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Review

Antitumor mechanisms of bifidobacteria (Review)

  • Authors:
    • Hongyun Wei
    • Linlin Chen
    • Guanghui Lian
    • Junwen Yang
    • Fujun Li
    • Yiyou Zou
    • Fanggen Lu
    • Yani Yin
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 3-8
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    Published online on: May 10, 2018
       https://doi.org/10.3892/ol.2018.8692
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Abstract

Cancer remains one of the most common causes of mortality globally. Chemotherapy, one of the major treatment strategies for cancer, primarily functions by targeting the cancer cells and affecting them physiologically, but also affects normal cells, which is a major concern at present. Therefore, adverse effects of chemotherapy drugs, including myelosuppression and liver and kidney damage, are of concern. Now, microbial products have attracted attention in cancer treatment research. Notably, carcinogenesis is considered to be associated with microbial dysbiosis, particularly the positive antitumor effects of bifidobacteria. Although there remains a substantial amount to be understood about the regulation of bifidobacteria, bifidobacteria remain an attractive and novel source of cancer therapeutics. The present review focuses on introducing the latest information on the antitumor effects of bifidobacteria and to propose future strategies for using bifidobacteria in the development of cancer therapeutics.
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1 

Bottacini F, van Sinderen D and Ventura M: Omics of bifidobacteria: Research and insights into their health-promoting activities. Biochem J. 474:4137–4152. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Biarc J, Nguyen IS, Pini A, Gossé F, Richert S, Thiersé D, Van Dorsselaer A, Leize-Wagner E, Raul F, Klein JP and Schöller-Guinard M: Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S. bovis). Carcinogenesis. 25:1477–1484. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Wei C, Xun AY, Wei XX, Yao J, Wang JY, Shi RY, Yang GH, Li YX, Xu ZL, Lai MG, et al: Bifidobacteria expressing tumstatin protein for antitumor therapy in tumor-bearing mice. Technol Cancer Res Treat. 15:498–508. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Liboredo JC, Anastácio LR, Pelúzio Mdo C, Valente FX, Penido LC, Nicoli JR and Correia MI: Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon. Acta Cir Bras. 28:367–372. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Lai LR, Hsieh SC, Huang HY and Chou CC: Effect of lactic fermentation on the total phenolic, saponin and phytic acid contents as well as anti-colon cancer cell proliferation activity of soymilk. J Biosci Bioeng. 115:552–556. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kim KA, Jung IH, Park SH, Ahn YT, Huh CS and Kim DH: Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K. PloS One. 8:e624092013. View Article : Google Scholar : PubMed/NCBI

7 

Schroeder BO, Birchenough GMH, Stahlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F: Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host Microbe. 23:27–40.e7. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Thum C, Roy NC, McNabb WC, Otter DE and Cookson AL: In vitro fermentation of caprine milk oligosaccharides by bifidobacteria isolated from breast-fed infants. Gut Microbes. 6:352–363. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Asakuma S, Hatakeyama E, Urashima T, Yoshida E, Katayama T, Yamamoto K, Kumagai H, Ashida H, Hirose J and Kitaoka M: Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria. J Biol Chem. 286:34583–34592. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ku S, You HJ, Park MS and Ji GE: Effects of ascorbic acid on α-l-arabinofuranosidase and α-l-arabinopyranosidase activities from RD47 and its application to whole cell bioconversion of ginsenoside. J Korean Soc Appl Biol Chem. 58:857–865. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Egan M, Motherway MO, Kilcoyne M, Kane M, Joshi L, Ventura M and van Sinderen D: Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium. BMC Microbiol. 14:2822014. View Article : Google Scholar : PubMed/NCBI

12 

Bayoumi MA and Griffiths MW: In vitro inhibition of expression of virulence genes responsible for colonization and systemic spread of enteric pathogens using Bifidobacterium bifidum secreted molecules. Int J Food Microbiol. 156:255–263. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kim JE, Kim JY, Lee KW and Lee HJ: Cancer chemopreventive effects of lactic acid bacteria. J Microbiol Biotechnol. 17:1227–1235. 2007.PubMed/NCBI

