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Talin2 regulates breast cancer cell migration and invasion by apoptosis

  • Authors:
    • Yingfan Liang
    • Hongwei Chen
    • Ling Ji
    • Jinfu Du
    • Xiaofan Xie
    • Xiang Li
    • Yongliang Lou
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, P.R. China, Department of Colorectal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, Renji College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 285-293
    |
    Published online on: May 4, 2018
       https://doi.org/10.3892/ol.2018.8641
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Abstract

Talin is a key component molecule of the extracellular matrix‑integrin‑cytoskeleton. It serves an important role in the activation of integrin, which, in turn, is known to mediate physiological and pathological processes, including cell adhesion, growth, tumorigenesis, and metastasis. In vertebrates, there are two Talin genes, Talin1 and Talin2. Talin1 is known to regulate focal adhesion dynamics, cell migration and cell invasion; however, the precise role of Talin2 in cancer remains unclear. In the present study, the functional role of Talin2 was examined in the MDA‑MB‑231 breast cancer cell line. Talin2 knockdown significantly inhibited growth, migratory capacity and invasiveness of MDA‑MB‑231 cells, and promoted apoptosis. The expression levels of Talin2 in breast cancer cells and in the peritumoral normal breast tissues were also determined by immunohistochemistry. Talin2 was identified to be overexpressed in breast cancer tissues compared with that in the peritumoral breast tissues. In addition, the knockdown of Talin2 by specific RNA interference markedly inhibited cell growth, and caused the downregulation of the apoptotic markers, cleaved Caspase‑3 and phosphorylation of poly ADP‑ribose polymerase. These findings demonstrate that Talin2 expression is upregulated in human breast cancer and that downregulation of Talin2 may serve as a useful therapeutic target in patients with breast cancer.
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1 

Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3:524–548. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Christofori G: New signals from the invasive front. Nature. 441:444–450. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Burridge K and Connell L: A new protein of adhesion plaques and ruffling membranes. J Cell Biol. 97:359–367. 1983. View Article : Google Scholar : PubMed/NCBI

6 

Critchley DR: Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 38:235–254. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Moser M, Legate KR, Zent R and Fassler R: The tail of integrins, talin, and kindlins. Science. 324:895–899. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Wehrle-Haller B: Structure and function of focal adhesions. Curr Opin Cell Biol. 24:116–124. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Monkley SJ, Pritchard CA and Critchley DR: Analysis of the mammalian talin2 gene TLN2. Biochem Biophys Res Commun. 286:880–885. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Debrand E, El Jai Y, Spence L, Bate N, Praekelt U, Pritchard CA, Monkley SJ and Critchley DR: Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. FEBS J. 276:1610–1628. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Senetar MA, Moncman CL and McCann RO: Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle. Cell Motil Cytoskeleton. 64:157–173. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Tsujioka M, Yoshida K and Inouye K: Talin B is required for force transmission in morphogenesis of Dictyostelium. EMBO J. 23:2216–2225. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, et al: New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for Talin1 and Talin2. Eur J Cell Biol. 91:180–191. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Senetar MA and McCann RO: Gene duplication and functional divergence during evolution of the cytoskeletal linker protein Talin. Gene. 362:141–152. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K and Ginsberg MH: Talin phosphorylation by Cdk5 regulates Smurf1-mediated Talin head ubiquitylation and cell migration. Nat Cell Biol. 11:624–630. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Jin JK, Tien PC, Cheng CJ, Song JH, Huang C, Lin SH and Gallick GE: Talin1 phosphorylation activates β1 integrins: A novel mechanism to promote prostate cancer bone metastasis. Oncogene. 34:1811–1821. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Sakamoto S, McCann RO, Dhir R and Kyprianou N: Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance. Cancer Res. 70:1885–1895. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Fang KP, Dai W, Ren YH, Xu YC, Zhang SM and Qian YB: Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell. BMC Cancer. 16:452016. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Wu Z, Li X, Sunkara M, Spearman H, Morris AJ and Huang C: PIPKIgamma regulates focal adhesion dynamics and colon cancer cell invasion. PLoS One. 6:e247752011. View Article : Google Scholar : PubMed/NCBI

