Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma

  • Authors:
    • Weipeng Zhao
    • Xiaoying Zhang
    • Li Zang
    • Pan Zhao
    • Yafang Chen
    • Xiaofang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China, Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China
  • Pages: 1101-1106
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/ol.2018.8711
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angiogenic activity in solid tumors has been demonstrated to promote metastasis through the activation of certain proteins involved in the epithelial‑mesenchymal transition‑associated process. The molecular mechanism underlying multiple myeloma‑induced angiogenesis involves angiogenic cytokines by plasma cells as well as their induction within the microenvironment. Integrin‑linked kinase (ILK) is a highly evolutionarily conserved intracellular protein that was originally identified as an integrin‑interacting protein, and extensive genetic and biochemical studies have identified ILK expression to be vital during tumor‑driven angiogenesis. In the present study, it was identified that angiogenic factors were upregulated in mesenchymal stem cells (MSCs) that were co‑cultured with multiple myeloma cell lines. It was also revealed that upregulated ILK expression significantly promoted the capillary‑formation ability of MSCs. The concentrations of angiogenic factors were significantly decreased compared with non‑targeting siRNA‑transfected and control MSCs. MSCs may participate in inducing the angiogenic response in multiple myeloma depending on ILK expression.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Rollig C, Knop S and Bornhäuser M: Multiple myeloma. Lancet. 385:2197–2208. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Quarona V, Ferri V, Chillemi A, Bolzoni M, Mancini C, Zaccarello G, Roato I, Morandi F, Marimpietri D, Faccani G, et al: Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche. Ann N Y Acad Sci. 1335:10–22. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Kikuchi J and Furukawa Y: The mechanisms of drug resistance via the interaction of myeloma cells with stromal cells. Nihon Rinsho. 73:57–61. 2015.(In Japanese). PubMed/NCBI

4 

Toscani D, Bolzoni M, Accardi F, Aversa F and Giuliani N: The osteoblastic niche in the context of multiple myeloma. Ann N Y Acad Sci. 1335:45–62. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Hannigan GE, McDonald PC, Walsh MP and Dedhar S: Integrin-linked kinase: Not so ‘pseudo’ after all. Oncogene. 30:4375–4385. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cabodi S, del Pilar Camacho-Leal M, Di Stefano P and Defilippi P: Integrin signalling adaptors: Not only figurants in the cancer story. Nat Rev Cancer. 10:858–870. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Steinbrunn T, Siegmund D, Andrulis M, Grella E, Kortüm M, Einsele H, Wajant H, Bargou RC and Stühmer T: Integrin-linked kinase is dispensable for multiple myeloma cell survival. Leuk Res. 36:1165–1171. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Shibue T, Brooks MW and Weinberg RA: An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell. 24:481–498. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Song SW, Chang W, Song BW, Song H, Lim S, Kim HJ, Cha MJ, Choi E, Im SH, Chang BC, et al: Integrin-linked kinase is required in hypoxic mesenchymal stem cells for strengthening cell adhesion to ischemic myocardium. Stem Cells. 27:1358–1365. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Goessler UR, Bugert P, Bieback K, Stern-Straeter J, Bran G, Hörmann K and Riedel F: Integrin expression in stem cells from bone marrow and adipose tissue during chondrogenic differentiation. Int J Mol Med. 21:271–279. 2008.PubMed/NCBI

11 

Wang X, Zhang Z and Yao C: Angiogenic activity of mesenchymal stem cells in multiple myeloma. Cancer Invest. 29:37–41. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Portalska Janeczek K, Leferink A, Groen N, Fernandes H, Moroni L, van Blitterswijk C and de Boer J: Endothelial differentiation of mesenchymal stromal cells. PLoS One. 7:e468422012. View Article : Google Scholar : PubMed/NCBI

13 

Wang X, Zhang Z and Yao C: Bortezomib inhibits the angiogenesis mediated by mesenchymal stem cells. Cancer Invest. 30:657–662. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Ribatti D, Basile A, Ruggieri S and Vacca A: Bone marrow vascular niche and the control of angiogenesis in multiple myeloma. Front Biosci (Landmark Ed). 19:304–311. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Vacca A, Ria R, Reale A and Ribatti D: Angiogenesis in multiple myeloma. Chem Immunol Allergy. 99:180–196. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Mao Q, Lin CX, Liang XL, Gao JS and Xu B: Mesenchymal stem cells overexpressing integrin-linked kinase attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. Mol Med Rep. 7:1617–1623. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Malinin NL, Pluskota E and Byzova TV: Integrin signaling in vascular function. Curr Opin Hematol. 19:206–211. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA and Lander ES: Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 138:645–659. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Shibue T, Brooks MW, Inan MF, Reinhardt F and Weinberg RA: The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov. 2:706–721. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Elzamly S, Agina HA, Elbalshy AE, Abuhashim M, Saad E and Elmageed Abd ZY: Integration of VEGF and α-SMA expression improves the prediction accuracy of fibrosis in chronic hepatitis C liver biopsy. Appl Immunohistochem Mol Morphol. 25:261–270. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Tonino P and Abreu C: Microvessel density is associated with vegf and alpha-sma expression in different regions of human gastrointestinal carcinomas. Cancers (Basel). 3:3405–3418. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao W, Zhang X, Zang L, Zhao P, Chen Y and Wang X: ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma. Oncol Lett 16: 1101-1106, 2018.
APA
Zhao, W., Zhang, X., Zang, L., Zhao, P., Chen, Y., & Wang, X. (2018). ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma. Oncology Letters, 16, 1101-1106. https://doi.org/10.3892/ol.2018.8711
MLA
Zhao, W., Zhang, X., Zang, L., Zhao, P., Chen, Y., Wang, X."ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma". Oncology Letters 16.1 (2018): 1101-1106.
Chicago
Zhao, W., Zhang, X., Zang, L., Zhao, P., Chen, Y., Wang, X."ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma". Oncology Letters 16, no. 1 (2018): 1101-1106. https://doi.org/10.3892/ol.2018.8711
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao W, Zhang X, Zang L, Zhao P, Chen Y and Wang X: ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma. Oncol Lett 16: 1101-1106, 2018.
APA
Zhao, W., Zhang, X., Zang, L., Zhao, P., Chen, Y., & Wang, X. (2018). ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma. Oncology Letters, 16, 1101-1106. https://doi.org/10.3892/ol.2018.8711
MLA
Zhao, W., Zhang, X., Zang, L., Zhao, P., Chen, Y., Wang, X."ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma". Oncology Letters 16.1 (2018): 1101-1106.
Chicago
Zhao, W., Zhang, X., Zang, L., Zhao, P., Chen, Y., Wang, X."ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma". Oncology Letters 16, no. 1 (2018): 1101-1106. https://doi.org/10.3892/ol.2018.8711
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team