14 

Oikarinen S, Heinonen S, Karppinen S, Mättö J, Adlercreutz H, Poutanen K and Mutanen M: Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions. Br J Nutr. 90:119–125. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Bindels LB, Neyrinck AM, Salazar N, Taminiau B, Druart C, Muccioli GG, Francois E, Blecker C, Richel A, Daube G, et al: Non digestible oligosaccharides modulate the gut microbiota to control the development of leukemia and associated cachexia in mice. PloS One. 10:e01310092015. View Article : Google Scholar : PubMed/NCBI

16 

Silva Oliveira E, de Carvalho Cruz T, Parshikov IA, dos Santos Alves R, Emery Silva F and Furtado Jacometti Cardoso NA: Cytotoxicity of lapachol metabolites produced by probiotics. Lett Appl Microbiol. 59:108–114. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Hidaka A, Hamaji Y, Sasaki T, Taniguchi S and Fujimori M: Exogenous cytosine deaminase gene expression in Bifidobacterium breve I-53-8w for tumor-targeting enzyme/ prodrug therapy. Biosci Biotechnol Biochem. 71:2921–2926. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Nakamura T, Sasaki T, Fujimori M, Yazawa K, Kano Y, Amano J and Taniguchi S: Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors. Biosci Biotechnol Biochem. 66:2362–2366. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Bae EA, Park SY and Kim DH: Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 23:1481–1485. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Apás AL, Dupraz J, Ross R, González SN and Arena ME: Probiotic administration effect on fecal mutagenicity and microflora in the goat's gut. J Biosci Bioeng. 110:537–540. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Lo PR, Yu RC, Chou CC and Huang EC: Determinations of the antimutagenic activities of several probiotic bifidobacteria under acidic and bile conditions against benzo[a]pyrene by a modified Ames test. Int J Food Microbiol. 93:249–257. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Osswald A, Westermann C, Sun Z and Riedel CU: A phytase-based reporter system for identification of functional secretion signals in bifidobacteria. PloS One. 10:e01288022015. View Article : Google Scholar : PubMed/NCBI

23 

Jiang L, Xiao X, Ren J, Tang Y, Weng H, Yang Q, Wu M and Tang W: Proteomic analysis of bladder cancer indicates Prx-I as a key molecule in BI-TK/GCV treatment system. PloS One. 9:e987642014. View Article : Google Scholar : PubMed/NCBI

24 

Xiao X, Jin R, Li J, Bei Y and Wei T: The antitumor effect of suicide gene therapy using Bifidobacterium infantis-mediated herpes simplex virus thymidine kinase/ganciclovir in a nude mice model of renal cell carcinoma. Urology. 84(982): e15–e20. 2014.PubMed/NCBI

25 

Reddy BS: Possible mechanisms by which pro- and prebiotics influence colon carcinogenesis and tumor growth. J Nutr. 129 7 Suppl:S1478–S1482. 1999. View Article : Google Scholar

26 

Rodrigues MA, Silva LA, Salvadori DM, De Camargo JL and Montenegro MR: Aberrant crypt foci and colon cancer: Comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats. Braz J Med Biol Res. 35:351–355. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Kulkarni N and Reddy BS: Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase. Proc Soc Exp Biol Med. 207:278–283. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, Clune Y, Collins KJ, Paglierani M and Caderni G: Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis. 23:1953–1960. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Yin Y, Wang RR, Wang Y, Wang JJ and Xu GX: Preparation of selenium-enriched Bifidobacterium longum and its effect on tumor growth and immune function of tumor-bearing mice. Asian Pac J Cancer Prev. 15:3681–3686. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Sekine K, Toida T, Saito M, Kuboyama M, Kawashima T and Hashimoto Y: A new morphologically characterized cell wall preparation (whole peptidoglycan) from Bifidobacterium infantis with a higher efficacy on the regression of an established tumor in mice. Cancer Res. 45:1300–1307. 1985.PubMed/NCBI

31 

Rowland IR, Rumney CJ, Coutts JT and Lievense LC: Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis. 19:281–285. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Simone M, Gozzoli C, Quartieri A, Mazzola G, Di Gioia D, Amaretti A, Raimondi S and Rossi M: The probiotic Bifidobacterium breve B632 inhibited the growth of Enterobacteriaceae within colicky infant microbiota cultures. Biomed Res Int. 2014:3010532014. View Article : Google Scholar : PubMed/NCBI

