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Review

The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)

  • Authors:
    • Ha Thi Nguyen
    • Hong‑Quan Duong
  • View Affiliations / Copyright

    Affiliations: Center for Molecular Biology, Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam, Department of Cancer Research, Vinmec Research Institute of Stem Cell and Gene Technology, Hanoi 100000, Vietnam
  • Pages: 9-18
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    Published online on: May 9, 2018
       https://doi.org/10.3892/ol.2018.8679
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Abstract

Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma is caused by three major pathways: Microsatellite instability, chromosomal instability and CpG island methylator phenotype. A growing body of scientific evidences suggests that CRC is a heterogeneous disease, and genetic characteristics of the tumors determine their prognostic outcome and response to targeted therapies. Early diagnosis and effective targeted therapies based on a current knowledge of the molecular characteristics of CRC are essential to the successful treatment of CRC. Therefore, the present review summarized the current understanding of the molecular characteristics of CRC, and discussed its implications for diagnosis and targeted therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Nguyen HT and Duong HQ: The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review). Oncol Lett 16: 9-18, 2018.
APA
Nguyen, H.T., & Duong, H. (2018). The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review). Oncology Letters, 16, 9-18. https://doi.org/10.3892/ol.2018.8679
MLA
Nguyen, H. T., Duong, H."The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)". Oncology Letters 16.1 (2018): 9-18.
Chicago
Nguyen, H. T., Duong, H."The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)". Oncology Letters 16, no. 1 (2018): 9-18. https://doi.org/10.3892/ol.2018.8679
Copy and paste a formatted citation
x
Spandidos Publications style
Nguyen HT and Duong HQ: The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review). Oncol Lett 16: 9-18, 2018.
APA
Nguyen, H.T., & Duong, H. (2018). The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review). Oncology Letters, 16, 9-18. https://doi.org/10.3892/ol.2018.8679
MLA
Nguyen, H. T., Duong, H."The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)". Oncology Letters 16.1 (2018): 9-18.
Chicago
Nguyen, H. T., Duong, H."The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)". Oncology Letters 16, no. 1 (2018): 9-18. https://doi.org/10.3892/ol.2018.8679
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