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Review

Role of interleukin‑32 in cancer biology (Review)

  • Authors:
    • Haimeng Yan
    • Donghua He
    • Xi Huang
    • Enfan Zhang
    • Qingxiao Chen
    • Ruyi Xu
    • Xinling Liu
    • Fuming Zi
    • Zhen Cai
  • View Affiliations / Copyright

    Affiliations: Bone Marrow Transplantation Centre, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China, Department of Haematology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330001, P.R. China
  • Pages: 41-47
    |
    Published online on: May 7, 2018
       https://doi.org/10.3892/ol.2018.8649
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Abstract

Interleukin‑32 (IL‑32), a novel proinflammatory cytokine, is highly expressed in various cancer tissues and in established cancer cell lines. IL‑32 has been revealed to serve a crucial role in human cancer development, including tumour initiation, proliferation and maintenance. The expression of IL‑32 is regulated by numerous factors, including genetic variations, hypoxia and acidosis in the tumour microenvironment. Understanding the underlying mechanisms of IL‑32 expression and its function are critical for the discovery of novel therapeutic strategies that target IL‑32. This is a review of the current literature on the regulation and function of IL‑32 in cancer progression, focusing on the molecular pathways linking IL‑32 and tumour development.
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1 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Colotta F, Allavena P, Sica A, Garlanda C and Mantovani A: Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability. Carcinogenesis. 30:1073–1081. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Hanahan D and Weinberg R: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wang L, Liu Z, Balivada S, Shrestha T, Bossmann S, Pyle M, Pappan L, Shi J and Troyer D: Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells. Stem Cell Res Ther. 3:52012. View Article : Google Scholar : PubMed/NCBI

5 

Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C and Lin J: STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Res. 71:7226–7237. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh AP, Carter JE, Scammell JG, Fodstad Ø and Singh S: Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis. Br J Cancer. 112:1772–1781. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Tao H, Lu L, Xia Y, Dai F, Wang Y, Bao Y, Lundy SK, Ito F, Pan Q, Zhang X, et al: Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10. Eur J Immunol. 45:999–1009. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Yoshimoto T, Chiba Y, Furusawa J, Xu M, Tsunoda R, Higuchi K and Mizoguchi I: Potential clinical application of interleukin-27 as an antitumor agent. Cancer Sci. 106:1103–1110. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kang YH, Park MY, Yoon DY, Han SR, Lee CI, Ji NY, Myung PK, Lee HG, Kim JW, Yeom YI, et al: Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2. Cancer Lett. 318:226–233. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Nishida A, Andoh A, Inatomi O and Fujiyama Y: Interleukin-32 expression in the pancreas. J Biol Chem. 284:17868–17876. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Yousif NG, Al-Amran FG, Hadi N, Lee J and Adrienne J: Expression of IL-32 modulates NF-κB and p38 MAP kinase pathways in human esophageal cancer. Cytokine. 61:223–227. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zeng Q, Li S, Zhou Y, Ou W, Cai X, Zhang L, Huang W, Huang L and Wang Q: Interleukin-32 contributes to invasion and metastasis of primary lung adenocarcinoma via NF-kappaB induced matrix metalloproteinases 2 and 9 expression. Cytokine. 65:24–32. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Tsai CY, Wang CS, Tsai MM, Chi HC, Cheng WL, Tseng YH, Chen CY, Lin CD, Wu JI, Wang LH and Lin KH: Interleukin-32 increases human gastric cancer cell invasion associated with tumor progression and metastasis. Clin Cancer Res. 20:2276–2288. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Yun HM, Park KR, Kim EC, Han SB, Yoon DY and Hong JT: IL-32α suppresses colorectal cancer development via TNFR1-mediated death signaling. Oncotarget. 6:9061–9072. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Park JS, Choi SY, Lee JH, Lee M, Nam ES, Jeong AL, Lee S, Han S, Lee MS, Lim JS, et al: Interleukin-32β stimulates migration of MDA-MB-231 and MCF-7cells via the VEGF-STAT3 signaling pathway. Cell Oncol (Dordr). 36:493–503. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Suga H, Sugaya M, Miyagaki T, Kawaguchi M, Fujita H, Asano Y, Tada Y, Kadono T and Sato S: The role of IL-32 in cutaneous T-cell lymphoma. J Invest Dermatol. 134:1428–1435. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Dahl CA, Schall RP, He HL and Cairns JS: Identification of a novel gene expressed in activated natural killer cells and T cells. J Immunol. 148:597–603. 1992.PubMed/NCBI