33 

Mogna L, Del Piano M and Mogna G: Capability of the two microorganisms Bifidobacterium breve B632 and Bifidobacterium breve BR03 to colonize the intestinal microbiota of children. J Clin Gastroenterol. 48 Suppl 1:S37–S39. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Fooks LJ and Gibson GR: Probiotics as modulators of the gut flora. Br J Nutr. 88 Suppl 1:S39–S49. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Dhanani AS and Bagchi T: Lactobacillus plantarum CS24.2 prevents E. coli adhesion to HT-29 cells and also down-regulates enteropathogen induced TNF-α and IL-8 expression. Microbiol Immunol. 57:309–315. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Tareb R, Bernardeau M, Gueguen M and Vernoux JP: In vitro characterization of aggregation and adhesion properties of viable and heat-killed forms of two probiotic Lactobacillus strains and interaction with foodborne zoonotic bacteria, especially Campylobacter jejuni. J Med Microbiol. 62:637–649. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Kolenbrander PE, Palmer RJ Jr, Periasamy S and Jakubovics NS: Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev Microbiol. 8:471–480. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Cadieux PA, Burton J, Devillard E and Reid G: Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli. J Physiol Pharmacol. 60 Suppl 6:S13–S18. 2009.

39 

McMillan A, Dell M, Zellar MP, Cribby S, Martz S, Hong E, Fu J, Abbas A, Dang T, Miller W and Reid G: Disruption of urogenital biofilms by lactobacilli. Colloids Surf B Biointerfaces. 86:58–64. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Velraeds MM, van de Belt-Gritter B, van der Mei HC, Reid G and Busscher HJ: Interference in initial adhesion of uropathogenic bacteria and yeasts to silicone rubber by a Lactobacillus acidophilus biosurfactant. J Med Microbiol. 47:1081–1085. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Apás AL, González SN and Arena ME: Potential of goat probiotic to bind mutagens. Anaerobe. 28:8–12. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Asaduzzaman SM and Sonomoto K: Lantibiotics: Diverse activities and unique modes of action. J Biosci Bioeng. 107:475–487. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Xu HY, Tian WH, Wan CX, Jia LJ, Wang LY, Yuan J, Liu CM, Zeng M and Wei H: Antagonistic potential against pathogenic microorganisms and hydrogen peroxide production of indigenous lactobacilli isolated from vagina of Chinese pregnant women. Biomed Environ Sci. 21:365–371. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Martín R and Suárez JE: Biosynthesis and degradation of H2O2 by vaginal lactobacilli. Appl Environ Microbiol. 76:400–405. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Lankaputhra WE and Shah NP: Antimutagenic properties of probiotic bacteria and of organic acids. Mutat Res. 397:169–182. 1998. View Article : Google Scholar : PubMed/NCBI

46 

Sreekumar O and Hosono A: The antimutagenic properties of a polysaccharide produced by Bifidobacterium longum and its cultured milk against some heterocyclic amines. Can J Microbiol. 44:1029–1036. 1998. View Article : Google Scholar : PubMed/NCBI

47 

Reddy BS: Prevention of colon cancer by pre- and probiotics: Evidence from laboratory studies. Br J Nutr. 80:S219–S223. 1998.PubMed/NCBI

48 

Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N and Reddy BS: Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis. 18:833–841. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Verma A and Shukla G: Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats. Nutr Cancer. 65:84–91. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Lee do K, Jang S, Baek EH, Kim MJ, Lee KS, Shin HS, Chung MJ, Kim JE, Lee KO and Ha NJ: Lactic acid bacteria affect serum cholesterol levels, harmful fecal enzyme activity, and fecal water content. Lipids Health Dis. 8:212009. View Article : Google Scholar : PubMed/NCBI

51 

Suerbaum S and Michetti P: Helicobacter pylori infection. N Engl J Med. 347:1175–1186. 2002. View Article : Google Scholar : PubMed/NCBI

52 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Swidsinski A, Khilkin M, Kerjaschki D, Schreiber S, Ortner M, Weber J and Lochs H: Association between intraepithelial Escherichia coli and colorectal cancer. Gastroenterology. 115:281–286. 1998. View Article : Google Scholar : PubMed/NCBI

