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Article

Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells

  • Authors:
    • Xiaoguang Wang
    • Bin Wu
    • Zhengxiang Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Jiaxing Medical College, Jiaxing, Zhejiang 314000, P.R. China
  • Pages: 585-593
    |
    Published online on: May 4, 2018
       https://doi.org/10.3892/ol.2018.8633
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Abstract

Yes‑associated protein (YAP) serves an essential role in tumorigenesis. However, the potential role and the molecular mechanism underlying the effect of YAP on hepatocellular carcinoma (HCC) cells have not been elucidated. In the current study, it was revealed that YAP expression was increased significantly in HCC cancer tissues and its overexpression was associated with tumor differentiation. The silencing of YAP by small interferring RNA led to the inhibition of HCC cell growth, which was associated with the promotion of apoptosis. The silencing of YAP also decreased the invasive potential of HCC cells and the activity of the phosphoinositide 3‑kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling pathway. Furthermore, silencing of YAP increased the chemosensitivity of HCC cells to cisplatin (CDDP) through inactivation of the PI3K/AKT signaling pathway. In vivo studies using PDTX model suggested a promotive role for YAP in the growth of HCC and knockdown of YAP increased the anti‑tumor activity of CDDP. Taken together, these results revealed that YAP is overexpressed in HCC, and promotes proliferation, invasion and drug resistance of HCC cells. Inhibition of YAP, alone or in combination with traditional chemotherapy, may effectively combat HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wu B and Zhong Z: Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncol Lett 16: 585-593, 2018.
APA
Wang, X., Wu, B., & Zhong, Z. (2018). Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncology Letters, 16, 585-593. https://doi.org/10.3892/ol.2018.8633
MLA
Wang, X., Wu, B., Zhong, Z."Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells". Oncology Letters 16.1 (2018): 585-593.
Chicago
Wang, X., Wu, B., Zhong, Z."Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells". Oncology Letters 16, no. 1 (2018): 585-593. https://doi.org/10.3892/ol.2018.8633
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wu B and Zhong Z: Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncol Lett 16: 585-593, 2018.
APA
Wang, X., Wu, B., & Zhong, Z. (2018). Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncology Letters, 16, 585-593. https://doi.org/10.3892/ol.2018.8633
MLA
Wang, X., Wu, B., Zhong, Z."Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells". Oncology Letters 16.1 (2018): 585-593.
Chicago
Wang, X., Wu, B., Zhong, Z."Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells". Oncology Letters 16, no. 1 (2018): 585-593. https://doi.org/10.3892/ol.2018.8633
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