18 

Kim SH, Han SY, Azam T, Yoon DY and Dinarello CA: Interleukin-32: A cytokine and inducer of TNFalpha. Immunity. 22:131–142. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Kang JW, Park YS, Lee DH, Kim MS, Bak Y, Ham SY, Park SH, Kim H, Ahn JH, Hong JT and Yoon DY: Interaction network mapping among IL-32 isoforms. Biochimie. 101:248–251. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S and Izuhara K: Involvement of IL-32 in activation-induced cell death in T cells. Int Immunol. 18:233–240. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Choi JD, Bae SY, Hong JW, Azam T, Dinarello CA, Her E, Choi WS, Kim BK, Lee CK, Yoon DY, et al: Identification of the most active interleukin-32 isoform. Immunology. 126:535–542. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Heinhuis B, Koenders MI, van de Loo FA, Netea MG, van den Berg WB and Joosten LA: Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis. Proc Natl Acad Sci USA. 108:4962–4967. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Heinhuis B, Plantinga TS, Semango G, Küsters B, Netea MG, Dinarello CA, Smit JWA, Netea-Maier RT and Joosten LAB: Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines. Carcinogenesis. 37:197–205. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Jung MY, Son MH, Kim SH, Cho D and Kim TS: IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production. J Immunol. 186:6848–6859. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Yun HM, Kim JA, Hwang CJ, Jin P, Baek MK, Lee JM, Hong JE, Lee SM, Han SB, Oh KW, et al: Neuroinflammatory and amyloidogenic activities of IL-32β in Alzheimer's disease. Mol Neurobiol. 52:341–352. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Hong JT, Son DJ, Lee CK, Yoon DY, Lee DH and Park MH: Interleukin 32, Inflammation and Cancer. Pharmacol Ther. 174:127–137. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Kang JW, Park YS, Lee DH, Kim JH, Kim MS, Bak Y, Hong J and Yoon DY: Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells. J Biol Chem. 287:35556–35564. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Park YS, Kang JW, Lee DH, Kim MS, Bak Y, Yang Y, Lee HG, Hong J and Yoon DY: Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification. Oncotarget. 5:8765–8777. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Bak Y, Kang JW, Kim MS, Park YS, Kwon T, Kim S, Hong J and Yoon DY: IL-32θ downregulates CCL5 expression through its interaction with PKCδ and STAT3. Cell Signal. 26:3007–3015. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kang JW, Park YS, Lee DH, Kim MS, Bak Y, Park SH, Ham SY, Yang Y, Hong JT and Yoon DY: Interleukin-32δ interacts with IL-32β and inhibits IL-32β-mediated IL-10 production. FEBS Lett. Oct 25–2013.(Epub ahead of print). View Article : Google Scholar

31 

Hasegawa H, Thomas HJ, Schooley K and Born TL: Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein. Cytokine. 53:74–83. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Novick D, Rubinstein M, Azam T, Rabinkov A, Dinarello CA and Kim SH: Proteinase 3 is an IL-32 binding protein. Proc Natl Acad Sci USA. 103:3316–3321. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Heinhuis B, Koenders MI, van den Berg WB, Netea MG, Dinarello CA and Joosten LA: Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1. J Biol Chem. 287:5733–5743. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Netea MG, Lewis EC, Azam T, Joosten LA, Jaekal J, Bae SY, Dinarello CA and Kim SH: Interleukin-32 induces the differentiation of monocytes into macrophage-like cells. Proc Natl Acad Sci USA. 105:3515–3520. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Ohmatsu H, Humme D, Gonzalez J, Gulati N, Möbs M, Sterry W and Krueger JG: IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression. OncoImmunology. 6:e11812372016. View Article : Google Scholar : PubMed/NCBI

