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Article Open Access

Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway

Corrigendum in: /10.3892/ol.2021.12503
  • Authors:
    • Yuxue Gao
    • Lihong Shi
    • Zhen Cao
    • Xuetao Zhu
    • Feng Li
    • Ruyan Wang
    • Jinyuan Xu
    • Jinyi Zhong
    • Baogang Zhang
    • Shijun Lu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, School of Clinical Medicine, Weifang, Shandong 261053, P.R. China, Department of Pharmacology, Weifang Medical University, Weifang, Shandong 261053, P.R. China, Department of Pathology, Key Clinical Specialty for Pathology of Shandong Province, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261053, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7837-7845
    |
    Published online on: March 26, 2018
       https://doi.org/10.3892/ol.2018.8349
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Abstract

Telocinobufagin (TBG), an active ingredient of Venenumbufonis, exhibits an immunomodulatory activity. However, its antimetastatic activity in breast cancer remains unknown. The present study investigated whether TBG prevents breast cancer metastasis and evaluated its regulatory mechanism. TBG inhibited the migration and invasion of 4T1 breast cancer cells. Furthermore, TBG triggered the collapse of F‑actin filaments in breast cancer. The epithelial‑mesenchymal transition (EMT) markers, vimentin and fibronectin, were downregulated following TBG treatment. However, E‑cadherin was upregulated following TBG treatment. Snail, a crucial transcriptional factor of EMT, was downregulated following TBG treatment. Signaling pathway markers, including phosphorylated protein kinase B (P‑Akt), p‑mechanistic target of rapamycin (mTOR) and p‑extracellular signal‑regulated kinase (ERK), were decreased following TBG treatment. The same results were obtained from in vivo experiments. In conclusion, in vitro and in vivo experiments reveal that TBG inhibited migration, invasion and EMT via the phosphoinositide 3‑kinase (PI3K)/Akt/ERK/Snail signaling pathway in breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Shi L, Cao Z, Zhu X, Li F, Wang R, Xu J, Zhong J, Zhang B, Lu S, Lu S, et al: Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503. Oncol Lett 15: 7837-7845, 2018.
APA
Gao, Y., Shi, L., Cao, Z., Zhu, X., Li, F., Wang, R. ... Lu, S. (2018). Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503. Oncology Letters, 15, 7837-7845. https://doi.org/10.3892/ol.2018.8349
MLA
Gao, Y., Shi, L., Cao, Z., Zhu, X., Li, F., Wang, R., Xu, J., Zhong, J., Zhang, B., Lu, S."Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503". Oncology Letters 15.5 (2018): 7837-7845.
Chicago
Gao, Y., Shi, L., Cao, Z., Zhu, X., Li, F., Wang, R., Xu, J., Zhong, J., Zhang, B., Lu, S."Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503". Oncology Letters 15, no. 5 (2018): 7837-7845. https://doi.org/10.3892/ol.2018.8349
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Shi L, Cao Z, Zhu X, Li F, Wang R, Xu J, Zhong J, Zhang B, Lu S, Lu S, et al: Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503. Oncol Lett 15: 7837-7845, 2018.
APA
Gao, Y., Shi, L., Cao, Z., Zhu, X., Li, F., Wang, R. ... Lu, S. (2018). Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503. Oncology Letters, 15, 7837-7845. https://doi.org/10.3892/ol.2018.8349
MLA
Gao, Y., Shi, L., Cao, Z., Zhu, X., Li, F., Wang, R., Xu, J., Zhong, J., Zhang, B., Lu, S."Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503". Oncology Letters 15.5 (2018): 7837-7845.
Chicago
Gao, Y., Shi, L., Cao, Z., Zhu, X., Li, F., Wang, R., Xu, J., Zhong, J., Zhang, B., Lu, S."Telocinobufagin inhibits the epithelial‑mesenchymal transition of breast cancer cells through the phosphoinositide 3‑kinase/protein kinase B/extracellular signal‑regulated kinase/Snail signaling pathway Corrigendum in /10.3892/ol.2021.12503". Oncology Letters 15, no. 5 (2018): 7837-7845. https://doi.org/10.3892/ol.2018.8349
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