21 

Liu B, Pang B, Hou X, Fan H, Liang N, Zheng S, Feng B, Liu W, Guo H, Xu S and Pang Q: Expression of high-mobility group AT-hook protein 2 and its prognostic significance in malignant gliomas. Hum Pathol. 45:1752–1758. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Li Na, Gao Junyan and Liu Min: Research on the relationship between apoptosis and tumor. Contemporary Medicine. 15:13–14. 2009.

23 

Boggs AE, Vitolo MI, Whipple RA, Charpentier MS, Goloubeva OG, Ioffe OB, Tuttle KC, Slovic J, Lu Y, Mills GB and Martin SS: α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration. Cancer Res. 75:203–215. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Haining AW, Lieberthal TJ and Del Rio Hernandez A: Talin: A mechanosensitive molecule in health and disease. FASEB J. 30:2073–2085. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Li L, Li X, Qi L, Rychahou P, Jafari N and Huang C: The role of talin2 in breast cancer tumorigenesis and metastasis. Oncotarget. 8:106876–106887. 2017.PubMed/NCBI

26 

Le XF, Almeida MI, Mao W, Spizzo R, Rossi S, Nicoloso MS, Zhang S, Wu Y, Calin GA and Bast RC Jr: Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer. PLoS One. 7:e411702012. View Article : Google Scholar : PubMed/NCBI

27 

Krysko DV, Vanden Berghe T, D'Herde K and Vandenabeele P: Apoptosis and necrosis: Detection, discrimination and phagocytosis. Methods. 44:205–221. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Li JY, Luo H and Yu L: FMNL2 regulates cell migration and Src and Talin expressionin colorectaI cancer cell. Shijie Huaren Xiao Hua Za Zhi. 20:289–295. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Chen H, Ji L, Du J, Xie X, Li X and Lou Y: Talin2 regulates breast cancer cell migration and invasion by apoptosis. Oncol Lett 16: 285-293, 2018.
APA
Liang, Y., Chen, H., Ji, L., Du, J., Xie, X., Li, X., & Lou, Y. (2018). Talin2 regulates breast cancer cell migration and invasion by apoptosis. Oncology Letters, 16, 285-293. https://doi.org/10.3892/ol.2018.8641
MLA
Liang, Y., Chen, H., Ji, L., Du, J., Xie, X., Li, X., Lou, Y."Talin2 regulates breast cancer cell migration and invasion by apoptosis". Oncology Letters 16.1 (2018): 285-293.
Chicago
Liang, Y., Chen, H., Ji, L., Du, J., Xie, X., Li, X., Lou, Y."Talin2 regulates breast cancer cell migration and invasion by apoptosis". Oncology Letters 16, no. 1 (2018): 285-293. https://doi.org/10.3892/ol.2018.8641
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Chen H, Ji L, Du J, Xie X, Li X and Lou Y: Talin2 regulates breast cancer cell migration and invasion by apoptosis. Oncol Lett 16: 285-293, 2018.
APA
Liang, Y., Chen, H., Ji, L., Du, J., Xie, X., Li, X., & Lou, Y. (2018). Talin2 regulates breast cancer cell migration and invasion by apoptosis. Oncology Letters, 16, 285-293. https://doi.org/10.3892/ol.2018.8641
MLA
Liang, Y., Chen, H., Ji, L., Du, J., Xie, X., Li, X., Lou, Y."Talin2 regulates breast cancer cell migration and invasion by apoptosis". Oncology Letters 16.1 (2018): 285-293.
Chicago
Liang, Y., Chen, H., Ji, L., Du, J., Xie, X., Li, X., Lou, Y."Talin2 regulates breast cancer cell migration and invasion by apoptosis". Oncology Letters 16, no. 1 (2018): 285-293. https://doi.org/10.3892/ol.2018.8641
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