36 

Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, Barrera P, van de Loo FA, Dinarello CA and van den Berg WB: IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci USA. 103:3298–3303. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Calabrese F, Baraldo S, Bazzan E, Lunardi F, Rea F, Maestrelli P, Turato G, Lokar-Oliani K, Papi A, Zuin R, et al: IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 178:894–901. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Choi J, Bae S, Hong J, Ryoo S, Jhun H, Hong K, Yoon D, Lee S, Her E, Choi W, et al: Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis. Proc Natl Acad Sci USA. 107:21082–21086. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA and Chan ED: IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol. 184:3830–3840. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Sorrentino C and Di Carlo E: Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype. Am J Respir Crit Care Med. 180:769–779. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Lee S, Kim JH, Kim H, Kang JW, Kim SH, Yang Y, Kim J, Park J, Park S, Hong J and Yoon DY: Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expressionof interleukin-32 controls the expression of the humanpapillomavirus oncogene. Immunology. 132:410–420. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA and Deeg HJ: Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc Natl Acad Sci USA. 105:2865–2870. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Wang S, Chen F and Tang L: IL-32 promotes breast cancer cell growth and invasiveness. Oncol Lett. 9:305–307. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Lin X, Yang L, Wang G, Zi F, Yan H, Guo X, Chen J, Chen Q, Huang X, Li Y, et al: Interleukin-32α promotes the proliferation of multiple myeloma cells by inducing production of IL-6 in bone marrow stromal cells. Oncotarget. 8:92841–92854. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Oh JH, Cho MC, Kim JH, Lee SY, Kim HJ, Park ES, Ban JO, Kang JW, Lee DH, Shim JH, et al: IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals. Oncogene. 30:3345–3359. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Yun HM, Oh JH, Shim JH, Ban JO, Park KR, Kim JH, Lee DH, Kang JW, Park YH, Yu D, et al: Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals. Cell Death Dis. 4:e6402013. View Article : Google Scholar : PubMed/NCBI

47 

Cheon S, Lee JH, Park S, Bang SI, Lee WJ, Yoon DY, Yoon SS, Kim T, Min H, Cho BJ, et al: Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells. J Biol Chem. 286:12049–12055. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Park ES, Yoo JM, Yoo HS, Yoon DY, Yun YP and Hong J: IL-32γ enhances TNF-α-induced cell death in colon cancer. Mol Carcinog. 53 Suppl 1:E23–E35. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Qu Y, Taylor JL, Bose A and Storkus WJ: Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32. Cancer Gene Ther. 18:663–673. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Alberti L, Bachelot T, Duc A, Biota C and Blay JY: A spliced isoform of interleukin 6 mRNA produced by renal cell carcinoma encodes for an interleukin 6 inhibitor. Cancer Res. 65:2–5. 2005.PubMed/NCBI

51 

Sahoo A, Jung YM, Kwon HK, Yi HJ, Lee S, Chang S, Park ZY, Hwang KC and Im SH: A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis. J Biol Chem. 283:28860–28872. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Guenin S, Mouallif M, Hubert P, Jacobs N, Krusy N, Duray A, Ennaji MM, Saussez S and Delvenne P: Interleukin-32 expression is associated with a poorer prognosis in head and neck squamous cell carcinoma. Mol Carcinog. 53:667–673. 2014.PubMed/NCBI

53 

Lee J, Kim KE, Cheon S, Song JH, Houh Y, Kim TS, Gil M, Lee KJ, Kim S, Kim D, et al: Interleukin-32α induces migration of human melanoma cells through downregulation of E-cadherin. Oncotarget. 7:65825–65836. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Zhou Y, Hu Z, Li N and Jiang R: Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression. Int J Mol Med. 35:1729–1733. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Bak Y, Kwon T, Bak IS, Hong J, Yu DY and Yoon DY: IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer. Oncotarget. 7:7307–7317. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, et al: IL-32 promotes angiogenesis. J Immunol. 192:589–602. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Mabilleau G and Sabokbar A: Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS One. 4:e41732009. View Article : Google Scholar : PubMed/NCBI