54 

Abdulamir AS, Hafidh RR, Mahdi LK, Al-jeboori T and Abubaker F: Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma. BMC Cancer. 9:4032009. View Article : Google Scholar : PubMed/NCBI

55 

Gupta A, Madani R and Mukhtar H: Streptococcus bovis endocarditis, a silent sign for colonic tumour. Colorectal Dis. 12:164–171. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Bernet MF, Brassart D, Neeser JR and Servin AL: Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactions. Appl Environ Microbiol. 59:4121–4128. 1993.PubMed/NCBI

57 

Kavanaugh DW, O'Callaghan J, Buttó LF, Slattery H, Lane J, Clyne M, Kane M, Joshi L and Hickey RM: Exposure of Bifidobacterium longum subsp. infantis to milk oligosaccharides increases adhesion to epithelial cells and induces a substantial transcriptional response. PloS One. 8:e672242013. View Article : Google Scholar : PubMed/NCBI

58 

Wickramasinghe S, Pacheco AR, Lemay DG and Mills DA: Bifidobacteria grown on human milk oligosaccharides downregulate the expression of inflammation-related genes in Caco-2 cells. BMC Microbiol. 15:1722015. View Article : Google Scholar : PubMed/NCBI

59 

Chichlowski M, De Lartigue G, German JB, Raybould HE and Mills DA: Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function. J Pediatr Gastroenterol Nutr. 55:321–327. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Gu QY, Zhang J and Feng YC: Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome. Artif Cells Nanomed Biotechnol. 44:1933–1937. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Wu BB, Yang Y, Xu X and Wang WP: Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants. World J Pediatr. 12:177–182. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, et al: A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 15:1016–1022. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Mortaz E, Adcock IM, Folkerts G, Barnes PJ, Vos Paul A and Garssen J: Probiotics in the management of lung diseases. Mediators Inflamm. 2013:7510682013. View Article : Google Scholar : PubMed/NCBI

64 

Helwig U, Lammers KM, Rizzello F, Brigidi P, Rohleder V, Caramelli E, Gionchetti P, Schrezenmeir J, Foelsch UR, Schreiber S and Campieri M: Lactobacilli, bifidobacteria and E. coli nissle induce pro- and anti-inflammatory cytokines in peripheral blood mononuclear cells. World J Gastroenterol. 12:5978–5986. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Korn T, Bettelli E, Oukka M and Kuchroo VK: IL-17 and Th17 cells. Ann Rev Immunol. 27:485–517. 2009. View Article : Google Scholar

66 

Lin W, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, Martin MG and Chatila TA: Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol. 116:1106–1115. 2005. View Article : Google Scholar : PubMed/NCBI

67 

Feleszko W, Jaworska J, Rha RD, Steinhausen S, Avagyan A, Jaudszus A, Ahrens B, Groneberg DA, Wahn U and Hamelmann E: Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy. 37:498–505. 2007. View Article : Google Scholar : PubMed/NCBI

68 

Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, et al: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 350:1084–1089. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Yin Y, Kou L, Wang JJ and Xu GX: Therapeutic efficacy of Bifidobacterium longum-mediated human interleukin-2 with endostatin or TRAIL in transplanted tumors in mice. Exp Ther Med. 3:481–486. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Bordonaro M, Lazarova DL and Sartorelli AC: Butyrate and Wnt signaling: A possible solution to the puzzle of dietary fiber and colon cancer risk? Cell Cycle. 7:1178–1183. 2008. View Article : Google Scholar : PubMed/NCBI

71 

Mäkivuokko H, Tiihonen K, Tynkkynen S, Paulin L and Rautonen N: The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr. 103:227–234. 2010. View Article : Google Scholar : PubMed/NCBI

72 

Bergmann KR, Liu SX, Tian R, Kushnir A, Turner JR, Li HL, Chou PM, Weber CR and De Plaen IG: Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol. 182:1595–1606. 2013. View Article : Google Scholar : PubMed/NCBI

