411. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Lewis CE, De Palma M and Naldini L: Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoietin-2. Cancer Res. 67:8429–8432. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Manzur M, Hamzah J and Ganss R: Modulation of the ‘blood-tumor’ barrier improves immunotherapy. Cell Cycle. 7:2452–2455. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang WJ, Hao YX, Yang X, Fu XL, Shi Y, Yue HL, Yin P, Dong HL and Yu PW: Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer. Oncol Lett 15: 8027-8033, 2018.
APA
Yang, W., Hao, Y., Yang, X., Fu, X., Shi, Y., Yue, H. ... Yu, P. (2018). Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer. Oncology Letters, 15, 8027-8033. https://doi.org/10.3892/ol.2018.8329
MLA
Yang, W., Hao, Y., Yang, X., Fu, X., Shi, Y., Yue, H., Yin, P., Dong, H., Yu, P."Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer". Oncology Letters 15.5 (2018): 8027-8033.
Chicago
Yang, W., Hao, Y., Yang, X., Fu, X., Shi, Y., Yue, H., Yin, P., Dong, H., Yu, P."Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer". Oncology Letters 15, no. 5 (2018): 8027-8033. https://doi.org/10.3892/ol.2018.8329
Copy and paste a formatted citation
x
Spandidos Publications style
Yang WJ, Hao YX, Yang X, Fu XL, Shi Y, Yue HL, Yin P, Dong HL and Yu PW: Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer. Oncol Lett 15: 8027-8033, 2018.
APA
Yang, W., Hao, Y., Yang, X., Fu, X., Shi, Y., Yue, H. ... Yu, P. (2018). Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer. Oncology Letters, 15, 8027-8033. https://doi.org/10.3892/ol.2018.8329
MLA
Yang, W., Hao, Y., Yang, X., Fu, X., Shi, Y., Yue, H., Yin, P., Dong, H., Yu, P."Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer". Oncology Letters 15.5 (2018): 8027-8033.
Chicago
Yang, W., Hao, Y., Yang, X., Fu, X., Shi, Y., Yue, H., Yin, P., Dong, H., Yu, P."Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer". Oncology Letters 15, no. 5 (2018): 8027-8033. https://doi.org/10.3892/ol.2018.8329
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