58 

Netea MG, Azam T, Ferwerda G, Girardin SE, Walsh M, Park JS, Abraham E, Kim JM, Yoon DY, Dinarello CA and Kim SH: IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci USA. 102:16309–16314. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Joosten LA, Heinhuis B, Netea MG and Dinarello CA: Novel insights into the biology of interleukin-32. Cell Mol Life Sci. 70:3883–3892. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Plantinga TS, Costantini I, Heinhuis B, Huijbers A, Semango G, Kusters B, Netea MG, Hermus AR, Smit JW, Dinarello CA, et al: A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma. Carcinogenesis. 34:1529–1535. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Chang CJ, Chien Y, Lu KH, Chang SC, Chou YC, Huang CS, Chang CH, Chen KH, Chang YL, Tseng LM, et al: Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells. Biochem Biophys Res Commun. 415:245–251. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Majid S, Dar AA, Saini S, Yamamura S, Hirata H, Tanaka Y, Deng G and Dahiya R: MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. Cancer. 116:5637–5649. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Zaman MS, Thamminana S, Shahryari V, Chiyomaru T, Deng G, Saini S, Majid S, Fukuhara S, Chang I, Arora S, et al: Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer. PLoS One. 7:e502032012. View Article : Google Scholar : PubMed/NCBI

64 

Park JS, Lee S, Jeong AL, Han S, Ka HI, Lim JS, Lee MS, Yoon DY, Lee JH and Yang Y: Hypoxia-induced IL-32β increases glycolysis in breast cancer cells. Cancer Lett. 356:800–808. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Zahoor M, Westhrin M, Aass KR, Moen SH, Misund K, Psonka-Antonczyk KM, Giliberto M, Buene G, Sundan A, Waage A, et al: Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss. Blood Adv. 1:2656–2666. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Fukamachi T, Ikeda S, Wang X, Saito H, Tagawa M and Kobayashi H: Gene expressions for signal transduction under acidic conditions. Genes (Basel). 4:65–85. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan H, He D, Huang X, Zhang E, Chen Q, Xu R, Liu X, Zi F and Cai Z: Role of interleukin‑32 in cancer biology (Review). Oncol Lett 16: 41-47, 2018.
APA
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R. ... Cai, Z. (2018). Role of interleukin‑32 in cancer biology (Review). Oncology Letters, 16, 41-47. https://doi.org/10.3892/ol.2018.8649
MLA
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R., Liu, X., Zi, F., Cai, Z."Role of interleukin‑32 in cancer biology (Review)". Oncology Letters 16.1 (2018): 41-47.
Chicago
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R., Liu, X., Zi, F., Cai, Z."Role of interleukin‑32 in cancer biology (Review)". Oncology Letters 16, no. 1 (2018): 41-47. https://doi.org/10.3892/ol.2018.8649
Copy and paste a formatted citation
x
Spandidos Publications style
Yan H, He D, Huang X, Zhang E, Chen Q, Xu R, Liu X, Zi F and Cai Z: Role of interleukin‑32 in cancer biology (Review). Oncol Lett 16: 41-47, 2018.
APA
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R. ... Cai, Z. (2018). Role of interleukin‑32 in cancer biology (Review). Oncology Letters, 16, 41-47. https://doi.org/10.3892/ol.2018.8649
MLA
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R., Liu, X., Zi, F., Cai, Z."Role of interleukin‑32 in cancer biology (Review)". Oncology Letters 16.1 (2018): 41-47.
Chicago
Yan, H., He, D., Huang, X., Zhang, E., Chen, Q., Xu, R., Liu, X., Zi, F., Cai, Z."Role of interleukin‑32 in cancer biology (Review)". Oncology Letters 16, no. 1 (2018): 41-47. https://doi.org/10.3892/ol.2018.8649
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