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Article Open Access

Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO

  • Authors:
    • Shasha Hou
    • Jian Tan
    • Bing Yang
    • Lu He
    • Yu Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P.R. China, Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P.R. China, Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vessels and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7889-7899
    |
    Published online on: March 26, 2018
       https://doi.org/10.3892/ol.2018.8356
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Abstract

Thyroid cancer is a common primary tumor in China. Therefore, it is important to investigate the underlying molecular mechanism of thyroid cancer in order to achieve effective individualized treatments. In our previous study, a positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines was identified. The inactivation of AGPS was able to decrease the malignancy of cancer, and inhibit tumor growth and invasion. However, the function of AGPS on thyroid cancer was unclear. In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed in order to investigate the underlying molecular mechanism of AGPS for the regulation of thyroid cancer through circRNAs.
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Copy and paste a formatted citation
Spandidos Publications style
Hou S, Tan J, Yang B, He L and Zhu Y: Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. Oncol Lett 15: 7889-7899, 2018.
APA
Hou, S., Tan, J., Yang, B., He, L., & Zhu, Y. (2018). Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. Oncology Letters, 15, 7889-7899. https://doi.org/10.3892/ol.2018.8356
MLA
Hou, S., Tan, J., Yang, B., He, L., Zhu, Y."Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO". Oncology Letters 15.5 (2018): 7889-7899.
Chicago
Hou, S., Tan, J., Yang, B., He, L., Zhu, Y."Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO". Oncology Letters 15, no. 5 (2018): 7889-7899. https://doi.org/10.3892/ol.2018.8356
Copy and paste a formatted citation
x
Spandidos Publications style
Hou S, Tan J, Yang B, He L and Zhu Y: Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. Oncol Lett 15: 7889-7899, 2018.
APA
Hou, S., Tan, J., Yang, B., He, L., & Zhu, Y. (2018). Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. Oncology Letters, 15, 7889-7899. https://doi.org/10.3892/ol.2018.8356
MLA
Hou, S., Tan, J., Yang, B., He, L., Zhu, Y."Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO". Oncology Letters 15.5 (2018): 7889-7899.
Chicago
Hou, S., Tan, J., Yang, B., He, L., Zhu, Y."Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO". Oncology Letters 15, no. 5 (2018): 7889-7899. https://doi.org/10.3892/ol.2018.8356
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