73 

Ewaschuk JB, Diaz H, Meddings L, Diederichs B, Dmytrash A, Backer J, Looijer-van Langen M and Madsen KL: Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J Physiol Gastrointest Liver Physiol. 295:G1025–G1034. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Becker S, Oelschlaeger TA, Wullaert A, Vlantis K, Pasparakis M, Wehkamp J, Stange EF and Gersemann M: Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PloS One. 8:e556202013. View Article : Google Scholar : PubMed/NCBI

75 

de Vrese M and Schrezenmeir J: Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol. 111:1–66. 2008.PubMed/NCBI

76 

Ricciuti B, Foglietta J, Bianconi V, Sahebkar A and Pirro M: Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy. Semin Cancer Biol: S1044-579X(17)30043-3. 2017. View Article : Google Scholar

77 

Zhu H, Li Z, Mao S, Ma B, Zhou S, Deng L, Liu T, Cui D, Zhao Y, He J, et al: Antitumor effect of sFlt-1 gene therapy system mediated by Bifidobacterium infantis on Lewis lung cancer in mice. Cancer Gene Ther. 18:884–896. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Sudhakar A and Boosani CS: Inhibition of tumor angiogenesis by tumstatin: Insights into signaling mechanisms and implications in cancer regression. Pharm Res. 25:2731–2739. 2008. View Article : Google Scholar : PubMed/NCBI

79 

Wei C, Xun AY, Wei XX, Yao J, Wang JY, Shi RY, Yang GH, Li YX, Xu ZL, Lai MG, et al: Bifidobacteria expressing tumstatin protein for antitumor therapy in tumor-bearing mice. Technol Cancer Res Treat. 15:498–508. 2016. View Article : Google Scholar : PubMed/NCBI

80 

Yi C, Huang Y, Guo ZY and Wang SR: Antitumor effect of cytosine deaminase/5-fluorocytosine suicide gene therapy system mediated by Bifidobacterium infantis on melanoma. Acta Pharmacol Sin. 26:629–634. 2005. View Article : Google Scholar : PubMed/NCBI

81 

Sasaki T, Fujimori M, Hamaji Y, Hama Y, Ito K, Amano J and Taniguchi S: Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats. Cancer Sci. 97:649–657. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei H, Chen L, Lian G, Yang J, Li F, Zou Y, Lu F and Yin Y: Antitumor mechanisms of bifidobacteria (Review). Oncol Lett 16: 3-8, 2018.
APA
Wei, H., Chen, L., Lian, G., Yang, J., Li, F., Zou, Y. ... Yin, Y. (2018). Antitumor mechanisms of bifidobacteria (Review). Oncology Letters, 16, 3-8. https://doi.org/10.3892/ol.2018.8692
MLA
Wei, H., Chen, L., Lian, G., Yang, J., Li, F., Zou, Y., Lu, F., Yin, Y."Antitumor mechanisms of bifidobacteria (Review)". Oncology Letters 16.1 (2018): 3-8.
Chicago
Wei, H., Chen, L., Lian, G., Yang, J., Li, F., Zou, Y., Lu, F., Yin, Y."Antitumor mechanisms of bifidobacteria (Review)". Oncology Letters 16, no. 1 (2018): 3-8. https://doi.org/10.3892/ol.2018.8692
Copy and paste a formatted citation
x
Spandidos Publications style
Wei H, Chen L, Lian G, Yang J, Li F, Zou Y, Lu F and Yin Y: Antitumor mechanisms of bifidobacteria (Review). Oncol Lett 16: 3-8, 2018.
APA
Wei, H., Chen, L., Lian, G., Yang, J., Li, F., Zou, Y. ... Yin, Y. (2018). Antitumor mechanisms of bifidobacteria (Review). Oncology Letters, 16, 3-8. https://doi.org/10.3892/ol.2018.8692
MLA
Wei, H., Chen, L., Lian, G., Yang, J., Li, F., Zou, Y., Lu, F., Yin, Y."Antitumor mechanisms of bifidobacteria (Review)". Oncology Letters 16.1 (2018): 3-8.
Chicago
Wei, H., Chen, L., Lian, G., Yang, J., Li, F., Zou, Y., Lu, F., Yin, Y."Antitumor mechanisms of bifidobacteria (Review)". Oncology Letters 16, no. 1 (2018): 3-8. https://doi.org/10.3892/ol.2018.8692
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